"This book is not only well organized and well written, but it lives up to its goal of being practical and comprehensive. It is an important resource for anyone interested in sleep medicine. This is definitely a reference that will be used on a regular basis." --©Doody’s Review Service, 2022, Lawrence W Brown, MD (The Children's Hospital of Philadelphia), Doody's Score: 5 Stars!

• 1 Normal Sleep and Its Variants1. History of Sleep Physiology and Medicine2. Normal Human Sleep: An Overview3. Normal Aging4. Daytime Sleepiness and Alertness5. Sleep Deprivation2 Sleep Mechanisms and Phylogeny6. Introduction/Defining Sleep7. Neural Control of Sleep in Mamma Is8. Rapid Eye Movement Sleep Control and Function9. Deep-Brain Imaging of Brain Neurons and Glia during Sleep10. Evolution of Mammalian Sleep11. Sleep in Nonmammalian Vertebrates3 Genetics and Genomic Basis of Sleep12. Introduction: Genetics and Genomics of Sleep13. Genetics and Genomics of Circadian Clocks14. Genetics and Genomic Basis of Sleep in Simple Model Organisms15. Genetic and Genomic Basis of Sleep in Rodents16. Genetics and Genomic Basis of Sleep in Healthy Humans17. Genetics and Genomic Basis of Sleep Disorders in Humans4 Physiology in Sleep18. Introduction to Physiology in Sleep19. What Neuroimaging Reveals about the Brain Areas Generating, Maintaining, and Regulating Sleep20. Cardiovascular Physiology and Coupling with Respiration: Central and Autonomic Regulation21. Cardiovascular Physiology: Autonomic Control in Health and in Sleep Disorders22. Respiratory Physiology. Central Neural Control of Respiratory Neurons and Motoneurons during Sleep23. Respiratory Physiology Understanding the Control of Ventilation24. Physiology of Upper and lower Airways25. 5 Respiratory Physiology Sleep at High Altitude26. Sleep and Host Defense27. Endocrine Physiology in Relation to Sleep and Sleep Disturbances28. Thermoregulation in Sleep and Hibernation29. Memory Processing in Relation to Sleep30. Sensory and Motor Processing during Sleep and Wakefulness31. Local and Use-Dependent Aspects of Sleep32. Pathophysiology of Sleep-Wake Disturbances after Traumatic Brain Injury5 Chronobiology33. Introduction34. Master Circadian Clock and Master Circadian Rhythm35. Anatomy of the Mammalian Circadian Sys tern36. Physiology of the Mammalian Circadian System37. Human Circadian Timing System and Sleep-Wake Regulation38. Sleep Homeostasis and Models of Sleep Regulation39. Circadian Rhythms in Sleepiness, Alertness, and Performance40. Central and Peripheral Circadian Clocks41. Circadian Dysregulation and Cardiometabolic and Immune Health42. Circadian Dysregulation in Brain Aging and Neuropsychiatrie Health43. Circadian Disorders of the Sleep-Wake Cycle6 Pharmacology44. Introduction45. Adenosinergic Control of Sleep46. Catecholamines47. GABA: Its Metabolism, Receptors, and the Drugs for Treating Insomnias and Hypersomnias48. Histamine49. Orexin/Hypocretin50. Serotonin and Sleep51. Melatonin52. Opioid Actions on Sleep and Breathing53. Clinical Pharmacology of Drugs that Affect Sleep and Wake7 Psychobiology and Dreaming54. Introduction55. Why We Dream56. Dream Content: Quantitative Findings57. Neural Correlates of Dreaming58. The Neurobiology of Dreaming59. Lucid Dreaming60. What Is the Function of Nightmares?61. Dreams and Nightmares in Posttraumatic Stress Disorder62. Incorporation of Waking Experiences into Dreams63. Emotion, Motivation, and Reward in Relation to Dreaming64. Dreaming during Pregnancy8 Impact, Presentation, and Diagnosis65. Approach to the Patient with Disordered Sleep66. Cardinal Manifestations of Sleep Disorders67. Physical Examination in Sleep Medicine68. Clinical Tools and Tests in Sleep Medicine69. Classification of Sleep Disorders70. Epidemiology of Sleep Medicine71. Sleep Medicine, Public Policy, and Public Health9 Legal Aspects of Sleep Medicine72. Introduction73. Sleep Forensics: Criminal Culpability for Sleep-Related Violence74. Legal Obligations of Persons Who Have Sleep Disorders or Who Treat or Hire Them75. Legal Aspects of Fatigue- and Safety-Sensitive Professions76. Sleep Medicine Clinical Practice and Compliance- United States77. Sleep Medicine Clinical Practice and Compliance-Europe10 Occupational Sleep Medicine78. Introduction79. Performance Deficits During Sleep Loss and Their Operational Consequences80. Sleep and Sleep Disorders in Operational Settings81. Shift Work, Shift-Work Disorder, Jet Lag. and Jet Lag Disorder82. Fatigue Countermeasures83. Sleep, Sleepiness, and Performance Prediction Modeling84. Fatigue Risk Management Systems85. Safety Cases and Assessing Alternative Means of Regulatory Compliance in Fatigue Risk Management86. Fatigue Proofing87. Sleep Health in Athlete Populations: Unique Challenges and Practical Solutions88. Assessment of the Occupational Sleep Medicine Field11 Insomnia89. Advances in Insomnia Pathophysiology and Treatment: An Introduction90. Insomnia: Epidemiology, Risk Factors, and Health Disparities91. Etiology and Pathophysiology of Insomnia92. Pediatric Insomnia and Its Developmental Trajectories93. Insomnia Diagnosis, Assessment, and Evaluation94. Insomnia with Short Sleep Duration and Multidimensional Sleep Health95. Behavioral Treatment I: Therapeutic Approaches and Implementation96. Behavioral Treatment II: Efficacy, Effectiveness, and Dissemination97. Behavioral Treatment III: Digital and Telehealth Approaches98. Pharmacologic Treatment I: Therapeutic Approaches and Implementation99. Pharmacologic Treatment II: Efficacy, Effectiveness, and Contraindications100. Pharmacologic Treatment III: Sequenced and Combined Psychologic and Pharmacologic Treatments for Insomnia12 Neurologic Disorders101. Introduction102. Parkinsonism103. Sleep-Wake Disturbances and Stroke104. Sleep and Neuromuscular Diseases105. Alzheimer Disease and Other Demen tias106. Epilepsy, Sleep, and Sleep Disorders107. Sleep and Headache108. Sleep Disorders after Traumatic Brain Injury109. Autoimmune Disorders (Autoimmune Encephalitides and Multiple Sclerosis)13 Hypersomnias110. Central Disorders of Hypersomnolence111. Narcolepsy: Pathophysiology and Genetic Predisposition112. Narcolepsy: Diagnosis and Management113. Idiopathic Hypersomnia114. Kleine-Levin Syndrome14 Parasomnias115. Parasomnias and Sleep-Related Movement Disorders: Overview and Approach116. Disorders of Arousal117. Sleep-Related Eating Disorder118. Rapid Eye Movement Sleep Parasomnias119. Nightmares and Dream Disturbances120. Other Parasomnias121. Restless Legs Syndrome /Willis-Ekbom Disease) and Periodic Limb Movements during Sleep122. Sleep-Related Movement Disorders and Their Unique Motor Manifestations15 Sleep Breathing Disorders123. Introduction124. Central Sleep Apnea: Definitions, Pathophysiology, Genetics, and Epidemiology125. Central Sleep Apnea: Diagnosis and Management126. Anatomy and Physiology of Upper Airway Obstruction127. Snoring and Pathologic Upper Airway Resistance Syndromes128. Obstructive Sleep Apnea: Heritable Phenotypes and Genetics129. Deep Phenotyping of Sleep Apnea130. Clinical and Physiologic Heterogeneity of Obstructive Sleep Apnea131. Obstructive Sleep Apnea: Clinical Features, Evaluation, and Principles of Management132. Positive Airway Pressure Treatment for Obstructive Sleep Apnea133. Pharmacologic Treatments for Obstructive Sleep Apnea134. Alternative Strategies to Management of Sleep-Disordered Breathing135. Brain Health in Sleep Apnea: Cognition, Performance, Mechanisms, and Treatment136. Obstructive Sleep Apnea and Metabolic Disorders137. Overlap Syndromes of Sleep and Breathing Disorders138. Obesity-Hypoventilation Syndrome139. Obstructive Sleep Apnea, Obesity, and Bariatric Surgery140. Advanced Modes of Positive Pressure Therapy for Sleep-Disordered Breathing141. Sleep and Breathing at High Altitude142. Evolution of Sleep-Disordered Breathing across the Adult Years16 Cardiovascular Disorders143. Introduction144. Sleep-Related Cardiac Risk145. Cardiac A rrhythmogenesis during Sleep: Mechanisms, Diagnosis, and Therapy146. Cardiovascular Effects of Sleep-Related Breathing Disorders147. Systemic and Pulmonary Hypertension in Obstructive Sleep Apnea148. Coronary Artery Disease and Obstructive Sleep Apnea149. Heart Failure150. Sleep-Disordered Breathing and Stroke151. Insomnia and Cardiovascular Disease17 Other Medical Disorders152. Introduction153. Sleep and Cancer across the Life Span154. Fibromyalgia and Chronic Fatigue Syndromes155. Endocrine Disorders156. Pain and Sleep157. Sleep and Chronic Kidney Disease158. Sleep in the Critically III Patient159. Perioperative Sleep Medicine160. Sleep and Gastrointestinal Health18 Psychiatric Disorders161. Introduction162. Emotion and Sleep163. Anxiety Disorders and Posttraumatic Stress Disorder164. Affearve Disorders165. Schizophrenia and Sleep166. Substance Abuse19 Dentistry and Otorhinolaryngology167. Dentistry and Otorhinolaryngology in Sleep Medicine: Below the BraiAtttpd Above the Larynx168. Oronasopharyngeal Growth and Malformations with Orthodontic Management169. Sleep Bruxism: Definition, Prevalence, Classification, Etiology, and Consequences170. Assessment of Sleep Bruxism171. Management of Sleep Bruxism: Psychological, DentaL and Medical Approaches in Adults172. Orofacial Pain/Temporomandibular Disorders in Relation to Sleep Bruxism and Breathing Disorders173. Oral Appliances for the Treatment of Sleep-Disordered Breathing174. Anesthesia in Upper Airway Surgery175. Upper Airway Surgery to Treat Obstructive Sleep- Disordered Breathing176. Pharmacotherapy and Behavioral Complementary, and Alternative Medicine for Sleep Bruxism20 From Childhood to Adulthood177. Overview: Transition from Pediatric-Oriented to Adult-Oriented Health Care in Sleep Medicine178. Sleep-Related Breathing Disorders in Children179. Neuromuscular and Neurological Disorders180. Transitional Care for Adolescents with Narcolepsy and Other Central Disorders of Hypersomnolence181. Congenital Heart Disease182. Sleep in Intersex and Transgender Individuals21 Sleep in Women183. Introduction184. Sex Effects and Differences in Circadian Rhythms and Sleep185. The Menstrual Cycle, Sleep, and Circadian Rhythms186. Sleep and Sleep Disorders Associated with Pregnancy187. Sleep-Disordered Breathing in Pregnancy188. Postpartum Period and Early Parenthood189. Sleep and Menopause22 Sleep Medicine in the Elderly190. Introduction191. Psychiatric and Medical Comorbidities and Effects of Medications in Older Adults192. Obstructive Sleep Apnea in Older Adults193. Insomnia in Older Adults194. Orcadian Rhythms in Older Adults195. Sleep in Long-Term Care Settings23 Methodology196. Section Introduction: Polysomnography and Beyond197. Sleep Stage Scoring198. Central Nervous System Arousals and the Cyclic Alternating Pattern199. Neurologic Monitoring Techniques200. Monitoring Techniques for Evaluating Suspected Sleep-Related Breathing and Cardiovascular Disorders201. Sleep Telemedicine and Remote PAP Adherence Monitoring202. Cardiopulmonary Coupling203. Pulse Wave Analysis204. Recording and Scoring Sleep-Related Movements205. Home Sleep Testing for Sleep-Related Breathing Disorders206. Consumer Sleep Tracking: Landscape and CTA/ANSI Performance Standards207. Evaluating Sleepiness and Fatigue208. The Assessment of Insomnia209. Surveys, Sampling, and Polling Methods for Sleep and Public Health210. Techniques for Clinical Assessment of Circadian Rhythm Disorders211. Actigraphy Methods and Technical Issues212. Imaging213. COVID-19 and Sleep

"This book is not only well organized and well written, but it lives up to its goal of being practical and comprehensive. It is an important resource for anyone interested in sleep medicine. This is definitely a reference that will be used on a regular basis." --©Doody’s Review Service, 2022, Lawrence W Brown, MD (The Children's Hospital of Philadelphia), Doody's Score: 5 Stars!

• 1 Normal Sleep and Its Variants1. History of Sleep Physiology and Medicine2. Normal Human Sleep: An Overview3. Normal Aging4. Daytime Sleepiness and Alertness5. Sleep Deprivation2 Sleep Mechanisms and Phylogeny6. Introduction/Defining Sleep7. Neural Control of Sleep in Mamma Is8. Rapid Eye Movement Sleep Control and Function9. Deep-Brain Imaging of Brain Neurons and Glia during Sleep10. Evolution of Mammalian Sleep11. Sleep in Nonmammalian Vertebrates3 Genetics and Genomic Basis of Sleep12. Introduction: Genetics and Genomics of Sleep13. Genetics and Genomics of Circadian Clocks14. Genetics and Genomic Basis of Sleep in Simple Model Organisms15. Genetic and Genomic Basis of Sleep in Rodents16. Genetics and Genomic Basis of Sleep in Healthy Humans17. Genetics and Genomic Basis of Sleep Disorders in Humans4 Physiology in Sleep18. Introduction to Physiology in Sleep19. What Neuroimaging Reveals about the Brain Areas Generating, Maintaining, and Regulating Sleep20. Cardiovascular Physiology and Coupling with Respiration: Central and Autonomic Regulation21. Cardiovascular Physiology: Autonomic Control in Health and in Sleep Disorders22. Respiratory Physiology. Central Neural Control of Respiratory Neurons and Motoneurons during Sleep23. Respiratory Physiology Understanding the Control of Ventilation24. Physiology of Upper and lower Airways25. 5 Respiratory Physiology Sleep at High Altitude26. Sleep and Host Defense27. Endocrine Physiology in Relation to Sleep and Sleep Disturbances28. Thermoregulation in Sleep and Hibernation29. Memory Processing in Relation to Sleep30. Sensory and Motor Processing during Sleep and Wakefulness31. Local and Use-Dependent Aspects of Sleep32. Pathophysiology of Sleep-Wake Disturbances after Traumatic Brain Injury5 Chronobiology33. Introduction34. Master Circadian Clock and Master Circadian Rhythm35. Anatomy of the Mammalian Circadian Sys tern36. Physiology of the Mammalian Circadian System37. Human Circadian Timing System and Sleep-Wake Regulation38. Sleep Homeostasis and Models of Sleep Regulation39. Circadian Rhythms in Sleepiness, Alertness, and Performance40. Central and Peripheral Circadian Clocks41. Circadian Dysregulation and Cardiometabolic and Immune Health42. Circadian Dysregulation in Brain Aging and Neuropsychiatrie Health43. Circadian Disorders of the Sleep-Wake Cycle6 Pharmacology44. Introduction45. Adenosinergic Control of Sleep46. Catecholamines47. GABA: Its Metabolism, Receptors, and the Drugs for Treating Insomnias and Hypersomnias48. Histamine49. Orexin/Hypocretin50. Serotonin and Sleep51. Melatonin52. Opioid Actions on Sleep and Breathing53. Clinical Pharmacology of Drugs that Affect Sleep and Wake7 Psychobiology and Dreaming54. Introduction55. Why We Dream56. Dream Content: Quantitative Findings57. Neural Correlates of Dreaming58. The Neurobiology of Dreaming59. Lucid Dreaming60. What Is the Function of Nightmares?61. Dreams and Nightmares in Posttraumatic Stress Disorder62. Incorporation of Waking Experiences into Dreams63. Emotion, Motivation, and Reward in Relation to Dreaming64. Dreaming during Pregnancy8 Impact, Presentation, and Diagnosis65. Approach to the Patient with Disordered Sleep66. Cardinal Manifestations of Sleep Disorders67. Physical Examination in Sleep Medicine68. Clinical Tools and Tests in Sleep Medicine69. Classification of Sleep Disorders70. Epidemiology of Sleep Medicine71. Sleep Medicine, Public Policy, and Public Health9 Legal Aspects of Sleep Medicine72. Introduction73. Sleep Forensics: Criminal Culpability for Sleep-Related Violence74. Legal Obligations of Persons Who Have Sleep Disorders or Who Treat or Hire Them75. Legal Aspects of Fatigue- and Safety-Sensitive Professions76. Sleep Medicine Clinical Practice and Compliance- United States77. Sleep Medicine Clinical Practice and Compliance-Europe10 Occupational Sleep Medicine78. Introduction79. Performance Deficits During Sleep Loss and Their Operational Consequences80. Sleep and Sleep Disorders in Operational Settings81. Shift Work, Shift-Work Disorder, Jet Lag. and Jet Lag Disorder82. Fatigue Countermeasures83. Sleep, Sleepiness, and Performance Prediction Modeling84. Fatigue Risk Management Systems85. Safety Cases and Assessing Alternative Means of Regulatory Compliance in Fatigue Risk Management86. Fatigue Proofing87. Sleep Health in Athlete Populations: Unique Challenges and Practical Solutions88. Assessment of the Occupational Sleep Medicine Field11 Insomnia89. Advances in Insomnia Pathophysiology and Treatment: An Introduction90. Insomnia: Epidemiology, Risk Factors, and Health Disparities91. Etiology and Pathophysiology of Insomnia92. Pediatric Insomnia and Its Developmental Trajectories93. Insomnia Diagnosis, Assessment, and Evaluation94. Insomnia with Short Sleep Duration and Multidimensional Sleep Health95. Behavioral Treatment I: Therapeutic Approaches and Implementation96. Behavioral Treatment II: Efficacy, Effectiveness, and Dissemination97. Behavioral Treatment III: Digital and Telehealth Approaches98. Pharmacologic Treatment I: Therapeutic Approaches and Implementation99. Pharmacologic Treatment II: Efficacy, Effectiveness, and Contraindications100. Pharmacologic Treatment III: Sequenced and Combined Psychologic and Pharmacologic Treatments for Insomnia12 Neurologic Disorders101. Introduction102. Parkinsonism103. Sleep-Wake Disturbances and Stroke104. Sleep and Neuromuscular Diseases105. Alzheimer Disease and Other Demen tias106. Epilepsy, Sleep, and Sleep Disorders107. Sleep and Headache108. Sleep Disorders after Traumatic Brain Injury109. Autoimmune Disorders (Autoimmune Encephalitides and Multiple Sclerosis)13 Hypersomnias110. Central Disorders of Hypersomnolence111. Narcolepsy: Pathophysiology and Genetic Predisposition112. Narcolepsy: Diagnosis and Management113. Idiopathic Hypersomnia114. Kleine-Levin Syndrome14 Parasomnias115. Parasomnias and Sleep-Related Movement Disorders: Overview and Approach116. Disorders of Arousal117. Sleep-Related Eating Disorder118. Rapid Eye Movement Sleep Parasomnias119. Nightmares and Dream Disturbances120. Other Parasomnias121. Restless Legs Syndrome /Willis-Ekbom Disease) and Periodic Limb Movements during Sleep122. Sleep-Related Movement Disorders and Their Unique Motor Manifestations15 Sleep Breathing Disorders123. Introduction124. Central Sleep Apnea: Definitions, Pathophysiology, Genetics, and Epidemiology125. Central Sleep Apnea: Diagnosis and Management126. Anatomy and Physiology of Upper Airway Obstruction127. Snoring and Pathologic Upper Airway Resistance Syndromes128. Obstructive Sleep Apnea: Heritable Phenotypes and Genetics129. Deep Phenotyping of Sleep Apnea130. Clinical and Physiologic Heterogeneity of Obstructive Sleep Apnea131. Obstructive Sleep Apnea: Clinical Features, Evaluation, and Principles of Management132. Positive Airway Pressure Treatment for Obstructive Sleep Apnea133. Pharmacologic Treatments for Obstructive Sleep Apnea134. Alternative Strategies to Management of Sleep-Disordered Breathing135. Brain Health in Sleep Apnea: Cognition, Performance, Mechanisms, and Treatment136. Obstructive Sleep Apnea and Metabolic Disorders137. Overlap Syndromes of Sleep and Breathing Disorders138. Obesity-Hypoventilation Syndrome139. Obstructive Sleep Apnea, Obesity, and Bariatric Surgery140. Advanced Modes of Positive Pressure Therapy for Sleep-Disordered Breathing141. Sleep and Breathing at High Altitude142. Evolution of Sleep-Disordered Breathing across the Adult Years16 Cardiovascular Disorders143. Introduction144. Sleep-Related Cardiac Risk145. Cardiac A rrhythmogenesis during Sleep: Mechanisms, Diagnosis, and Therapy146. Cardiovascular Effects of Sleep-Related Breathing Disorders147. Systemic and Pulmonary Hypertension in Obstructive Sleep Apnea148. Coronary Artery Disease and Obstructive Sleep Apnea149. Heart Failure150. Sleep-Disordered Breathing and Stroke151. Insomnia and Cardiovascular Disease17 Other Medical Disorders152. Introduction153. Sleep and Cancer across the Life Span154. Fibromyalgia and Chronic Fatigue Syndromes155. Endocrine Disorders156. Pain and Sleep157. Sleep and Chronic Kidney Disease158. Sleep in the Critically III Patient159. Perioperative Sleep Medicine160. Sleep and Gastrointestinal Health18 Psychiatric Disorders161. Introduction162. Emotion and Sleep163. Anxiety Disorders and Posttraumatic Stress Disorder164. Affearve Disorders165. Schizophrenia and Sleep166. Substance Abuse19 Dentistry and Otorhinolaryngology167. Dentistry and Otorhinolaryngology in Sleep Medicine: Below the BraiAtttpd Above the Larynx168. Oronasopharyngeal Growth and Malformations with Orthodontic Management169. Sleep Bruxism: Definition, Prevalence, Classification, Etiology, and Consequences170. Assessment of Sleep Bruxism171. Management of Sleep Bruxism: Psychological, DentaL and Medical Approaches in Adults172. Orofacial Pain/Temporomandibular Disorders in Relation to Sleep Bruxism and Breathing Disorders173. Oral Appliances for the Treatment of Sleep-Disordered Breathing174. Anesthesia in Upper Airway Surgery175. Upper Airway Surgery to Treat Obstructive Sleep- Disordered Breathing176. Pharmacotherapy and Behavioral Complementary, and Alternative Medicine for Sleep Bruxism20 From Childhood to Adulthood177. Overview: Transition from Pediatric-Oriented to Adult-Oriented Health Care in Sleep Medicine178. Sleep-Related Breathing Disorders in Children179. Neuromuscular and Neurological Disorders180. Transitional Care for Adolescents with Narcolepsy and Other Central Disorders of Hypersomnolence181. Congenital Heart Disease182. Sleep in Intersex and Transgender Individuals21 Sleep in Women183. Introduction184. Sex Effects and Differences in Circadian Rhythms and Sleep185. The Menstrual Cycle, Sleep, and Circadian Rhythms186. Sleep and Sleep Disorders Associated with Pregnancy187. Sleep-Disordered Breathing in Pregnancy188. Postpartum Period and Early Parenthood189. Sleep and Menopause22 Sleep Medicine in the Elderly190. Introduction191. Psychiatric and Medical Comorbidities and Effects of Medications in Older Adults192. Obstructive Sleep Apnea in Older Adults193. Insomnia in Older Adults194. Orcadian Rhythms in Older Adults195. Sleep in Long-Term Care Settings23 Methodology196. Section Introduction: Polysomnography and Beyond197. Sleep Stage Scoring198. Central Nervous System Arousals and the Cyclic Alternating Pattern199. Neurologic Monitoring Techniques200. Monitoring Techniques for Evaluating Suspected Sleep-Related Breathing and Cardiovascular Disorders201. Sleep Telemedicine and Remote PAP Adherence Monitoring202. Cardiopulmonary Coupling203. Pulse Wave Analysis204. Recording and Scoring Sleep-Related Movements205. Home Sleep Testing for Sleep-Related Breathing Disorders206. Consumer Sleep Tracking: Landscape and CTA/ANSI Performance Standards207. Evaluating Sleepiness and Fatigue208. The Assessment of Insomnia209. Surveys, Sampling, and Polling Methods for Sleep and Public Health210. Techniques for Clinical Assessment of Circadian Rhythm Disorders211. Actigraphy Methods and Technical Issues212. Imaging213. COVID-19 and Sleep

"This book is not only well organized and well written, but it lives up to its goal of being practical and comprehensive. It is an important resource for anyone interested in sleep medicine. This is definitely a reference that will be used on a regular basis." --©Doody’s Review Service, 2022, Lawrence W Brown, MD (The Children's Hospital of Philadelphia), Doody's Score: 5 Stars!

• 1 Normal Sleep and Its Variants1. History of Sleep Physiology and Medicine2. Normal Human Sleep: An Overview3. Normal Aging4. Daytime Sleepiness and Alertness5. Sleep Deprivation2 Sleep Mechanisms and Phylogeny6. Introduction/Defining Sleep7. Neural Control of Sleep in Mamma Is8. Rapid Eye Movement Sleep Control and Function9. Deep-Brain Imaging of Brain Neurons and Glia during Sleep10. Evolution of Mammalian Sleep11. Sleep in Nonmammalian Vertebrates3 Genetics and Genomic Basis of Sleep12. Introduction: Genetics and Genomics of Sleep13. Genetics and Genomics of Circadian Clocks14. Genetics and Genomic Basis of Sleep in Simple Model Organisms15. Genetic and Genomic Basis of Sleep in Rodents16. Genetics and Genomic Basis of Sleep in Healthy Humans17. Genetics and Genomic Basis of Sleep Disorders in Humans4 Physiology in Sleep18. Introduction to Physiology in Sleep19. What Neuroimaging Reveals about the Brain Areas Generating, Maintaining, and Regulating Sleep20. Cardiovascular Physiology and Coupling with Respiration: Central and Autonomic Regulation21. Cardiovascular Physiology: Autonomic Control in Health and in Sleep Disorders22. Respiratory Physiology. Central Neural Control of Respiratory Neurons and Motoneurons during Sleep23. Respiratory Physiology Understanding the Control of Ventilation24. Physiology of Upper and lower Airways25. 5 Respiratory Physiology Sleep at High Altitude26. Sleep and Host Defense27. Endocrine Physiology in Relation to Sleep and Sleep Disturbances28. Thermoregulation in Sleep and Hibernation29. Memory Processing in Relation to Sleep30. Sensory and Motor Processing during Sleep and Wakefulness31. Local and Use-Dependent Aspects of Sleep32. Pathophysiology of Sleep-Wake Disturbances after Traumatic Brain Injury5 Chronobiology33. Introduction34. Master Circadian Clock and Master Circadian Rhythm35. Anatomy of the Mammalian Circadian Sys tern36. Physiology of the Mammalian Circadian System37. Human Circadian Timing System and Sleep-Wake Regulation38. Sleep Homeostasis and Models of Sleep Regulation39. Circadian Rhythms in Sleepiness, Alertness, and Performance40. Central and Peripheral Circadian Clocks41. Circadian Dysregulation and Cardiometabolic and Immune Health42. Circadian Dysregulation in Brain Aging and Neuropsychiatrie Health43. Circadian Disorders of the Sleep-Wake Cycle6 Pharmacology44. Introduction45. Adenosinergic Control of Sleep46. Catecholamines47. GABA: Its Metabolism, Receptors, and the Drugs for Treating Insomnias and Hypersomnias48. Histamine49. Orexin/Hypocretin50. Serotonin and Sleep51. Melatonin52. Opioid Actions on Sleep and Breathing53. Clinical Pharmacology of Drugs that Affect Sleep and Wake7 Psychobiology and Dreaming54. Introduction55. Why We Dream56. Dream Content: Quantitative Findings57. Neural Correlates of Dreaming58. The Neurobiology of Dreaming59. Lucid Dreaming60. What Is the Function of Nightmares?61. Dreams and Nightmares in Posttraumatic Stress Disorder62. Incorporation of Waking Experiences into Dreams63. Emotion, Motivation, and Reward in Relation to Dreaming64. Dreaming during Pregnancy8 Impact, Presentation, and Diagnosis65. Approach to the Patient with Disordered Sleep66. Cardinal Manifestations of Sleep Disorders67. Physical Examination in Sleep Medicine68. Clinical Tools and Tests in Sleep Medicine69. Classification of Sleep Disorders70. Epidemiology of Sleep Medicine71. Sleep Medicine, Public Policy, and Public Health9 Legal Aspects of Sleep Medicine72. Introduction73. Sleep Forensics: Criminal Culpability for Sleep-Related Violence74. Legal Obligations of Persons Who Have Sleep Disorders or Who Treat or Hire Them75. Legal Aspects of Fatigue- and Safety-Sensitive Professions76. Sleep Medicine Clinical Practice and Compliance- United States77. Sleep Medicine Clinical Practice and Compliance-Europe10 Occupational Sleep Medicine78. Introduction79. Performance Deficits During Sleep Loss and Their Operational Consequences80. Sleep and Sleep Disorders in Operational Settings81. Shift Work, Shift-Work Disorder, Jet Lag. and Jet Lag Disorder82. Fatigue Countermeasures83. Sleep, Sleepiness, and Performance Prediction Modeling84. Fatigue Risk Management Systems85. Safety Cases and Assessing Alternative Means of Regulatory Compliance in Fatigue Risk Management86. Fatigue Proofing87. Sleep Health in Athlete Populations: Unique Challenges and Practical Solutions88. Assessment of the Occupational Sleep Medicine Field11 Insomnia89. Advances in Insomnia Pathophysiology and Treatment: An Introduction90. Insomnia: Epidemiology, Risk Factors, and Health Disparities91. Etiology and Pathophysiology of Insomnia92. Pediatric Insomnia and Its Developmental Trajectories93. Insomnia Diagnosis, Assessment, and Evaluation94. Insomnia with Short Sleep Duration and Multidimensional Sleep Health95. Behavioral Treatment I: Therapeutic Approaches and Implementation96. Behavioral Treatment II: Efficacy, Effectiveness, and Dissemination97. Behavioral Treatment III: Digital and Telehealth Approaches98. Pharmacologic Treatment I: Therapeutic Approaches and Implementation99. Pharmacologic Treatment II: Efficacy, Effectiveness, and Contraindications100. Pharmacologic Treatment III: Sequenced and Combined Psychologic and Pharmacologic Treatments for Insomnia12 Neurologic Disorders101. Introduction102. Parkinsonism103. Sleep-Wake Disturbances and Stroke104. Sleep and Neuromuscular Diseases105. Alzheimer Disease and Other Demen tias106. Epilepsy, Sleep, and Sleep Disorders107. Sleep and Headache108. Sleep Disorders after Traumatic Brain Injury109. Autoimmune Disorders (Autoimmune Encephalitides and Multiple Sclerosis)13 Hypersomnias110. Central Disorders of Hypersomnolence111. Narcolepsy: Pathophysiology and Genetic Predisposition112. Narcolepsy: Diagnosis and Management113. Idiopathic Hypersomnia114. Kleine-Levin Syndrome14 Parasomnias115. Parasomnias and Sleep-Related Movement Disorders: Overview and Approach116. Disorders of Arousal117. Sleep-Related Eating Disorder118. Rapid Eye Movement Sleep Parasomnias119. Nightmares and Dream Disturbances120. Other Parasomnias121. Restless Legs Syndrome /Willis-Ekbom Disease) and Periodic Limb Movements during Sleep122. Sleep-Related Movement Disorders and Their Unique Motor Manifestations15 Sleep Breathing Disorders123. Introduction124. Central Sleep Apnea: Definitions, Pathophysiology, Genetics, and Epidemiology125. Central Sleep Apnea: Diagnosis and Management126. Anatomy and Physiology of Upper Airway Obstruction127. Snoring and Pathologic Upper Airway Resistance Syndromes128. Obstructive Sleep Apnea: Heritable Phenotypes and Genetics129. Deep Phenotyping of Sleep Apnea130. Clinical and Physiologic Heterogeneity of Obstructive Sleep Apnea131. Obstructive Sleep Apnea: Clinical Features, Evaluation, and Principles of Management132. Positive Airway Pressure Treatment for Obstructive Sleep Apnea133. Pharmacologic Treatments for Obstructive Sleep Apnea134. Alternative Strategies to Management of Sleep-Disordered Breathing135. Brain Health in Sleep Apnea: Cognition, Performance, Mechanisms, and Treatment136. Obstructive Sleep Apnea and Metabolic Disorders137. Overlap Syndromes of Sleep and Breathing Disorders138. Obesity-Hypoventilation Syndrome139. Obstructive Sleep Apnea, Obesity, and Bariatric Surgery140. Advanced Modes of Positive Pressure Therapy for Sleep-Disordered Breathing141. Sleep and Breathing at High Altitude142. Evolution of Sleep-Disordered Breathing across the Adult Years16 Cardiovascular Disorders143. Introduction144. Sleep-Related Cardiac Risk145. Cardiac A rrhythmogenesis during Sleep: Mechanisms, Diagnosis, and Therapy146. Cardiovascular Effects of Sleep-Related Breathing Disorders147. Systemic and Pulmonary Hypertension in Obstructive Sleep Apnea148. Coronary Artery Disease and Obstructive Sleep Apnea149. Heart Failure150. Sleep-Disordered Breathing and Stroke151. Insomnia and Cardiovascular Disease17 Other Medical Disorders152. Introduction153. Sleep and Cancer across the Life Span154. Fibromyalgia and Chronic Fatigue Syndromes155. Endocrine Disorders156. Pain and Sleep157. Sleep and Chronic Kidney Disease158. Sleep in the Critically III Patient159. Perioperative Sleep Medicine160. Sleep and Gastrointestinal Health18 Psychiatric Disorders161. Introduction162. Emotion and Sleep163. Anxiety Disorders and Posttraumatic Stress Disorder164. Affearve Disorders165. Schizophrenia and Sleep166. Substance Abuse19 Dentistry and Otorhinolaryngology167. Dentistry and Otorhinolaryngology in Sleep Medicine: Below the BraiAtttpd Above the Larynx168. Oronasopharyngeal Growth and Malformations with Orthodontic Management169. Sleep Bruxism: Definition, Prevalence, Classification, Etiology, and Consequences170. Assessment of Sleep Bruxism171. Management of Sleep Bruxism: Psychological, DentaL and Medical Approaches in Adults172. Orofacial Pain/Temporomandibular Disorders in Relation to Sleep Bruxism and Breathing Disorders173. Oral Appliances for the Treatment of Sleep-Disordered Breathing174. Anesthesia in Upper Airway Surgery175. Upper Airway Surgery to Treat Obstructive Sleep- Disordered Breathing176. Pharmacotherapy and Behavioral Complementary, and Alternative Medicine for Sleep Bruxism20 From Childhood to Adulthood177. Overview: Transition from Pediatric-Oriented to Adult-Oriented Health Care in Sleep Medicine178. Sleep-Related Breathing Disorders in Children179. Neuromuscular and Neurological Disorders180. Transitional Care for Adolescents with Narcolepsy and Other Central Disorders of Hypersomnolence181. Congenital Heart Disease182. Sleep in Intersex and Transgender Individuals21 Sleep in Women183. Introduction184. Sex Effects and Differences in Circadian Rhythms and Sleep185. The Menstrual Cycle, Sleep, and Circadian Rhythms186. Sleep and Sleep Disorders Associated with Pregnancy187. Sleep-Disordered Breathing in Pregnancy188. Postpartum Period and Early Parenthood189. Sleep and Menopause22 Sleep Medicine in the Elderly190. Introduction191. Psychiatric and Medical Comorbidities and Effects of Medications in Older Adults192. Obstructive Sleep Apnea in Older Adults193. Insomnia in Older Adults194. Orcadian Rhythms in Older Adults195. Sleep in Long-Term Care Settings23 Methodology196. Section Introduction: Polysomnography and Beyond197. Sleep Stage Scoring198. Central Nervous System Arousals and the Cyclic Alternating Pattern199. Neurologic Monitoring Techniques200. Monitoring Techniques for Evaluating Suspected Sleep-Related Breathing and Cardiovascular Disorders201. Sleep Telemedicine and Remote PAP Adherence Monitoring202. Cardiopulmonary Coupling203. Pulse Wave Analysis204. Recording and Scoring Sleep-Related Movements205. Home Sleep Testing for Sleep-Related Breathing Disorders206. Consumer Sleep Tracking: Landscape and CTA/ANSI Performance Standards207. Evaluating Sleepiness and Fatigue208. The Assessment of Insomnia209. Surveys, Sampling, and Polling Methods for Sleep and Public Health210. Techniques for Clinical Assessment of Circadian Rhythm Disorders211. Actigraphy Methods and Technical Issues212. Imaging213. COVID-19 and Sleep