Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging

Dr. Sandeep Kumar Singh is Assistant Professor in the All India Institute of Medical Sciences (AIIMS), Nagpur, India. He obtained his PhD in Biotechnology from Banaras Hindu University and conducted postdoctoral research in the Department of Neurobiology at the University of Chicago. Dr. Singh brings 17 years of experience in neuroscience, molecular biology, neurodegenerative diseases, aging, nutraceuticals, and nanomedicines. He is a member of several scientific societies, including the American Academy of Neurology, International Society of Neurochemistry, Society of Neurochemistry, Indian Academy of Neurosciences, and Alzheimer’s and related Disorders Society of India. Dr. Singh has published five books, including Elsevier’s A New Era in Alzheimer’s Research and Genome Editing for Neurodegenerative Diseases.Chih-Li Lin is a Professor and Research Fellow of Chung Shan Medical University and Hospital, Taiwan. He obtained his Ph. D. degree in the Institute of Biochemistry and Molecular Biology from National Taiwan University Medical College in 2007. Lin completed his postdoctoral research on the dementia & Alzheimer’s disease in National Taiwan University Hospital, and then moved to Institute of Medicine, Chung Shan Medical University (Taiwan) in 2008 and has been promoted to Full Professor in 2019. His major interests are to understand the pathophysiological connections between brain aging and Alzheimer’s dementia, particularly studying molecular mechanisms of amyloid beta (Aβ)-induced neurotoxicity, and applications of induced pluripotent stem (iPS) cell technology. He is currently working to demonstrate that brain insulin resistance may play roles in neuronal aging features and contribute to pathogenesis of Alzheimer's disease, Dementia with Lewy Bodies (DLB), and type 2 diabetes-associated dementia. Shailendra Kumar Mishra is co-founder of Indian Scientific Education and Technology (ISET) Foundation, a non-profit/non-governmental organization that persuades toward the science promotion. He is Molecular Human Genetics postgraduate, skilled in DNA Sequencing, Polymerase Chain Reaction (PCR), DNA & Plasmid isolation, Gel electrophoresis, Molecular hybridization, DNA elution from agarose gel, bacterial transformation, quantitation of DNA, DNA sequencing technique and versed in various diagnostic techniques. He did Master of Science in Molecular and Human Genetics from Jiwaji University, India, and research project from Banaras Hindu University, India. He has published his articles in some international and national journals such as Journal of Alzheimer’s Disease and Parkinsonism and Nature India. His major interest is to understand the aging process through molecular basis that could be beneficial to cure age-related diseases.

"This is a highly useful book that describes the modern theories of the aging process and its impact at a cellular and organ level. The book provides comprehensive discussion on the different hallmarks of aging and the strategies of anti-aging drug development with a focus on recent advances that slow or reverse the aging process including telomerase reactivation, clearance of senescent cells, and stem cell-based therapy among others…. The book meets the objectives as it provides valuable information on anti-aging drug discovery on the basis of the hallmarks of aging…. [It] has several high-quality colored illustrations, which make the subject matter easy to understand and more enjoyable.... This is an excellent book that discusses the modern theories of aging, the different hallmarks of aging, and the various anti-aging strategies…. I am quite hopeful this book will be of great value in supporting the multidisciplinary efforts to understand the aging process…. [A] unique [book] that addresses the hallmarks of aging on which anti-aging drug discovery is based." -- ©Doody’s Review Service, 2022, Omer Iqbal, MD, FACC, FESC (Loyola University Medical Center)

• 1. The aging: introduction, theories, principles and future prospectiveShabnam Shabir, Mahendra Pratap Singh2. Brief description of aging in different levels as cellular, tissues, and organsAnuradha Venkatakrishnan Chimata, Prajakta Deshpande, Amit Singh3. Brief about hallmarks of agingJosephine Esposto and Vyshnavy Balendra4. Overview of various anti-aging strategiesDhiraj Kumar and Faiyaz Ahmad5. Elimination of damaged cells-dependent anti-aging strategyRayees Ahmad Naik, Vinodinee Dubey, Roshni Rajpoot, Debabrata Dash, Nidhi Gupta and Raj Kumar Koiri6. Telomerase reactivation for anti-agingTS Gopenath, Shreya Shreshtha and Kanthesh M. Basalingapa7. Epigenetic drugs based on anti-aging approachTarun Minocha, Namrata Dwivedi, Chetan Panda, Anamika Misra, Barsha Baisakhi Nayak, Sanjeev Kumar Yadav, Hareram Birla and Sandeep K. Singh8. Activation of chaperons and proteolytic system: emerging methods for anti-aging drug developmentNeha Gogia, Victor Olmos, Fatema Haidery, Kimberly Luttik, Leon Tejwani, Janghoo Lim 9. Dietary restriction and mTOR and IIS inhibition: the potential to anti-aging drug approachSing-Hua Tsou10. Anti-Aging Drugs, Candidates, and Food Supplements- The journey so farYodhaanjali JR, Rithwick Surya, Sumukha KC, Harini G, Gouri Deshpande, Chandan S,Raghu Ram Achar11. Role of AMPK and Sirtuins as anti-aging proteinsManjula Ramu, Sonali Vishal and Neha Gogia12. Mitophagy and Mitohormetics: promising anti- aging strategyChih Li Lin13. Clearance of senescent cells: potent anti-aging approachJacques Ferreira and Alex Deamer14. Stem cell-based therapy as antiaging prospectiveSumaira Yusuf, Mahendra P. Singh15. Anti-inflammatory therapy as a game changer towards anti-agingDr. Naveen Shivavedi, Anshul Shakya, Bedanta Bhattacharjee and Bhargab Deka16. Invertebrate model organisms for aging researchArvind Kumar Shukla, Andrew Scott and Edward Giniger