Roberta Capello is Full Professor of Regional and Urban Economics at Politecnico di Milano. She is the editor in chief of Papers in Regional Science, founder and editor in chief of the Italian Journal of Regional Science (2020-2020) and past president of the Regional Science Association International (2009-2010). She is the author of a textbook Regional Economics, published in English (Routledge, London), Italian (Il Mulino, Bologna) and Chinese (Economy and Management Publishing House, Beijing).Camilla Lenzi is Associate Professor of Regional and Urban Economics at Politecnico di Milano. She has published on several international refereed journals, including Journal of Urban Economics, Urban Studies, Regional Studies and Journal of Regional Science, and participated in several EU funded projects (ESPON, FP6 and FP7). She is on the editorial board of Papers in Regional Science.

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• Introduction: An inquiry on regional trends and impacts of the 4.0 technological transformations Part I. Setting the scene: definition and impacts of 4.0 technological transformations 1: The 4.0 technological transformations and their regional socio-economic dimension 2: The regional economic effects of 4.0 technological transformations 3: 4.0 technological transformations and the local labour markets Part II. 4.0 technological transformations in European regions 4: From conceptual definitions to empirical measurements: logics, methods and data 5: Transformation in the market for the new technologies: 4.0 inventing regions 6: Regional technological transformation patterns in Europe Part III. Socio-economic impacts of 4.0 technological transformations in European regions 7: Regional economic effects of 4.0 technological transformations 8: Effects on the regional labour market Part IV. Concluding remarks 9. Conclusions and policy implications References

Roberta Capello is Full Professor of Regional and Urban Economics at Politecnico di Milano. She is the editor in chief of Papers in Regional Science, founder and editor in chief of the Italian Journal of Regional Science (2020-2020) and past president of the Regional Science Association International (2009-2010). She is the author of a textbook Regional Economics, published in English (Routledge, London), Italian (Il Mulino, Bologna) and Chinese (Economy and Management Publishing House, Beijing).Camilla Lenzi is Associate Professor of Regional and Urban Economics at Politecnico di Milano. She has published on several international refereed journals, including Journal of Urban Economics, Urban Studies, Regional Studies and Journal of Regional Science, and participated in several EU funded projects (ESPON, FP6 and FP7). She is on the editorial board of Papers in Regional Science.

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• Introduction: An inquiry on regional trends and impacts of the 4.0 technological transformations Part I. Setting the scene: definition and impacts of 4.0 technological transformations 1: The 4.0 technological transformations and their regional socio-economic dimension 2: The regional economic effects of 4.0 technological transformations 3: 4.0 technological transformations and the local labour markets Part II. 4.0 technological transformations in European regions 4: From conceptual definitions to empirical measurements: logics, methods and data 5: Transformation in the market for the new technologies: 4.0 inventing regions 6: Regional technological transformation patterns in Europe Part III. Socio-economic impacts of 4.0 technological transformations in European regions 7: Regional economic effects of 4.0 technological transformations 8: Effects on the regional labour market Part IV. Concluding remarks 9. Conclusions and policy implications References

Roberta Capello is Full Professor of Regional and Urban Economics at Politecnico di Milano. She is the editor in chief of Papers in Regional Science, founder and editor in chief of the Italian Journal of Regional Science (2020-2020) and past president of the Regional Science Association International (2009-2010). She is the author of a textbook Regional Economics, published in English (Routledge, London), Italian (Il Mulino, Bologna) and Chinese (Economy and Management Publishing House, Beijing).Camilla Lenzi is Associate Professor of Regional and Urban Economics at Politecnico di Milano. She has published on several international refereed journals, including Journal of Urban Economics, Urban Studies, Regional Studies and Journal of Regional Science, and participated in several EU funded projects (ESPON, FP6 and FP7). She is on the editorial board of Papers in Regional Science.

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• Introduction: An inquiry on regional trends and impacts of the 4.0 technological transformations Part I. Setting the scene: definition and impacts of 4.0 technological transformations 1: The 4.0 technological transformations and their regional socio-economic dimension 2: The regional economic effects of 4.0 technological transformations 3: 4.0 technological transformations and the local labour markets Part II. 4.0 technological transformations in European regions 4: From conceptual definitions to empirical measurements: logics, methods and data 5: Transformation in the market for the new technologies: 4.0 inventing regions 6: Regional technological transformation patterns in Europe Part III. Socio-economic impacts of 4.0 technological transformations in European regions 7: Regional economic effects of 4.0 technological transformations 8: Effects on the regional labour market Part IV. Concluding remarks 9. Conclusions and policy implications References