Pharmacokinetics and Toxicokinetic Considerations - Vol II

Dr Rakesh K Tekade, Assistant Professor of the Department of Pharmaceutics, investigates the design, development and characterization of targeted nanotechnology based formulations for the site specific delivery of therapeutic drugs, siRNA, microRNA, plasmids, proteins and peptide for the treatment of cancer. His current research encompasses development of novel polymeric nanomaterial for effective cytosolic delivery of anticancer bioactives. Dr Tekade’s research is focused on designing a new generation of nanoparticles, which could identify the cancer cells and selectively deliver anticancer drugs and genes to inhibit the growth of cancer while sparing healthy tissues. His research work involves the applications of polymer chemistry, nanotechnology, molecular biology, pharmacokinetics/pharmacodynamics and imaging techniques. Dr Tekade has over 70 publications, 01 patent, 7 book chapters, and 3 editorial articles. He has delivered several invited research talks and presented research finding in more than 30 scientific conferences.

• 1. Basic principles and concept in Toxicokinetic2. Factors Influencing Drug Toxicity3. Molecular biology of apoptotic, necrotic and necroptotic cell death4. Toxicogenomic in drug safety assessment5. Understanding the concept of signal toxicity6. Importance of toxicity testing7. Methods and Models for in vitro toxicity8. New Emerging technologies for genetic toxicity testing9. Zebrafish models for toxicological screening10. Impact of ageing on the pharmacokinetics and pharmacodynamics of the drugs11. Food-Drug Interactions and their Implications on Oral Drug Bioavailability12. Drug-Drug interactions and their implications on the Pharmacokinetics of the Drugs13. Clinical Importance of Herb-Drug interaction14. Insilico methods for the prediction of drug toxicity15. Organ-on-a-chip for assessing environmental toxicants16. Toxicity and toxicokinetics consideration in product development and drug research17. Drug Toxicity and Forensic Pharmacokinetics 18. Excipient’s toxicity and safety19. Pharmaceutical excipients: Special focus on Adverse drug interactions20. Emerging role of novel excipients in drug product development and their safety concerns21. Toxicity of Pharmaceutical azo dyes22. Environmental and Safety Aspects of Bionanotechnology23. Toxicological Risk assessment of medical devices24. Developmental toxicity of nanomaterials used in healthcare25. Ethical defilements in clinical research and potential roles of Institutional review board26. Toxicodynamic in Drug research