Ion Channel Pharmacology

Inbunden, Engelska, 1998

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Beskrivning

Molecular biology techniques have led to increased understanding of ion channel structure which has opened the way for the development of new drugs targeted at specific types of ion channels. This book aims to provide a fully comprehensive, single-volume overview of the effects of different drugs and toxins on ionic channels, with every chapter providing a detailed description of the pharmacology of each particular ion channel. It will be an essential reference tool for all researchers in this topical and fast-moving subject area.

Produktinformation

Utgivningsdatum:1998-02-26
Mått:176 x 248 x 30 mm
Vikt:1 072 g
Format:Inbunden
Språk:Engelska
Antal sidor:486
Förlag:OUP OXFORD
ISBN:9780198523604

Utforska kategorier

Innehållsförteckning

Part I - Development ; Ch 1 - Neurotrophic factors and development of ionic channels in primary sensory neurons on the ear ; Part II - Sodium channels ; Ch 2 - Chemical modulation of sodium channels ; Ch 3 - Antiarrhythmic action of drugs interacting with sodium channels ; Part III - Calcium channels ; Ch 4 - Biophysics of voltage-dependent Ca2+ channels: gating kinetics and their modulation ; Ch 5 - Pharmacology of voltage-dependent calcium channels ; Ch 6 - Ion channels formed by amyloid B protein (ABP[1-40]). Pharmacology and therapeutic implications for Alzheimer's Disease ; Part IV - Potassium channels ; Ch 7 - The biophysical basis of potassium pharmacology ; Ch 8 - Peptide toxins interacting with potassium channels ; Ch 9 - Properties of the ATP-refulated K+ channel in pancreatic B-cells ; Ch 10 - Potential role of the pharmacology of potassium channels in therapeutics ; Part V - Chloride channels ; Ch 11 - Chloride channel pharmacology ; Part VI - Mechano-gated channels ; Ch 12 - Drug effects on mechano-gated channels ; Part VII - Intracellular channels ; Ch 13 - Intracellular channels in muscle ; Ch 14 - Basic properties of calcium release channels in neural cells ; Ch 15 - Mitochondrial membrane channels and their pharmacology ; Ch 16 - Modulation of a large conductance K+ channel; from chromaffin granule membranes by adrenergic agonists and G-proteins ; Part VIII - Cyclic nucleotide-gated channels ; Ch 17 - Cyclic nucleotide gated ion channels. Physiology, pharmacology and molecular biology ; Part IX - Receptor-operated channels ; Ch 18 - Excitatory animoacid-activated channels ; Ch 19 - Comparison of native and recombinant NMDA receptor channels ; Ch 20 - A unified theory of antidepressant action: evidence for adaptation of the N-methyl-D-aspartate (NMDA) receptor following chronic antidepressant treatments ; Ch 21 - Excitatory synaptic transmission in hippocampus: modulation by purinoceptors via Ca2+ channels