Twentieth Century Mouse Genetics

Dr. Robert P. Erickson is the Holsclaw Family Professor Emeritus of Human Genetics and Inherited Diseases, Department of Pediatrics, University of Arizona College of Medicine. He has had a 50 year career of research in human and murine genetics, especially molecular, and patient care. He is author of over 400 scientific and medical papers and has co-authored or co-edited 5 books. He has received Guggenheim and Eleanor Roosevelt Fellowships, was made an honorary visiting fellow of Hughes Hall, University of Cambridge, and a visiting research professor at Universita Roma de la Sapienza. His public service includes being an appointee by then Governor Napolitano to the Arizona Biomedical Research Committee, membership of the Recombinant DNA Advisory Committee (RAC) of the National Institutes of Health and membership of the Scientific Board of Advisors of the International Institute of Molecular and Cellular Biology in Warsaw. He is listed in Who’s Who of America.

"This book will have strong appeal to a limited audience. Those interested in the history and development of mouse genetics, and of mouse genetics in the wider context of the history of genetics, will find this book an interesting read. Indeed, it stands out from other books covering similar topics by the personal experience of the author in the field. " --© Doody’s Review Service, 2021, Mark F. Sanders, PhD, reviewer, expert opinion

• 1. The origins of mouse genetics and the discovery of the T-locus2. The evolutionary modern synthesis, t-haplotypes in the wild, and reproductive isolation3. Linkage studies, cytogenetics, and the discovery that t-haplotypes consist of a series of inversions—an over-the-Century Project4. Developmental genetics and recessive t-lethals5. More population genetics with particular attention to the effects of t-allele mediated transmission ratio distortion6. Mutation studies including those targeting the T/t-complex—a century long project7. Immunogenetics and the failed search for t-antigens–from mid-century and continuing to it’s end8. Gametogenesis and the genetics of gametes, including t-haplotype segregation distortion9. The cloning era and the cloning of Brachury and other T/t complex genes10. X-inactivation, epigenetics, and imprinting, including of the T/t complex11. Sex determination, sex differentiation, and the Y chromosome—a mostly last quarter of the century effort12. Pharmacogenetics—a mostly last half of the century effortBook Bibliography