The NMDA Receptor

Häftad, Engelska, 1995

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Beskrivning

This book comprises an up-to-date and comprehensive coverage of the NMDA receptor. The NMDA receptor is an important protein in the brain which is involved in physiological processes such as synaptic transmission and synaptic plasticity which may underlie learning and memory. Pathological changes involving the NMDA receptors probably contribute to the development of epilepsy, acute neuronal damage such as that resulting from stroke and chronic neuropathologies such as Alzheimer's disease. There is considerable interest in the development of pharmacological agents active at NMDA receptors as new therapeutic agents.Each chapter in this book has been prepared by a leading expert in the field and has been fully updated to cover recent developments in the molecular biology and the molecular pharmacology of the NMDA receptor. This is the only book of its kind in the world.

Produktinformation

Utgivningsdatum:1995-02-09
Mått:155 x 234 x 31 mm
Vikt:887 g
Format:Häftad
Språk:Engelska
Antal sidor:518
Upplaga:2
Förlag:OUP OXFORD
ISBN:9780192625021

Utforska kategorier

Biovetenskap inom Naturvetenskap och teknik
Fysiologi inom Medicin
Farmakologi inom Medicin

Recensioner i media

From reviews of the 1st edition:"a welcome text providing a wealth of up-to-date detail for a modest price. Not only the chemical and neuropharmaoological, but also the physiological, clinical neurological and neuropsychological aspects of the NMDA receptor are lucidly and succinctly dealt with. . . Unreservedly recommended reading." Journal of the Neurological Sciences

Innehållsförteckning

2) Agonists and competitive antagonists: structure, activity and molecular modelling studies ; 3) Non-competitive antagonists of N-methyl-D-aspartate ; 4) Molecular pharmacology of NMDA receptors ; 5) Molecular biology of NMDA receptors ; 6) Anatomical, pharmacological, and molecular diversity of native NMDA receptor subtypes ; 7) The NMDA receptor, its channel, and its modulation by glycine ; 8) The time-course of NMDA receptor-mediated synaptic currents ; 9) Activation of NMDA receptors ; 10) NMDA receptors and their interactions with other excitatory amino acid receptors in synaptic transmission in the mammalian central nervous system ; 11) The importance of NMDA receptors in the processing of spinal primary afferent input patterns ; 12 ) The role of NMDA receptors in synaptic integration and the organization of motor patterns ; 13) NMDA receptors and long-term potentiation in the hippocampus ; 14) NMDA receptors and developmental plasticity in visual neocortex ; 15) The role of NMDA receptors in learning and memory ; 16) Clinical implications of NMDA receptors ; 17) The NMDA receptor in epilepsy ; 18) NMDA receptors, neuronal development, and neurodegeneration ; 19) Competitive NMDA antagonists as drugs ; 20) Non-competitive NMDA antagonists as drugs ; 1) The NMDA receptor concept: origins and development