Single-Molecule Studies of Nucleic Acids and Their Proteins

Inbunden, Engelska, 2018

973 kr

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Beskrivning

This book provides the basis for understanding the elastic properties of nucleic acids (DNA, RNA), the methods used to manipulate them (e.g. optical, magnetic and acoustic tweezers and traps), and how to observe their interactions with proteins (e.g. fluorescence microscopy, FCS, FRET, etc.). It then exemplifies the use of these various methods in the study of three families of DNA enzymes: polymerases, helicases and topoisomerases. The book aims not to be exhaustive, but rather to stimulate the imagination of readers in the application of these single molecule approaches to the study of DNA/RNA and their interactions.

Produktinformation

Utgivningsdatum:2018-12-26
Mått:178 x 249 x 17 mm
Vikt:614 g
Format:Inbunden
Språk:Engelska
Serie:Oxford Graduate Texts
Antal sidor:240
Förlag:OUP OXFORD
ISBN:9780198530923

Utforska kategorier

Biokemi inom Naturvetenskap och teknik
Materietillstånd inom Naturvetenskap och teknik
Biologi inom Naturvetenskap och teknik

Mer om författaren

David Bensimon and Vincent Croquette have been co-leaders of a group at the LPS-ENS that has been studying single DNA molecules and their interactions with proteins since 1991. Jean-François Allemand, Terence Strick and Xavier Michalet have been their students and collaborators ever since. They have jointly developed magnetic traps and have been studying various aspects of single molecule DNA/protein transactions. Since joining the lab of Professor S. Weiss at UCLA , Xavier Michalet has been focusing on the use of fluorescent and spectroscopic methods to study single biomolecules.

Recensioner i media

this book is helpful for different audiences... The volume is very well written and enjoyable to read.

Innehållsförteckning

1: Introduction to DNA 2: Manipulating DNA 3: Fluorescence Spectroscopy and Microscopy Techniques 4: The Mechanical Properties of Nucleic Acids 5: Structural Transitions in DNA 6: Single Molecule Studies of DNA-associated Motors 7: DNA and RNA Polymerases 8: DNA Helicases 9: Topoisomerases 10: Conclusions