Gerald M. Cohen Ph.D. is Head of the Toxicology Unit, Department of Pharmacology, The School of Pharmacy, University of London.

• 1. Basic Principles of Target Organ Toxicity 2. Role of Pharmacokinetics in Rationalizing Tissue Distribution 3. The Role of Metabolic Activation in Target Organ Toxicity 4. Role of Excretion 5. Species Variation in Target Organ Toxicity 6. The Importance of Tissue-Specific Biochemistry in the Determination of Target Organ Toxicity 7. Role of Key Defense Systems in Target Organ Toxicity 8. The Liver as a Target Organ for Toxicity 9. The Nervous System as a Target Organ for Toxicity

Gerald M. Cohen Ph.D. is Head of the Toxicology Unit, Department of Pharmacology, The School of Pharmacy, University of London.

• 1. Basic Principles of Target Organ Toxicity 2. Role of Pharmacokinetics in Rationalizing Tissue Distribution 3. The Role of Metabolic Activation in Target Organ Toxicity 4. Role of Excretion 5. Species Variation in Target Organ Toxicity 6. The Importance of Tissue-Specific Biochemistry in the Determination of Target Organ Toxicity 7. Role of Key Defense Systems in Target Organ Toxicity 8. The Liver as a Target Organ for Toxicity 9. The Nervous System as a Target Organ for Toxicity

Gerald M. Cohen Ph.D. is Head of the Toxicology Unit, Department of Pharmacology, The School of Pharmacy, University of London.

• 1. Basic Principles of Target Organ Toxicity 2. Role of Pharmacokinetics in Rationalizing Tissue Distribution 3. The Role of Metabolic Activation in Target Organ Toxicity 4. Role of Excretion 5. Species Variation in Target Organ Toxicity 6. The Importance of Tissue-Specific Biochemistry in the Determination of Target Organ Toxicity 7. Role of Key Defense Systems in Target Organ Toxicity 8. The Liver as a Target Organ for Toxicity 9. The Nervous System as a Target Organ for Toxicity