"The editors have assembled a fascinatingly diverse set of contributions by leading experts on topics ranging from sequence analysis, structural studies, and expression analysis to exploring molecular interaction networks, their influence on phenotypes, and their applications to fundamental problems such as physiology, development and evolution. These two volumes provide a well-timed and reasonably comprehensive account of major areas in the emerging subject ofsystems biology."--The Quarterly Review of Biology

• 1: Stanley L. Miller & H. James Cleaves: Prebiotic Chemistry on the Primitive Earth 3 2: Antonio Lazcano: Prebiotic Evolution and the Origin of Life: Is a System-Level Understanding Feasible? 57 3: Granger Sutton & Ian Dew: Shotgun Fragment Assembly 79 4: John Besemer & Mark Borodovsky: Gene Finding 118 5: Temple F. Smith: Local Sequence Similarities 154 6: Michael Y. Galperin & Eugene V. Koonin: Complete Prokaryotic Genomes: Reading and Comprehension 166 7: Jeffrey Skolnick & Yang Zhang: Protein Structure Prediction 187 8: Gary D. Stormo: DNA-Protein Interactions 219 9: Michael Syvanen: Some Computational Problems Associated with Horizontal Gene Transfer 248 10: Noncoding RNA and RNA Regulatory Networks in the Systems Biology of Animals 269 John S. Mattick: Index 303

"The editors have assembled a fascinatingly diverse set of contributions by leading experts on topics ranging from sequence analysis, structural studies, and expression analysis to exploring molecular interaction networks, their influence on phenotypes, and their applications to fundamental problems such as physiology, development and evolution. These two volumes provide a well-timed and reasonably comprehensive account of major areas in the emerging subject ofsystems biology."--The Quarterly Review of Biology

• 1: Stanley L. Miller & H. James Cleaves: Prebiotic Chemistry on the Primitive Earth 3 2: Antonio Lazcano: Prebiotic Evolution and the Origin of Life: Is a System-Level Understanding Feasible? 57 3: Granger Sutton & Ian Dew: Shotgun Fragment Assembly 79 4: John Besemer & Mark Borodovsky: Gene Finding 118 5: Temple F. Smith: Local Sequence Similarities 154 6: Michael Y. Galperin & Eugene V. Koonin: Complete Prokaryotic Genomes: Reading and Comprehension 166 7: Jeffrey Skolnick & Yang Zhang: Protein Structure Prediction 187 8: Gary D. Stormo: DNA-Protein Interactions 219 9: Michael Syvanen: Some Computational Problems Associated with Horizontal Gene Transfer 248 10: Noncoding RNA and RNA Regulatory Networks in the Systems Biology of Animals 269 John S. Mattick: Index 303

"The editors have assembled a fascinatingly diverse set of contributions by leading experts on topics ranging from sequence analysis, structural studies, and expression analysis to exploring molecular interaction networks, their influence on phenotypes, and their applications to fundamental problems such as physiology, development and evolution. These two volumes provide a well-timed and reasonably comprehensive account of major areas in the emerging subject ofsystems biology."--The Quarterly Review of Biology

• 1: Stanley L. Miller & H. James Cleaves: Prebiotic Chemistry on the Primitive Earth 3 2: Antonio Lazcano: Prebiotic Evolution and the Origin of Life: Is a System-Level Understanding Feasible? 57 3: Granger Sutton & Ian Dew: Shotgun Fragment Assembly 79 4: John Besemer & Mark Borodovsky: Gene Finding 118 5: Temple F. Smith: Local Sequence Similarities 154 6: Michael Y. Galperin & Eugene V. Koonin: Complete Prokaryotic Genomes: Reading and Comprehension 166 7: Jeffrey Skolnick & Yang Zhang: Protein Structure Prediction 187 8: Gary D. Stormo: DNA-Protein Interactions 219 9: Michael Syvanen: Some Computational Problems Associated with Horizontal Gene Transfer 248 10: Noncoding RNA and RNA Regulatory Networks in the Systems Biology of Animals 269 John S. Mattick: Index 303