Laurie S. Kaguni is at Michigan State University, MI, USA Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.

• I. Introduction1. History of The Enzymes Fuyuhiko Tamanoi,2. Impact of The Enzymes in chronicling biochemical processes and pathwaysLaurie S. KaguniII. Metabolism and Catalysis3. Mitochondrial ATP synthaseJohn Walker4. The respiratory chainMårten Wikström5. A century of mitochondrial researchHoward Jacobs6. Five decades of metalloenzymologyRobert P. Hausinger7. Mechanisms of catalysisKenneth Allen Johnson8. Mitochondrial fatty acid synthesis and associated processesAlexander KastaniotisIII. Signaling9. MAPK cascades: Origins, mechanisms and current statusJeremy Thorner10. Sphingolipids: From structural components to signaling hubsJohnny Stiban and Saurav MajumderIV. Protein Homeostasis and Hydrolysis11. Mitochondrial AAA+ proteasesYuichi Matsushima12. Hsp70 and JDP proteins: structure-function perspective on molecular chaperone activitySzymon CiesielskiV. DNA Replication and Repair13. Structure-function studies of DNA replication proteinsBorja Ibarra14. Helicases required for nucleotide excision repairLi Fan