Sandeep Kumar Singh – författare

Reverse Aging: Current Research and Future Directions explores the integrated approach of aging and reverse aging to present a comprehensive understanding of the biological, genetic, and molecular mechanisms associated with aging. By targeting fundamental aging mechanisms, strategies are being developed to reverse and repair damage and potentially lead to greater healthspan benefits and optimal longevity. The book opens with the fundamentals of aging and how genetic, environmental, and lifestyle variables affect the biological, psychological, and social processes that lead to aging before delving into a comprehensive review of the hallmarks of aging. Next, an overview of the concept of reverse aging is presented, and subsequent chapters examine specific reverse aging models and approaches. The book explores use of cellular reprogramming techniques, provides an overview of the molecular processes that underlie NANOG-mediated reversal aging, and discusses the possible contribution of IGF-1/PKA signaling reduction to reverse aging via HSC-based therapies. The developing science of rejuvenating stems cells, histone modification, and stimulation of autophagic activity to facilitate the removal of cellular debris and reduce the impact of aging on various organ systems as well as novel concepts of mRNA enhanced cell therapy, immunological-driven signaling, mitochondrial modulations, cell-cycle regulation, and metabolic reprogramming for reserve aging are all examined. The wide range of nutritional therapies, phytochemical, prescription medications, and nutraceuticals impacting the aging process is reviewed, and the book closes with discussion of the revolutionary role AI has on anti-aging research and where the field is headed. In conclusion, the book emphasizes the importance of targeting fundamental aging mechanisms to extend health and achieve optimal longevity and provides insights into the potential implications for healthcare and aging research, highlighting the need for collaborative efforts and interdisciplinary perspectives to address the challenges of population aging and develop effective strategies for healthy aging practices.Provides a multifaceted view of the latest scientific research on aging and reverse aging conceptsDescribes cellular and molecular mechanisms associated with the aging processExplores rejuvenation and aging reversal advances aimed at addressing the challenges of the aging populationPromotes aging knowledge to support informed healthcare decisions about health and longevity

Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed. Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals. Covers different aspects of anti-aging research, from foundational knowledge to future perspectives Provides understanding on the different hallmarks of aging and how they can be applied in the development of anti-aging drugs Discusses various anti-aging strategies, including telomerase reactivation, clearance of senescent cells, stem cell-based therapy, and others

Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed. Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals.- Covers different aspects of anti-aging research, from foundational knowledge to future perspectives- Provides understanding on the different hallmarks of aging and how they can be applied in the development of anti-aging drugs- Discusses various anti-aging strategies, including telomerase reactivation, clearance of senescent cells, stem cell-based therapy, and others

A New Era in Alzheimer''s Research: Pathogenesis, Prevention, and Treatment is focused on the research and perspectives in Alzheimer''s disease (AD), offering an update on the challenging aspects of neurodegenerative disorders. Each chapter of this book contains unique and valuable scientific information on the latest progress of research in neurodevelopmental diseases. Even after years of research, Alzheimer''s disease is still far from being cured; this book addresses the most current issues within the many dimensions relevant to the pathogenesis, diagnosis, and prevention under one cover, making it useful for researchers, students, and clinicians, as well as those in pharmaceuticals.- Contains basic knowledge about Alzheimer''s disease and its causes and related pathology for a better understating of AD- Provides the multidisciplinary research on Alzheimer''s disease in one source- Uniquely describes the details of the pathological, diagnostic, and preventive information for the potential development of novel anti-AD drugs- Includes hot topics, such as cerebrovascular pathology and lifestyle medicine, for the prevention of AD

A New Era in Alzheimer's Research: Pathogenesis, Prevention, and Treatment is focused on the research and perspectives in Alzheimer's disease (AD), offering an update on the challenging aspects of neurodegenerative disorders. Each chapter of this book contains unique and valuable scientific information on the latest progress of research in neurodevelopmental diseases. Even after years of research, Alzheimer's disease is still far from being cured; this book addresses the most current issues within the many dimensions relevant to the pathogenesis, diagnosis, and prevention under one cover, making it useful for researchers, students, and clinicians, as well as those in pharmaceuticals.Contains basic knowledge about Alzheimer’s disease and its causes and related pathology for a better understating of ADProvides the multidisciplinary research on Alzheimer’s disease in one sourceUniquely describes the details of the pathological, diagnostic, and preventive information for the potential development of novel anti-AD drugsIncludes hot topics, such as cerebrovascular pathology and lifestyle medicine, for the prevention of AD

Protein Misfolding in Neurodegenerative Diseases is a comprehensive review of proteome homeostasis in neurons, and in the brain. Beginning with an introduction on factors involved in the formation and aggregation of misfolded proteins, chapters then discuss the precise cellular and molecular mechanisms involved in these processes and their role in neurodegeneration and disease. Additional topics of focus include protein clearance mechanisms like protein quality control, disease-modifiers, molecular druggable targets, novel therapeutics, and emerging techniques that block or delay disease onset or progression. This volume is relevant for researchers working with neurodegenerative diseases, including Alzheimer's disease, Parkinson’s disease, ALS, Creutzfeldt-Jakob disease, and more.

Discusses underlying cellular and molecular mechanisms altered in protein-associated neurodegenerative disordersDescribes methods for detection and analysis of protein aggregatesFeatures advancements in therapeutics and emerging techniques to treat these disordersCovers implications in a variety of neurodegenerative diseases, including Alzheimer's, Parkinson’s, ALS, Creutzfeldt-Jakob disease, Cystic fibrosis, Gaucher's disease, and Polyglutamine diseases, including Huntington’s and other related proteinopathies

Approx.280 pages- Discusses underlying cellular and molecular mechanisms altered in protein-associated neurodegenerative disorders- Describes methods for detection and analysis of protein aggregates- Features advancements in therapeutics and emerging techniques to treat these disorders- Covers implications in a variety of neurodegenerative diseases, including Alzheimer''s, Parkinson''s, ALS, Creutzfeldt-Jakob disease, Cystic fibrosis, Gaucher''s disease, and Polyglutamine diseases, including Huntington''s and other related proteinopathies

Genome Editing for Neurodegenerative Diseases: From Concept to Clinical Trials examines recent advances in neurodegenerative disease research and clinical challenges in practical applications. With an emphasis on genome editing tools such as ZFNs, TALENSs and CRISPR-Cas, this book sheds light on the possibilities to counteract genetic and neurodegenerative diseases. It will be of interest to researchers in neuroscience and biopharmaceuticals, as well as clinicians specializing in neurodegenerative diseases.

Covers basic mechanisms of genome-editing tools and their therapeutic potential

Highlights current research progress and the therapeutic strategies to use genome-editing tools against neurodegenerative diseases

Includes research on genome-editing tool development from the basic concept to clinical trials

Genome Editing for Neurodegenerative Diseases: From Concept to Clinical Trials examines recent advances in neurodegenerative disease research and clinical challenges in practical applications. With an emphasis on genome editing tools such as ZFNs, TALENSs and CRISPR-Cas, this book sheds light on the possibilities to counteract genetic and neurodegenerative diseases. It will be of interest to researchers in neuroscience and biopharmaceuticals, as well as clinicians specializing in neurodegenerative diseases.- Covers basic mechanisms of genome-editing tools and their therapeutic potential- Highlights current research progress and therapeutic strategies to use genome-editing tools against neurodegenerative diseases- Includes research on genome-editing tool development, from basic concept to clinical trials

Biology of Aging Accelerators: Fundamentals, Hallmarks and Therapeutic Interventions explores how biological, genetic, and environmental factors affect cellular and systemic homeostasis and lead to accelerated aging. The book begins with a historical perspectives, highlighting the growth in immune system deterioration, chronic illness, and social issues. It then examines the hallmarks of aging, including primary, antagonistic, and integrative characteristics that may or may not be contributors. Subsequent chapters explore basic concepts and key accelerators in human biology, the role of biological clocks, and mechanisms of aging accelerators such as cellular senescence, DNA damage, and mitochondrial dysfunction.The book also addresses how different organs age at different rates and the brain's role as the body's aging integrator and provides actionable insights into innovative therapies aimed at reducing or stopping the signs and symptoms of aging, including developments in medications, lifestyle adjustments, regenerative medicine, and cutting-edge technologies like stem cell therapy and CRISPR. By integrating scientific research and practical insights, this book offers a realistic perspective on anti-aging research and stimulates novel ideas for improving quality of life.Offers an in-depth understanding of the biological, genetic, and environmental factors accelerating agingExplores cutting-edge treatments, including gene therapy, regenerative medicine, and nutraceuticalsIntegrates findings from genomics, epigenetics, and molecular biology for a holistic view of agingProvides actionable strategies to incorporate anti-aging interventions into practiceHighlights current research trends and future directions for reducing or preventing accelerated aging

The "Neurobiology of Type 2 Diabetes" delves into the intricate interplay between the nervous system and the development, progression, and management of Type 2 Diabetes. This comprehensive volume explores the often-overlooked neurological aspects of diabetes, offering a unique perspective on the disease. The purpose of this book is to bridge the gap between neuroscience and diabetes research, providing a consolidated resource that elucidates the complex relationship between the brain and metabolic regulation. By synthesizing the latest scientific findings, the book aims to offer researchers, clinicians, and students a deep understanding of how neural pathways influence glucose homeostasis, insulin sensitivity, and the emergence of diabetic complications.. Discusses the neurobiology of glucose homeostasis and insulin resistance . Includes neural circuits and neuroendocrine regulation . Identifies clinical manifestations, diagnostic tools, and management for diabetic neuropathy . Provides case studies for examples of cases and clinical decisions with outcomes . Reviews emerging therapeutics for Type 2 diabetes

The "e;Neurobiology of Type 2 Diabetes"e; delves into the intricate interplay between the nervous system and the development, progression, and management of Type 2 Diabetes. This comprehensive volume explores the often-overlooked neurological aspects of diabetes, offering a unique perspective on the disease. The purpose of this book is to bridge the gap between neuroscience and diabetes research, providing a consolidated resource that elucidates the complex relationship between the brain and metabolic regulation. By synthesizing the latest scientific findings, the book aims to offer researchers, clinicians, and students a deep understanding of how neural pathways influence glucose homeostasis, insulin sensitivity, and the emergence of diabetic complications.* Discusses the neurobiology of glucose homeostasis and insulin resistance * Includes neural circuits and neuroendocrine regulation * Identifies clinical manifestations, diagnostic tools, and management for diabetic neuropathy * Provides case studies for examples of cases and clinical decisions with outcomes * Reviews emerging therapeutics for Type 2 diabetes

Reverse Aging: Current Research and Future Directions explores the integrated approach of aging and reverse aging to present a comprehensive understanding of the biological, genetic, and molecular mechanisms associated with aging. By targeting fundamental aging mechanisms, strategies are being developed to reverse and repair damage and potentially lead to greater healthspan benefits and optimal longevity. The book opens with the fundamentals of aging and how genetic, environmental, and lifestyle variables affect the biological, psychological, and social processes that lead to aging before delving into a comprehensive review of the hallmarks of aging. Next, an overview of the concept of reverse aging is presented, and subsequent chapters examine specific reverse aging models and approaches. The book explores use of cellular reprogramming techniques, provides an overview of the molecular processes that underlie NANOG-mediated reversal aging, and discusses the possible contribution of IGF-1/PKA signaling reduction to reverse aging via HSC-based therapies. The developing science of rejuvenating stems cells, histone modification, and stimulation of autophagic activity to facilitate the removal of cellular debris and reduce the impact of aging on various organ systems as well as novel concepts of mRNA enhanced cell therapy, immunological-driven signaling, mitochondrial modulations, cell-cycle regulation, and metabolic reprogramming for reserve aging are all examined. The wide range of nutritional therapies, phytochemical, prescription medications, and nutraceuticals impacting the aging process is reviewed, and the book closes with discussion of the revolutionary role AI has on anti-aging research and where the field is headed. In conclusion, the book emphasizes the importance of targeting fundamental aging mechanisms to extend health and achieve optimal longevity and provides insights into the potential implications for healthcare and aging research, highlighting the need for collaborative efforts and interdisciplinary perspectives to address the challenges of population aging and develop effective strategies for healthy aging practices. - Provides a multifaceted view of the latest scientific research on aging and reverse aging concepts- Describes cellular and molecular mechanisms associated with the aging process- Explores rejuvenation and aging reversal advances aimed at addressing the challenges of the aging population- Promotes aging knowledge to support informed healthcare decisions about health and longevity

Epigenetic Therapy by Phytochemicals in Lung Cancer provides a comprehensive exploration of the intersection between cancer epigenetics and phytotherapy, focusing on lung cancer. The book emphasizes the role of epigenetic alterations in cancer progression and presents phytochemicals as promising agents capable of reversing these changes, thereby offering innovative therapeutic strategies. The content examines the mechanisms by which epigenetic modifications, such as DNA methylation and histone modification, contribute to lung cancer. It details specific phytochemicals-like curcumin, resveratrol, and quercetin-and their potential to modulate these pathways, while discussing clinical applications, challenges, and future research directions. For academics, this book equips researchers and healthcare professionals with evidence-based insights into alternative cancer therapies, enhancing understanding of multi-targeted approaches. It serves as a valuable reference for teaching and further research, promoting a more inclusive perspective in cancer care and addressing disparities in treatment access and efficacy.Collates current research on epigenetic changes in lung cancer and how specific phytochemicals interact with these mechanisms to halt or reverse tumor progressionDiscusses the therapeutic potential of phytochemicals as low-toxicity alternatives or adjuncts to conventional lung cancer treatmentsIdentifies gaps in current research and outlines promising areas for study, helping researchers and practitioners pinpoint future opportunities in developing effective phytochemical-based therapies

Epigenetic Therapy by Phytochemicals in Lung Cancer provides a comprehensive exploration of the intersection between cancer epigenetics and phytotherapy, focusing on lung cancer. The book emphasizes the role of epigenetic alterations in cancer progression and presents phytochemicals as promising agents capable of reversing these changes, thereby offering innovative therapeutic strategies. The content examines the mechanisms by which epigenetic modifications, such as DNA methylation and histone modification, contribute to lung cancer. It details specific phytochemicals-like curcumin, resveratrol, and quercetin-and their potential to modulate these pathways, while discussing clinical applications, challenges, and future research directions. For academics, this book equips researchers and healthcare professionals with evidence-based insights into alternative cancer therapies, enhancing understanding of multi-targeted approaches. It serves as a valuable reference for teaching and further research, promoting a more inclusive perspective in cancer care and addressing disparities in treatment access and efficacy. - Collates current research on epigenetic changes in lung cancer and how specific phytochemicals interact with these mechanisms to halt or reverse tumor progression- Discusses the therapeutic potential of phytochemicals as low-toxicity alternatives or adjuncts to conventional lung cancer treatments- Identifies gaps in current research and outlines promising areas for study, helping researchers and practitioners pinpoint future opportunities in developing effective phytochemical-based therapies

Sustainable agriculture is at a critical crossroads as global food demand rises alongside challenges such as soil degradation, climate change, and declining resource efficiency. Sustainable Agri-Productivity: A Roadmap to Hunger Alleviation using Beneficial Microbes addresses these pressing concerns by presenting microbes as key drivers of resilient and productive agroecosystems. This book aims to bridge the gap between fundamental microbial science and its practical applications in agriculture.This volume stands out by offering a holistic and multidisciplinary approach, integrating crop productivity, soil health management, and emerging biotechnological innovations. It provides insights into how beneficial microbes can enhance nutrient availability, improve stress tolerance, and restore ecological balance across diverse farming systems, including stress-prone environments such as saline and arid regions.Key Features: Role of beneficial microbes in major crops including cereals, legumes, and horticultural systems Microbial approaches for improving soil fertility and nutrient cycling Strategies for managing saline, arid, and water-limited agricultural conditions Advances in plant microbiome research and microbial biotechnology Application of precision agriculture and genome-based microbial interventions Development and use of biofertilizers and sustainable input systems Overall, this book serves as a comprehensive resource for researchers, academicians, policymakers, and students in agriculture and allied sciences. It is also valuable for extension professionals and practitioners seeking sustainable, microbe-based solutions for enhancing productivity and ensuring global food security.

Sustainable agriculture is at a critical crossroads as global food demand rises alongside challenges such as soil degradation, climate change, and declining resource efficiency. Sustainable Agri-Productivity: A Roadmap to Hunger Alleviation using Beneficial Microbes addresses these pressing concerns by presenting microbes as key drivers of resilient and productive agroecosystems. This book aims to bridge the gap between fundamental microbial science and its practical applications in agriculture.This volume stands out by offering a holistic and multidisciplinary approach, integrating crop productivity, soil health management, and emerging biotechnological innovations. It provides insights into how beneficial microbes can enhance nutrient availability, improve stress tolerance, and restore ecological balance across diverse farming systems, including stress-prone environments such as saline and arid regions.Key Features:Role of beneficial microbes in major crops including cereals, legumes, and horticultural systemsMicrobial approaches for improving soil fertility and nutrient cyclingStrategies for managing saline, arid, and water-limited agricultural conditionsAdvances in plant microbiome research and microbial biotechnologyApplication of precision agriculture and genome-based microbial interventionsDevelopment and use of biofertilizers and sustainable input systemsOverall, this book serves as a comprehensive resource for researchers, academicians, policymakers, and students in agriculture and allied sciences. It is also valuable for extension professionals and practitioners seeking sustainable, microbe-based solutions for enhancing productivity and ensuring global food security.

Social work plays a pivotal role in promoting human development and addressing social inequalities. This book examines the interplay between social work practices and developmental theories across the lifespan. Topics include child welfare, aging, mental health, and community development. Case studies highlight innovative approaches to empowering vulnerable populations and fostering social change. The book emphasizes ethical considerations and culturally sensitive practices. It is a valuable resource for students and professionals in social work, sociology, and public health.

This book aims to provide a comprehensive understanding of the multi-scale mechanics of high entropy alloys (HEAs). High entropy alloys are an emerging class of materials with unique structural and mechanical properties, attributed to their core effects such as high configurational entropy, sluggish diffusion, lattice distortion, and cocktail effects. The initial chapters introduce the fundamentals of HEAs, including synthesis routes, phase stability, and microstructural features. Special emphasis is placed on computational approaches, where molecular dynamics (MD) simulations and machine learning (ML)-assisted modelling are employed to predict thermodynamic, kinetic, and mechanical responses of HEAs at different length and time scales. Subsequent chapters explore the mechanical behaviour of HEAs under various deformation regimes and environmental conditions. The later chapters connect computational results with experimental observations, presenting case studies where simulations and ML models guide the interpretation of material performance. Challenges associated with large-7scale synthesis, property validation, and transferability of computational models to real-world applications are also discussed, along with future research directions. This book is intended to serve as a critical resource for researchers, engineers, and graduate students working in the field of materials science and engineering.

This book aims to provide a comprehensive understanding of the multi-scale mechanics of high entropy alloys (HEAs). High entropy alloys are an emerging class of materials with unique structural and mechanical properties, attributed to their core effects such as high configurational entropy, sluggish diffusion, lattice distortion, and cocktail effects. The initial chapters introduce the fundamentals of HEAs, including synthesis routes, phase stability, and microstructural features. Special emphasis is placed on computational approaches, where molecular dynamics (MD) simulations and machine learning (ML)-assisted modelling are employed to predict thermodynamic, kinetic, and mechanical responses of HEAs at different length and time scales. Subsequent chapters explore the mechanical behaviour of HEAs under various deformation regimes and environmental conditions. The later chapters connect computational results with experimental observations, presenting case studies where simulations and ML models guide the interpretation of material performance. Challenges associated with large-7scale synthesis, property validation, and transferability of computational models to real-world applications are also discussed, along with future research directions. This book is intended to serve as a critical resource for researchers, engineers, and graduate students working in the field of materials science and engineering.