Häftad, Engelska, 2025
Protein Misfolding in Neurodegenerative Diseases
Av Neha Gogia, Sandeep Kumar Singh, Vidyadhara Devarunda Jaganath
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Beskrivning
Protein Misfolding in Neurodegenerative Diseases is a comprehensive review of proteome homeostasis in neurons, and in the brain. Beginning with an introduction on factors involved in the formation and aggregation of misfolded proteins, chapters then discuss the precise cellular and molecular mechanisms involved in these processes and their role in neurodegeneration and disease. Additional topics of focus include protein clearance mechanisms like protein quality control, disease-modifiers, molecular druggable targets, novel therapeutics, and emerging techniques that block or delay disease onset or progression. This volume is relevant for researchers working with neurodegenerative diseases, including Alzheimer's disease, Parkinson’s disease, ALS, Creutzfeldt-Jakob disease, and more.
- Discusses underlying cellular and molecular mechanisms altered in protein-associated neurodegenerative disorders
- Describes methods for detection and analysis of protein aggregates
- Features advancements in therapeutics and emerging techniques to treat these disorders
- Covers implications in a variety of neurodegenerative diseases, including Alzheimer's, Parkinson’s, ALS, Creutzfeldt-Jakob disease, Cystic fibrosis, Gaucher's disease, and Polyglutamine diseases, including Huntington’s and other related proteinopathies
Produktinformation
- Utgivningsdatum: 2025-03-20
- Mått: 152 x 229 x 30 mm
- Vikt: 900 g
- Format: Häftad
- Språk: Engelska
- Antal sidor: 574
- Förlag: Elsevier Science
- ISBN: 9780443187162
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Mer om författaren
Dr. Gogia is a Post-Doctoral Associate at Yale. Having completed her PhD degree at the University of Dayton, and Cornell University’s International Agriculture and Rural Development Program (IARD) she was awarded the Gerald L. Willis Award of Excellence for Outstanding Teaching in 2019. Her current work focuses on understanding cellular and molecular mechanisms underlying polyglutamine diseases, namely the identification and validation of genetic modifiers which can serve as potential therapeutic targets and can ameliorate the onset or progression of neurodegenerative diseases. Dr. Sandeep Kumar Singh is Assistant Professor in the All India Institute of Medical Sciences (AIIMS), Nagpur, India. He obtained his PhD in Biotechnology from Banaras Hindu University and conducted postdoctoral research in the Department of Neurobiology at the University of Chicago. Dr. Singh brings 17 years of experience in neuroscience, molecular biology, neurodegenerative diseases, aging, nutraceuticals, and nanomedicines. He is a member of several scientific societies, including the American Academy of Neurology, International Society of Neurochemistry, Society of Neurochemistry, Indian Academy of Neurosciences, and Alzheimer’s and related Disorders Society of India. Dr. Singh has published five books, including Elsevier’s A New Era in Alzheimer’s Research and Genome Editing for Neurodegenerative Diseases.Vidyadhara Devarunda Jaganath works in the Department of Neurology and Neuroscience, Yale University School of Medicine, CT, USA.
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