Jing Cai, PhD, is an associate professor of Radiation Oncology at Duke University Medical Center. His research is focused on developing and clinically implementing novel image-guided radiation therapy techniques. He has published more than 50 peer-reviewed journal articles and over 130 conference abstracts. He regularly provides scientific reviews for journals and conferences, and servers as expert reviewer for grant applications. His research has received federal, charitable, and industrial funding. Joe Y. Chang, MD, PhD, is professor in the Department of Radiation Oncology at The University of Texas MD Anderson Cancer Center in Houston. He is also Clinical Section Chief for Thoracic Radiation Oncology and Director of the Stereotactic Radiotherapy Program. He earned his PhD in cancer biology at the University of Texas MD Anderson Cancer Center, and earned his MD from Shanghai Medical College in China. He performed clinical residency at Rush-Presbyterian St. Luke Medical Center in Chicago. He is board certified in radiation oncology, and is recipient of numerous honors and is an active member of several professional organizations.Fang-Fang Yin, PhD, is director of the DKU Medical Physics program. He has served as Chief of the Division of Radiation Physics and Professor of Radiation Oncology at Duke University since 2004. The author of more than 200 refereed publications and book chapters, Yin’s research interests include image-guided radiation therapy, informatics in cancer treatment, advanced planning and delivery techniques, and quality assurance. Yin is a Fellow and Member-at Large of the Board of Directors of the American Association of Physicists in Medicine (AAPM). He earned his Ph.D. in Medical Physics from the University of Chicago.

• Series PrefacePrefaceEditorsContributorsPart 1 INTRODUCTION1 Overview of IGRTFang-Fang Yin, Yu Yan, and Robert Timmerman2 History and future of IGRT in lung cancerJoe Y. ChangPart 2 PRINCIPLES OF IGRT FOR LUNG CANCER3 Imaging simulation for lung cancer IGRTDaniel Low, Tinsu Pan, Ning Wen, and Carri K. Glide-Hurst4 Treatment planningYan Yu, Kamila Nowak Choi, and Virginia Lockamy5 Treatment verification and deliveryNing Wen, Carri Glide-Hurst, Karen Chin Snyder, Mischa Hoogeman, Martina Descovich, Lei Ren, and Indrin Chetty6 Quality assurance of IGRTKrishni Wijesooriya, Taeho Kim, Josh Evans, and Quan ChenPart 3 PRACTICE OF IGRT FOR LUNG CANCER 1257 L-shaped linacsDavid Hoffman, Julian Perks, Steve Goetsch, and Stanley Benedict8 TomoTherapyKe Sheng9 Robotic arm linacJun Yang, Andrew Cardin, Jing Feng, Xing Liang, and EnMing Wang10 Proton therapyClemens Grassberger, Gregory C. Sharp, and Harald Paganetti11 Application of IGRT for lung stereotactic body radiotherapyJulianne M. Pollard-Larkin, Peter Balter, and Joe Y. Chang12 Uncertainties of IGRT for lung cancerIrina Vergalasova, Guang Li, Chris R. Kelsey, Hong Ge, Long Huang, and Jing CaiPart 4 ADVANCES IN IGRT FOR LUNG CANCER13 Advances in imaging simulation for lung cancer IGRTJing Cai, Daniel Low, Tinsu Pan, Yilin Liu, Zheng Chang, and Wei Lu14 Advances in treatment planningMei Li, Ruijiang Li, and Lei Xing15 Advances in verification and delivery techniquesLei Ren, Martina Descovich, and Jing Wang16 Treatment response assessment and response guided adaptive treatmentTim Lautenschlaeger, Martha Matuszak, and Feng-Ming (Spring) Kong17 Adaptive radiation therapy for lung cancerMartha Matuszak, Kristy K. Brock, and Feng-Ming (Spring) Kong18 MRI-based IGRT for lung cancerRojano Kashani and Lauren HenkeIndex

Jing Cai, PhD, is an associate professor of Radiation Oncology at Duke University Medical Center. His research is focused on developing and clinically implementing novel image-guided radiation therapy techniques. He has published more than 50 peer-reviewed journal articles and over 130 conference abstracts. He regularly provides scientific reviews for journals and conferences, and servers as expert reviewer for grant applications. His research has received federal, charitable, and industrial funding. Joe Y. Chang, MD, PhD, is professor in the Department of Radiation Oncology at The University of Texas MD Anderson Cancer Center in Houston. He is also Clinical Section Chief for Thoracic Radiation Oncology and Director of the Stereotactic Radiotherapy Program. He earned his PhD in cancer biology at the University of Texas MD Anderson Cancer Center, and earned his MD from Shanghai Medical College in China. He performed clinical residency at Rush-Presbyterian St. Luke Medical Center in Chicago. He is board certified in radiation oncology, and is recipient of numerous honors and is an active member of several professional organizations.Fang-Fang Yin, PhD, is director of the DKU Medical Physics program. He has served as Chief of the Division of Radiation Physics and Professor of Radiation Oncology at Duke University since 2004. The author of more than 200 refereed publications and book chapters, Yin’s research interests include image-guided radiation therapy, informatics in cancer treatment, advanced planning and delivery techniques, and quality assurance. Yin is a Fellow and Member-at Large of the Board of Directors of the American Association of Physicists in Medicine (AAPM). He earned his Ph.D. in Medical Physics from the University of Chicago.

• Series PrefacePrefaceEditorsContributorsPart 1 INTRODUCTION1 Overview of IGRTFang-Fang Yin, Yu Yan, and Robert Timmerman2 History and future of IGRT in lung cancerJoe Y. ChangPart 2 PRINCIPLES OF IGRT FOR LUNG CANCER3 Imaging simulation for lung cancer IGRTDaniel Low, Tinsu Pan, Ning Wen, and Carri K. Glide-Hurst4 Treatment planningYan Yu, Kamila Nowak Choi, and Virginia Lockamy5 Treatment verification and deliveryNing Wen, Carri Glide-Hurst, Karen Chin Snyder, Mischa Hoogeman, Martina Descovich, Lei Ren, and Indrin Chetty6 Quality assurance of IGRTKrishni Wijesooriya, Taeho Kim, Josh Evans, and Quan ChenPart 3 PRACTICE OF IGRT FOR LUNG CANCER 1257 L-shaped linacsDavid Hoffman, Julian Perks, Steve Goetsch, and Stanley Benedict8 TomoTherapyKe Sheng9 Robotic arm linacJun Yang, Andrew Cardin, Jing Feng, Xing Liang, and EnMing Wang10 Proton therapyClemens Grassberger, Gregory C. Sharp, and Harald Paganetti11 Application of IGRT for lung stereotactic body radiotherapyJulianne M. Pollard-Larkin, Peter Balter, and Joe Y. Chang12 Uncertainties of IGRT for lung cancerIrina Vergalasova, Guang Li, Chris R. Kelsey, Hong Ge, Long Huang, and Jing CaiPart 4 ADVANCES IN IGRT FOR LUNG CANCER13 Advances in imaging simulation for lung cancer IGRTJing Cai, Daniel Low, Tinsu Pan, Yilin Liu, Zheng Chang, and Wei Lu14 Advances in treatment planningMei Li, Ruijiang Li, and Lei Xing15 Advances in verification and delivery techniquesLei Ren, Martina Descovich, and Jing Wang16 Treatment response assessment and response guided adaptive treatmentTim Lautenschlaeger, Martha Matuszak, and Feng-Ming (Spring) Kong17 Adaptive radiation therapy for lung cancerMartha Matuszak, Kristy K. Brock, and Feng-Ming (Spring) Kong18 MRI-based IGRT for lung cancerRojano Kashani and Lauren HenkeIndex

Jing Cai, PhD, is an associate professor of Radiation Oncology at Duke University Medical Center. His research is focused on developing and clinically implementing novel image-guided radiation therapy techniques. He has published more than 50 peer-reviewed journal articles and over 130 conference abstracts. He regularly provides scientific reviews for journals and conferences, and servers as expert reviewer for grant applications. His research has received federal, charitable, and industrial funding. Joe Y. Chang, MD, PhD, is professor in the Department of Radiation Oncology at The University of Texas MD Anderson Cancer Center in Houston. He is also Clinical Section Chief for Thoracic Radiation Oncology and Director of the Stereotactic Radiotherapy Program. He earned his PhD in cancer biology at the University of Texas MD Anderson Cancer Center, and earned his MD from Shanghai Medical College in China. He performed clinical residency at Rush-Presbyterian St. Luke Medical Center in Chicago. He is board certified in radiation oncology, and is recipient of numerous honors and is an active member of several professional organizations.Fang-Fang Yin, PhD, is director of the DKU Medical Physics program. He has served as Chief of the Division of Radiation Physics and Professor of Radiation Oncology at Duke University since 2004. The author of more than 200 refereed publications and book chapters, Yin’s research interests include image-guided radiation therapy, informatics in cancer treatment, advanced planning and delivery techniques, and quality assurance. Yin is a Fellow and Member-at Large of the Board of Directors of the American Association of Physicists in Medicine (AAPM). He earned his Ph.D. in Medical Physics from the University of Chicago.

• Series PrefacePrefaceEditorsContributorsPart 1 INTRODUCTION1 Overview of IGRTFang-Fang Yin, Yu Yan, and Robert Timmerman2 History and future of IGRT in lung cancerJoe Y. ChangPart 2 PRINCIPLES OF IGRT FOR LUNG CANCER3 Imaging simulation for lung cancer IGRTDaniel Low, Tinsu Pan, Ning Wen, and Carri K. Glide-Hurst4 Treatment planningYan Yu, Kamila Nowak Choi, and Virginia Lockamy5 Treatment verification and deliveryNing Wen, Carri Glide-Hurst, Karen Chin Snyder, Mischa Hoogeman, Martina Descovich, Lei Ren, and Indrin Chetty6 Quality assurance of IGRTKrishni Wijesooriya, Taeho Kim, Josh Evans, and Quan ChenPart 3 PRACTICE OF IGRT FOR LUNG CANCER 1257 L-shaped linacsDavid Hoffman, Julian Perks, Steve Goetsch, and Stanley Benedict8 TomoTherapyKe Sheng9 Robotic arm linacJun Yang, Andrew Cardin, Jing Feng, Xing Liang, and EnMing Wang10 Proton therapyClemens Grassberger, Gregory C. Sharp, and Harald Paganetti11 Application of IGRT for lung stereotactic body radiotherapyJulianne M. Pollard-Larkin, Peter Balter, and Joe Y. Chang12 Uncertainties of IGRT for lung cancerIrina Vergalasova, Guang Li, Chris R. Kelsey, Hong Ge, Long Huang, and Jing CaiPart 4 ADVANCES IN IGRT FOR LUNG CANCER13 Advances in imaging simulation for lung cancer IGRTJing Cai, Daniel Low, Tinsu Pan, Yilin Liu, Zheng Chang, and Wei Lu14 Advances in treatment planningMei Li, Ruijiang Li, and Lei Xing15 Advances in verification and delivery techniquesLei Ren, Martina Descovich, and Jing Wang16 Treatment response assessment and response guided adaptive treatmentTim Lautenschlaeger, Martha Matuszak, and Feng-Ming (Spring) Kong17 Adaptive radiation therapy for lung cancerMartha Matuszak, Kristy K. Brock, and Feng-Ming (Spring) Kong18 MRI-based IGRT for lung cancerRojano Kashani and Lauren HenkeIndex