DeGroot's Endocrinology

R. Paul Robertson, M.D. is an Emeritus Professor of Medicine at the University of Washington and at the University of Minnesota.Dr. Robertson has published 395 peer-reviewed manuscripts with primary emphasis on pancreatic islet function in humans, animals, and clonal cell lines. His early studies were the first to demonstrate defects involving the adverse effects of glucose toxicity on the critical insulin promoters Pdx-1 and MafA associated with glucose toxicity. More recent research demonstrated adverse metabolic consequences of using the liver as a transplant site for pancreatic islet transplantation in patients with type 1 diabetes mellitus and in autoislet recipients following pancreatectomy for chronic, painful pancreatitis.

"This book is one of the main reference texts for this specialty. The complete edition comprises two textbooks and is extremely comprehensive, featuring a thorough table of contents and index. This eighth edition book is an update to the previous version, which was published in 2015." --©Doody’s Review Service, 2023 Aileen Westrick, MD (Northwestern Medicine Regional Medical Group) Doody's Score: 4 Stars!

• 1 Principles of Endocrinology2 Regulation of Islet Hormone Synthesis and Secretion2 Principles of Endocrine Measurements3 Applications of Genetics in Endocrinology3 Endocrine-Disrupting Chemicals and Human Disease3 Endocrine Rhythms, the Sleep-Wake Cycle, and Biological Clocks4 Prolactinomas and Disorders of Prolactin Secretion5 Hypopituitarism including Growth Hormone Deficiency6 Acromegaly7 Development of the Pituitary7 Cushing's Disease8 CLINICALLY NONFUNCTIONING SELLAR MASSES9 TSH-Producing Pituitary Tumors10 Pituitary Surgery11 CRANIOPHARYNGIOMAS AND PARASELLAR MASSES12 DISORDERS OF SODIUM, DIABETES INSIPIDUS AND HYPONATRAEMIA13 Anatomy and Physiology of the Hypothalmus and Pituitary14 Genetic Disorders of the Pituitary15 Aggressive Pituitary Tumors16 Radiotherapy in Pituitary Tumors17 Somatic Growth and Maturation: Growth hormone and Other Growth Factors18 Growth Hormone Deficiency in Children19 Basic and Clinical Aspects of Appetite Regulation and Energy Expenditure20 Obesity: Risk, Risk Factors, and Medical Management21 GENETIC OBESITY SYNDROMES22 Regulation of Intermediary Metabolism During Fasting, Feeding, and Exercise23 Adipose Tissue Function: Metabolic and Endocrine24 Lipodystrpohy Syndromes25 Lipoprotein Metabolism and the Treatment of Lipid Disorders26 Metabolic Syndrome27 Bariatric Procedures and Operations28 Development of the Endocrine Pancreas29 Regulation of Islet Hormone Synthesis and Secretion30 Mechanisms of Insulin Action31 Classification and Diagnosis of Diabetes Mellitus32 Autoimmune (Type 1)Diabetes Mellitus: Etiology, Pathogenesis, Prediction, and Prevention33 Type 2 Diabetes Mellitus: Etiology, Pathogenesis, and Natural History34 Diabetes Mellitus and Pregnancy35 Hyperglycemia Secondary to Non-Traditional Diabetic Conditions and Therapies36 Beta-cell Glucose Toxicity and Oxidative Stress37 DIABETIC KETOACIDOSIS AND HYPERGLYCEMIC HYPEROSMOLAR STATE38 Hypoglycemia and Hypoglycemic Syndromes39 Treatment of Type 1 Diabetes Mellitus in Adults40 Clinical Management of Type 2 Diabetes Mellitus41 Pancreas and Islet Transplantation42 Diabetes and Long-Term Complications43 Diabetic Eye Disease44 Diabetic Neuropathy45 Glucose Sensors and Insulin Pumps45 Diabetic Kidney Disease46 Diabetic Foot and Vascular Complications47 Parathyroid Hormone and the Parathyroid Hormone Receptor Type 1 in the Regulation of Calcium and Phosphate Homeostasis and Bone Metabolism48 Parathyroid Hormone-Related Protein49 Calcitonin50 Vitamin D: From Photosynthesis, Metabolism, and Action to Clinical Applications51 Bone Development and Remodeling52 Regulation of Calcium Homeostasis and Genetic Disorders that Affect Calcium Metabolism53 Genetic Disorders of Phosphate Homeostasis54 Primary Hyperparathyroidism55 Hypercalcemia of Malignancy56 Surgical Management of Hyperparathyroidism57 PSEUDOHYPOPARATHYROIDISM, ALBRIGHT’S HEREDITARY OSTEODYSTROPHY, AND PROGRESSIVE OSSEOUS HETEROPLASIA: DISORDERS CAUSED BY GNAS MUTATIONS THAT REDUCE Gs? ACTIVITY58 Genetic Defects in Vitamin D Metabolism and Action59 Hereditary Disorders of the Skeleton60 Osteoporosis61 CKD-MBD Syndrome: Chronic Kidney Disease Produced Disorders in Skeletal, Vascular, and Cardiac Tissues and Mineral Metabolism62 Disorders of Mineralization63 Paget's Disease of Bone64 Anatomy and Development of the Thyroid65 Thyroid-Stimulating Hormone and TSH Receptor66 Thyroid Hormone Transporters and Metabolism67 Thyroid Hormone Action68 Thyroid Function Testing (TSH, T3, and T4)69 Thyroid Imaging70 Pathology of the Thyroid Gland71 Graves' Disease72 Graves’ Orbitopathy73 Thyroiditis74 Hypothyroidism75 Thyroid and Pregnancy76 Iodine Nutrition and the Thyroid77 Euthyroid and hyperthyroid nodules and goiter78 Differentiated Thyroid Cancer - Streamlining Diagnosis And Optimizing Management79 Medullary Thyroid Cancer80 Anaplastic (Undifferentiated) Thyroid Carcinoma81 RESISTANCE TO THYROID HORMONE & GENETIC DEFECTS OF THE THYROID82 Surgical Management of Thyroid Disease83 Nonthyroidal Illness Syndrome84 Drugs that Affect Thyroid Function85 Adrenal development and Homeostasis86 Genetic Disorders of the Adrenal Cortex87 The Principles, Enzymes, and Pathways of Human Steroidogenesis88 Mineralocorticoids: Physiology, metabolism, receptors and resistance89 Glucocorticoid Receptors: Mechanisms of Action in Health and Disease90 Adrenal Androgens Adrenarche and Adrenopause91 Adrenal Pathology92 Adrenal Gland Imaging93 Adrenal Insufficiency94 Defects of Adrenal Steroidogenesis95 Adrenal Genomics II: Familial and sporadic neoplasia96 Primary Aldosteronism97 Adrenal Cushing’s Syndrome98 Adrenocortical Carcinoma99 Pheochromocytoma100 Adrenal Surgery101 Hypothalamic Regulation of GnRH101 Differences of Sex Development102 Endocrinology of Sexual Maturation and Puberty103 Endocrinology of Pubertal DisordersTBD104 Transgender Health Care105 Gonadotropin regulation, Androgen and estrogen physiology106 Hypogonadism - Pathogenesis, Diagnosis and Treatment107 Testosterone Deficiency: Aging and Chronic Disease108 Gynecomastia109 Erectile dysfunction110 Misuse and Abuse of Anabolic Hormones111 Regulation of Spermatogenesis112 Clinical Management of Male Infertility113 Male Contraception114 Testicular Dysgenesis Syndrome and Testicular Tumors115 Prevalence and Causes of Male Infertility116 Benign Prostatic Hyperplasia and Prostate Cancer117 The Menstrual Cycle and Disorders of Ovulation118 Prostate Cancer118 Folliculogenesis, Ovulation, and Luteogenesis119 Ovarian Hormone Synthesis120 Estrogen and Progesterone Action121 Prostate BPH and Prostate Cancer121 Contraception122 Menopause and Perimenopause123 Female Infertility: Evaluation and Management124 Androgen Excess Disorders in Women125 ENDOMETRIOSIS126 Uterine Fibroids and Adenomyosis.127 Hormonal Control of Breast Development128 Sexual Dysfunction in the Female129 Hormonal Control of Human Pregnancy and Parturition130 Fetal and Neonatal Endocrinology131 Hormonal Changes and Pregnancy Testing132 Autoimmune Polyglandular Syndromes133 Multiple Endocrine Neoplasia Type 1134 Multiple Endocrine Neoplasia Types 2 and 3, and Medullary Thyroid Carcinoma135 Neuroendocrine Tumor Syndromes136 Ectopic Hormone Syndromes137 Endocrine-Disrupting Chemicals and Human Health