Human Reproductive and Prenatal Genetics

Dr. Leung is a Professor at the University of British Columbia’s Department of Obstetrics & Gynecology and former Associate Dean in the Faculty of Medicine at UBC. Dr. Leung received his PhD from Western University. After post-doctoral training at the University of California at Los Angeles and the Laval University, he joined the University of British Columbia in 1982 as a faculty member. Dr. Leung has received a number of prestigious awards, including a Scholar Award and a Scientist Award from the Medical Research Council of Canada, a Distinguished Scholar Award from the Michael Smith Foundation for Health Research and a Senior Scientist Award from the BC Children Hospital Research Institute. Dr. Leung has served on many national and international organizations, including as President of the Canadian Fertility and Andrology Society, Director of the Society for the Study of Reproduction, Director of the Ovarian Workshops in the USA, temporary advisor to the World Health Organization, Fellow of the Canadian Academy for Health Sciences, and Fellow of the Royal Society of Canada. Dr. Leung’s research focuses on hormonal determinants of women’s reproductive health. His publication record to date includes 400 papers, 350 abstracts, 22 book chapters and 7 monographs. Since his appointment at UBC, Dr. Leung has served as the research supervisor for more than 100 graduate students, postdoctoral fellows and visiting scientists. Dr. Jie Qiao is the Chief Scientist of the Ministry of Science and Technology of China, the Incumbent Director of the North Third Hospital Department of Obstetrics and Gynecology, the Chinese Medical Association branch chairman for Reproductive Medicine, and the Beijing Medical Association branch chairman for Reproductive Medicine. She has been engaged in reproductive health-related clinical and basic research throughout her career, including as a visiting scholar at the University of Hong Kong and as a post-doctoral researcher at Stanford University. Her research has focused on gametes fertilization, infertility and embryo implantation mechanisms, and polycystic ovary syndrome pathogenesis among other topics. Dr. Jie Qiao has published more than 250 paper publications in peer reviewed journals on topics related to reproductive health.

*4 stars* "…a comprehensive overview of human reproductive and prenatal genetics…. with a substantial amount of new information, particularly concerning new genetic, epigenetic, and "omic" methods...[and] a focus on infertility and difficulties in successful pregnancy outcomes. New genetic and genomic technologies have aided the resolution of reproductive difficulties, and this volume describes the relevance of these methods in reproductive medicine…. [W]ritten for clinicians and researchers working in the field of human reproduction and those studying infertility and adverse pregnancy outcomes…. The authors have assembled an international group of more than 125 expert contributors in human reproduction to produce this new edition…[which] goes a long way toward disseminating the newest tools and techniques for assisting reproduction and advancing the goal of successful pregnancy outcomes. This second edition is a welcome update." --©Doody’s Review Service, 2023, Mark F. Sanders, PhD (UC Davis College of Biological Sciences)

• Section I: Reproductive tract development and gametogenesis1. Developmental genetics of the male reproductive systemMarisol O’Neill, Victor A. Ruthig, Meade Haller, Boryana Zhelyazkova, Jeffrey T. White, Nannan Thirumavalavan, and Dolores J. Lamb2. Developmental genetics of the female reproductive tractJessica Garcia de Paredes, Michael Strug, Jordan Gosnell, Marcos Cordoba, and Jose M. Teixeira3. Genetics and genomics of early gonad developmentFanghong Ou, Zhangting Wang, Jinyue Liao, Hoi-Ching Suen, Kai Kei Miu, and Wai-Yee Chan4. Effects of aging on sperm chromatinHeather E. Fice and Bernard Robaire5. In vitro spermatogenesis from pluripotent stem cellsJin Du, Qing-Qin Gao, Cheng Huang, Hai-Ping Jiang, Mo-Yu Dai, Yu-Fei Li, Jun Wu, and Qi Zhou6. The molecular genetics of oogenesisFan Zhai, Xinyi Ma, Liying Yan, and Jie Qiao7. Growth of the mammalian oocyte: Focus on intercellular contact and communicationHugh J. Clarke8. In vitro activation of ovarian folliclesKazuhiro KawamuraSection II: Embryo implantation, placenta development and pregnancy9. Interaction of sperm and embryo with the female reproductive tractYin Lau Lee, Andy Chun Hang Chen, and William Shu Biu Yeung10. MicroRNAs in gametes and preimplantation embryos: Clinical implicationsAllison Tscherner, Nicholas Werry, Leanne Stalker, and Jonathan LaMarre11. Epigenetic modifications in the human placentaWendy P. Robinson, Maria S. Pen˜ aherrera, Chaini Konwar, Victor Yuan, and Samantha L. Wilson12. In vitro models of human blastocysts and early embryogenesisJia Ping Tan, Xiaodong Liu, and Jose M. Polo13. microRNAs in pregnancy: Implications for basic research and clinical managementPeng Xu, Xuan Shao, Ming Liu, and Yan-Ling Wang14. Human X-chromosome inactivation: Complexity and clinical implicationsMaria Jose Navarro-Cobos, Karanveer Bhangu, and Carolyn J. Brown15. The intergenerational effects on fetal programmingHe-Feng Huang, Guo-Lian Ding, Xin-Yuan Li, Xin-Mei Liu, and Zi-Ru JiangSection III: Infertility and assisted reproductive technology16. Theoretical and experimental strategies for preservation and restoration of male fertilityAli Honaramooz17. Update on the genetics and genomics of premature ovarian insufficiencyElena J. Tucker, Sylvie Jaillard, and Andrew H. Sinclair18. Premature ovarian insufficiencyYingying Qin, Ting Guo, Shidou Zhao, and Zi-Jiang Chen19. Genetics of polycystic ovary syndromeTristan Hardy, Alice P. Rogers, and Robert J. Norman20. Developmental origins and genetic basis of polycystic ovary syndromeT.M. Barber and S. Franks21. Genetic basis of metabolism and inflammation in PCOSYanli Pang, Yue Zhao, and Jie Qiao22. Genetics and genomics of recurrent pregnancy lossLaura Kasak, Kristiina Rull, and Maris Laan23. Genetics and genomics of endometriosisLinda C. Giudice, Richard O. Burney, Christian M. Becker, Stacey A. Missmer, Grant Montgomery, Nilufer Rahmioglu, Peter A.W. Rogers, and Krina Zondervan24. Human genetics and assisted reproduction in endometriosisYa-Ching Chou, Chien-Wen Chen, Endah Rahmawati, Guan-Lin Lai, Yun-Yi Ma, Yi-Xuan Lee, Ming-Jer Chen, and Chii-Ruey Tzeng25. Uterus transplantation as an infertility treatmentMats Brannstrom, Ali Khatibi, Ghada Hussein, and Pernilla Dahm-K€ahler26. Impacts of COVID-19 on reproductive health and prenatal geneticsPeng Yuan, Zhiqiang Yan, Wei Wang, Yao Li, Qilong He, Fan Zhai, Liying Yan, and Jie QiaoSection IV: Preimplantation/prenatal genetic diagnosis and screening27. Genomics in reproductive medicine: Current and future applicationsMaurizio Poli and Antonio Capalbo28. Molecular cytogenomics of human genetic disordersZirui Dong, Kwong Wai Choy, and Cynthia C. Morton29. Next-generation sequencing for gene panels, clinical exome, and whole-genome analysisMatthew A. Shanahan, Liesbeth Vossaert, and Ignatia B. Van den Veyver30. Chromosomal microarrays and next-generation sequencing for diagnosis of fetal abnormalitiesBrynn Levy, Melissa Stosic, Jessica Giordano, Ronald Wapner, and Vimla Aggarwal31. Noninvasive prenatal testing for genetic diseasesStephanie C.Y. Yu, Jason C.H. Tsang, and Y.M. Dennis Lo32. Noninvasive prenatal testing/screening by circulating cell-free DNAMargot van Riel, Kate Stanley, and Joris R. Vermeesch33. Application of new technologies in embryos: From gene editing to synthetic embryosM. Martin-Inaraja, I. Romayor, L. Herrera, N. Montserrat, and C. Eguizabal