Neuroglia in the Healthy Nervous System, Part I

Elly Hol is professor of “Glia biology of brain diseases” at the Utrecht University and professor of "Biology of glia and neural stem cells” at the University of Amsterdam. Her research is focused on the role of glial cells in brain diseases, including Alzheimer’s disease, stroke, schizophrenia and glioma. The overall aim is to elucidate the molecular and functional changes in glia that contribute to the pathogenesis of neurological and psychiatric diseases. Her work is translational and includes studies on glial cells in human post-mortem brain tissue, in human cell models, and in mouse models for brain diseases. She is a member of Academia Europaea, member of the editorial board of Glia, chair of the scientific advisory board of Alzheimer Nederland, chair of GliaNed, director of the Neuroscience Master and PhD program of the Utrecht University Graduate School of Life Sciences, and director of education for the Division Brain at the UMCU. Dr. de Witte is a psychiatrist with a background in preclinical research in the fields of virology and immunology. She is an MD PhD interested in how the immune system plays a role in psychotic disorders. In parallel to her residencies in psychiatry, she started her own research group at the Brain Center Rudolf Magnus in Utrecht, the Netherlands investigating the prevalence and role of neuronal auto-antibodies and neurotropic pathogens in psychotic disorders. He research has resulted in a novel and distinctive research line studying the phenotype and function of microglia in psychotic disorders. Prof. E.M.A. Aronica is professor of Neuropathology at the University of Amsterdam’s Faculty of Medicine (AMC-UvA). Her research focuses on understanding the pathogenesis, epileptogenesis and pharmacoresistance of focal chronic pharmacoresistant epilepsy, as well as featuring translational aspects. The aim is to find an effective treatment for patients with epilepsy by mapping biological and molecular signalling pathways that contribute towards the development and progression of epilepsy and associated comorbidity. Aronica studies the control mechanisms of inflammatory processes, microRNAs, biomarkers to predict and diagnose the development of disease. Aronica focuses on neuropathological and applied research for patients with neurological diseases. She has published more than 300 peer-reviewed articles and several chapters for books. Professor Alexei Verkhratsky, PhD, DSc, is an internationally recognised scholar in the field of cellular neurophysiology, best known for his contributions to our knowledge of the physiology and pathophysiology of neuroglia. He started glial research in 1989 in Heidelberg in the laboratory of Helmut Kettenmann. In a series of highly cited conceptual papers, he outlined basic principles of glial physiology and pathophysiology, which significantly influenced this rapidly developing area of neuroscience.

• 1. Neuroglia in the healthy brain: An introduction2. Evolution of neuroglia: from worm to man3. Orchestrating the glial compartment: ontogeny and developmental interaction of astrocytes, oligodendrocytes, and microglia4. Glia and aging (rodent/human)5. Physiology of neuroglia of the central nervous system6. Gliotransmission in physiological and pathological conditions7. Glia and brain energy metabolism8. Neuroglia and the blood-brain barrier9. Metabolic control of microglia in health and disease10. The glymphatic system11. Glia and brain-gut axis (rodent/human)12. Glia and extracellular matrix molecules13. In vitro models for human neuroglia14. Animal-based approaches to understanding glia physiology in vitro and in vivo15. Single-cell omics and heterogeneity of neuroglial cells16. Imaging neuroglia