Richly Parameterized Linear Models

James S. Hodges

"Richly Parameterized Linear Models is a strong addition to the literature on mixed models, offering a much more unified treatment and broader scope than many existing texts. … The book also provides an excellent treatment of diagnostics for mixed models. … The literature on mixed models has expanded in recent decades, often in disparate ways. Richly Parameterized Linear Models provides a step toward unifying this growing area of research and serves as an excellent resource for applied researchers with experience and interest in mixed models."—Journal of the American Statistical Association, Vol. 110, 2015"This is a thought-provoking book that stimulates discussion and further research. … It is a refreshing idea to concentrate on poorly understood ‘mysteries’ in the class of linear mixed models. … If you have ever encountered similar issues in linear mixed models, you will appreciate this book. Furthermore, if you are looking for new scientific challenges, then you will find a large resource of still open questions and useful references. Graduate students will develop a deeper understanding of the linear mixed model and critical thinking in the application of this model class. … We recommend this book, as it will stimulate further research, leading to deeper insight into richly parametrized linear models."—Biometrical Journal, 2015"Hodges’ book is a really recommendable reference for mixed models users. Use of random effects models has exponentially grown during the last few decades mainly due to the availability of software making the fit of these models possible. Such software has made mixed models available to a wide community of users, thus complex analyses with complex covariance structures have filled both applied and theoretical journals. Nevertheless, as masterfully described within this book, the hypotheses underneath these models, and the corresponding covariance structures, are not harmless at all but, on the contrary, they may have a large impact on their fit. Hodges’ monograph explores and highlights the repercussion of many aspects involved in the definition of most mixed models that are usually unknown or, even worse, ignored. Hodges makes us aware of these issues that should be kept very in mind by any mixed models user and illustrates them with lots of real case studies.This is an extremely clarifying tool for those who usually work with GLMMs in general. Mathematical details underlying GLMMs are usually overwhelming … Hodges makes a journey to the grounds of linear mixed models, where mathematical detail is more accessible, providing a deep insight also of use in GLMMs. The approach described in this book yields some intuition about what can be happening underneath the complex GLMMs that are usually used in practice."—Miguel Martinez Beneito, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region"I recommend this text to any student/researcher who is interested in mixed models. The book is written in an enthralling and engaging style and is overflowing with interesting observations, has a unique spin, and is very thought provoking. Over the past 20 years there has been a tendency toward the fitting of more and more complex models, with the potential negative implications of this endeavor (which I will loosely term ‘overfitting’) being lost amid the enthusiasm for bigger and allegedly ‘more realistic’ models. Those with such tendencies would definitely benefit from studying this book in order to gain insight into the unexpected consequences that some mixed model choices can have. All of the model types appearing in the title are covered in great detail, including coverage of diagnostics for mixed models, a sorely under-examined topic. Real data analyses are prominent in the discussions, with strange behavior of fitting being highlighted; for example, there is a section entitled, ‘Mysterious, inconvenient, or wrong results from real datasets.’ The author is not afraid to state an opinion, which is very refreshing; see, for example, the critique/gentle destruction of h-likelihood in Section 7.3. Open questions are also advertised and PhD students looking for research problems could do a lot worse than read this book. … an excellent, inspiring, and entertaining statistics book …"—Jon Wakefield, Professor of Statistics, University of Washington"This new book by James S. Hodges is different. Whereas others describe a polished version of the theme of the book, Hodges takes another approach. In a very personal writing style, Hodges explores what we do and do not understand about mixed linear models. Why does his approach work so well? It makes you think!!! By also discussing mysterious, inconvenient, or plainly wrong results, we simply gain more insight and understanding. This works for me; I have never gained so much (hard to get) insight in so short a time from any other book I have read. I highly recommend it!"—Håvard Rue, Norwegian University of Science and Technology "This book is a masterpiece, destined to become a classic. Linear mixed models are widely used by statisticians and analysts in many fields, often under other names: hierarchical, longitudinal, dynamic, random effects, multi-level, and others. Statistical packages routinely fit these models. Sometimes the packages return sensible results; sometimes not. Sometimes the user can tell whether the results are sensible; sometimes not. Oddities include ‘zero variance estimates, multiple maxima, counterintuitive outlier effects, odd fits (e.g., a wiggly smooth with one smoother but not with another apparently similar smoother), big changes in fit from apparently modest changes in the model or data, and unpredictable convergence of numerical routines,’ to quote from the book. There is not presently a unified theory, like that for linear regression, to explain how, why, and when our numerical routines give results that should be questioned, or at least examined further. Even so, this book does the best job I have seen of explaining what can go wrong and what the state of the art is.The subject is important; the writing is excellent; and the examples are compelling. I am excited by the prospect of teaching a course from this book. Its clarity of thought and presentation are exemplary. I recommend it for anyone who fits complicated models."—Michael Lavine, University of Massachusetts Amherst

• Mixed Linear Models: Syntax, Theory, and Methods: An Opinionated Survey of Methods for Mixed Linear Models. Two More Tools: Alternative Formulation, Measures of Complexity. Richly Parameterized Models as Mixed Linear Models: Penalized Splines as Mixed Linear Models. Additive Models and Models with Interactions. Spatial Models as Mixed Linear Models. Time-Series Models as Mixed Linear Models. Two Other Syntaxes for Richly Parameterized Models. From Linear Models to Richly Parameterized Models: Mean Structure: Adapting Diagnostics from Linear Models. Puzzles from Analyzing Real Datasets. A Random Effect Competing with a Fixed Effect. Differential Shrinkage. Competition between Random Effects. Random Effects Old and New. Beyond Linear Models: Variance Structure: Mysterious, Inconvenient, or Wrong Results from Real Datasets. Re-Expressing the Restricted Likelihood: Two-Variance Models. Exploring the Restricted Likelihood for Two-Variance Models. Extending the Re-Expressed Restricted Likelihood. Zero Variance Estimates. Multiple Maxima in the Restricted Likelihood and Posterior.