Neil Kaplowitz, Laurie D. DeLeve

• Part I: Mechanisms of Liver Injury 1. Drug-Induced Liver Disease 2. Cytochrome P450 Activation of Toxins and Hepatotoxicity 3. Antioxidant Defense in Liver Injury: Oxidant Stress, Antioxidant Defense, and Liver Injury 4. Hepatotoxicity Due to Mitochondrial Injury 5. Mechanisms of Cell Death and Relevance to Drug Hepatotoxicity 6. Significance of Hepatobiliary Transporters for Drug-Induced Liver Disease 7. Immunological Mechanisms in Drug-Induced Liver Injury 8. Mechanistic Role of Acyl Glucuronides 9. Nonparenchymal Cells, Inflammatory Macrophages, and Hepatotoxicity 10. Role of Tissue Repair in Liver Injury 11. Genetic Susceptibility to Drug-Induced Liver Disease Part II: Diagnosis and Management 12. Clinicopathological Patterns of Drug-Induced Liver Disease 13. Histopathology of Drug-Induced Liver Disease 14. Risk Factors for Drug-Induced Liver Disease 15. Genomics, Proteomics, and Metabolomics in the Diagnosis and Mechanisms of Drug-Induced Liver Disease 16. Causality Assessment 17. Management of the Patient with Drug-Induced Liver Disease Part III: Hepatotoxicity of Specific Drugs 18. Mechanisms of Acetaminophen-Induced Liver Disease 19. Acetaminophen: Pathology and Clinical Presentation of Hepatotoxicity 20. Mechanisms Underlying the Hepatotoxicity of Nonsteroidal Anti-inflammatory Drugs 21. Nonsteroidal Anti-inflammatory Drugs and Leukotriene Receptor Antagonists: Pathology and Clinical Presentation of Hepatotoxicity 22. Mechanism, Pathology, and Clinical Presentation of Hepatotoxicity of Anesthetic Agents 23. Anticonvulsant Agents 24. Hepatotoxicity of Psychotropic Drugs and Drugs of Abuse 25. Antibacterial and Antifungal Agents 26. Hepatotoxicity of Antituberculosis Drugs 27. Hepatic Toxicity of Antiviral Agents 28. Hepatotoxicity of Cardiovascular and Antidiabetic Medications 29. Cancer Chemotherapy 30. Hepatotoxicity of Immunomodulating Agents and the Transplant Situation 31. Methotrexate Controversies 32. Adverse Effects of Hormones and Hormone Antagonist