Handbook of Drug Metabolism, Third Edition

PAUL G. PEARSON is President and CEO, Pearson Pharma Partners, Westlake Village, California, USA. Dr. Pearson received his Ph.D. in Pharmaceutical Sciences from Aston University, Birmingham, UK. He has had an extensive and successful career in pharmaceutical science, previously serving as Vice President of Pharmacokinetics and Drug Metabolism at Amgen, Inc. and Executive Director of Preclinical Drug Metabolism at Merck & Co, Inc. He is an active member of several international and national professional organizations. Dr. Pearson has contributed to numerous peer-reviewed publications and has been an honored invited lecturer at conferences, society meetings, and symposia on drug development, drug metabolism, and drug discovery. Dr Pearson is actively engaged in the discovery and development of new human therapeutics to make a drammatic difference to the lives of patients.LARRY C. WIENKERS is Principal Scientist, Wienkers Consulting, Bainbridge Island Washington, USA. Prior to consulting, Dr Wienkers served as Vice President of Pharmacokinetics and Drug Metabolism at Amgen, Inc. and Senior Director of Pharmacokinetics, Dynamics, and Metabolism at Pfizer. He obtained his Ph.D. in Medicinal Chemistry from the University of Washington, Seattle, Washington, USA and in 2014 he was awarded the University of Washington, School of Pharmacy Distinguished Alumni Award in Pharmaceutical Science and Research. Larry is a member of several professional societies, where he has served as Chair of American Society of Pharmacology and Experimental Therapeutics Division of Drug Metabolism and in 2013 was elected as Fellow in the American Association of Pharmaceutical Scientists. Dr. Wienkers has published over 80 peer-reviewed publications and book chapters has been an invited lecturer at conferences and symposia on large and small molecule drug metabolism and drug discovery.

The compendium is split into sections on; Fundamental aspects of drug metabolism, Factors which affect drug metabolism, Technologies to study drug metabolism, and Application of metabolism studies in drug discovery and development. Each chapter is well laid out with clear and useful figures and well referenced. As someone who wanted to know more about this field and having a basic knowledge, this was a good read. The chapters on enzyme inhibition and the genetic basis of variation in drug metabolism and toxicity were particularly good.-Prof. Dudley E. Shallcross, University of Bristol, UK

• Fundamental Aspects of Drug Metabolism. Factors Which Affect Drug Metabolism. Technologies to Study Drug Metabolism. Applications of Metabolism Studies in Drug Discovery and Development.