Mild Cognitive Impairment

Holly A. Tuokko was a Professor in the Department of Psychology and Institute on Aging and Lifelong Health at the University of Victoria. She was awarded Senior Investigator status through the Canadian Institutes of Health Research, Institute of Aging (2002–2007), for her program of research on mental health and aging. David F. Hultsch was a Professor of Psychology at the University of Victoria from 1984 onward, with a major research focus on cognition and aging. He was a founder of the journal Aging, Neuropsychology, and Cognition, serving as co-editor for 10 years.

"This valuable volume brings the kind of broad perspective to mild cognitive impairment that has long been needed. Rather than basing conclusions on a single sample or framework, the editors have pulled together articles from leading research groups around the world. This is the kind of comprehensive approach that is needed for developing systematic and valid definitions of MCI and identifying better tools that make it possible to differentiate between benign memory changes in later life and the early signs of pathological processes." - Steven H. Zarit, Department of Human Development and Family Studies, The Pennsylvania State University, USA."This volume provides the most comprehensive overview of mild cognitive impairment currently available. The conceptual and methodological challenges for studying MCI are tackled with rigor, and the complexities of defining the syndrome are not underestimated. This book is certain to become a classic text for those studying or researching cognitive agin, MCI and dementia, and for clinicians seeking an authoritative reference on the clinical manifestations of MCI." - Kaarin J. Anstey, Centre for Mental Health Research, Australian National University, Australia. "The editors of this book have done a great job. The description of the issues is laid out in a well-written introduction, making the descriptions of the research papers very accessible, even to the less well-informed reader. The conclusion likewise pulled together the various strands, including defining what still needs to be done to further refine the concept of MCI." - Graham A. Jackson, Laverndale Hospital, Scotland. In Dementia, August, 2008.

• About the editors List of contributorsFrom the series editorIntroduction to the Classic EditionPart IIntroduction An overview of mild cognitive impairment HOLLY A. TUOKKO AND IAN MCDOWELLPart IIGeneral Population Research on MCI 2 The PAQUID study COLETTE FABRIGOULE, PASCALE BARBERGER-GATEAU, AND JEAN-FRANÇOIS DARTIGUES3 Cognitive impairment in elderly persons without dementia: Findings from the Kungsholmen ProjectKATIE PALMER, LARS BACKMAN, BRENT J. SMALL, AND LAURA FRATIGLIONI4 Population levels of mild cognitive impairment in England and Wales JANE FLEMING, FIONA E. MATTHEWS, MARK CHATFIELD, AND CAROL BRAYNE5 The Melbourne Aging StudyALEXANDER COLLIE, PAUL MARUFF, DAVID G. DARBY, COLIN MASTERS, AND JON CURRIEPart IIISpecific Samples6 Mild cognitive impairment in the Religious Orders StudyROBERT S. WILSON, NEELUM T. AGGARWAL, AND DAVID A. BENNETT 7 A perspective from the Mayo ClinicGLENN SMITH, MARY MACHULDA, AND KEJAL KANTARCI 8 Prediction of probable Alzheimer's disease: The Sunnybrook Memory StudyMARY C. TIERNEY 9 Studies in the Leipzig Memory Clinic: Contribution to the concept of mild cognitive impairmentHENRIKE WOLF AND HERMANN-JOSEF GERTZPart IV Interventions 10 Emerging pharmacological therapies for mild cognitive impairmentHOWARD CHERTKOW11 Cognition-based therapies and mild cognitive impairment ROBERT T. WOODS AND LINDA CLARE 12 Combined therapies in mild cognitive impairmentKEVIN PETERS AND GORDON WINOCURPart VSummary and Future Directions 13 The future of mild cognitive impairmentHOLLY A. TUOKKO AND DAVID F. HULTSCHAuthor indexSubject index