Handbook of Clinical Neurology – serie

The Handbook of Clinical Neurology Vol 101: Muscular Dystrophies discusses the pathogenesis and treatment prospects for muscular dystrophies. It summarizes the advances in molecular and cell biology, biochemistry, and other biological sciences, with an emphasis on their application to this group of muscle disorders and to their clinical implications.

Starting with an overview of muscular dystrophies, the book's 16 chapters discuss dystrophinopathies; sarcoglycanopathies; congenital muscular dystrophies; collagen VI-related myopathies; limb-girdle muscular dystrophy 2A; dysferlinopathies; limb-girdle muscular dystrophy 2H and the role of TRIM32; and caveolinopathies. The book also covers myofibrillar myopathies; Emery-Dreifuss muscular dystrophy; facioscapulohumeral dystrophy and scapuloperoneal syndromes; oculopharyngeal muscular dystrophy; myotonic dystrophy types 1 and 2; and distal muscular dystrophies.

This book is useful to basic investigators, as it offers an increased understanding of muscular dystrophies; and to clinicians, with its emphasis on issues that are relevant to the care, diagnosis, and management of patients with these disorders.

Valuable insights into the muscular dystrophies, including treatment, diagnosis, and care and patient management A comprehensive compilation of the combined wisdom of the most highly regarded physicians, experts, and scientists studying the muscular dystrophies An evaluation of the way advances in molecular and cell biology, biochemistry, and other biological sciences continue to advance the study of these disorders

Functional Neurologic Disorders, the latest volume in the Handbook of Clinical Neurology series, summarizes state-of-the-art research findings and clinical practice on this class of disorders at the interface between neurology and psychiatry. This 51-chapter volume offers an historical introduction, chapters on epidemiology and pathophysiolology, a large section on the clinical features of different type of functional neurologic symptoms and disorders (including functional movement disorders, non-epileptic seizures, dizziness, vision, hearing, speech and cognitive symptoms), and then concluding with approaches to therapy.

This group of internationally acclaimed experts in neurology, psychiatry, and neuroscience represent a broad spectrum of areas of expertise, chosen for their ability to write clearly and concisely with an eye toward a clinical audience. This HCN volume sets a new landmark standard for a comprehensive, multi-authored work dealing with functional neurologic disorders (also described as psychogenic, dissociative or conversion disorders).

Offers a comprehensive interdisciplinary approach for the care of patients with functional disorders seen in neurologic practice, leading to more efficient prevention, management, and treatment Provides a synthesis of research efforts incorporating clinical, brain imaging and neurophysiological studies Fills an existing gap between traditional neurology and traditional psychiatry Contents include coverage of history, epidemiology, clinical presentations, and therapy Edited work with chapters authored by leaders in the field, the broadest, most expert coverage available

Huntington Disease summarizes the most recent findings related to the disease, providing both cutting edge coverage for clinical/research specialists looking to expand their knowledge base of Huntington disease information, as well as solid groundwork for advanced students from various backgrounds (neurology, psychiatry, neuropsychology, genetics). The volume includes all major areas of Huntington disease clinical care and research, whereas many other HD texts focus solely on neurological symptoms.

This book also addresses behavioral and cognitive symptoms, brain imaging, and family dynamics and therapeutic alliances in working with individuals affected by HD. Clinical trials are covered extensively, including design considerations for therapeutic studies. The devastating nature of Huntington's disease is well appreciated throughout the neuroscience, neurology, and psychiatric communities, and a great amount of basic and clinical research is currently taking place. However, much of that occurs in isolated research silos, and it is critical that an interdisciplinary resource be developed to provide in depth information to enhance communication and collaboration. This volume in the Handbook of Clinical Neurology series is that resource.

Includes coverage of both basic science and clinical aspects of the disease, as well as treatment, experimental therapeutics, and biomarkers Provides an essential resource for the non-neurologist, including necessary background for understanding the disease before making a more detailed study proposal Provides an interdisciplinary approach that can be applied in everyday clinic and research efforts Features chapters edited by leaders in the field around the globe-the broadest expert coverage available

Neuropathology, Volume 145, the latest release in the Handbook of Clinical Neurology series, includes all the major topics found in a typical neuropathology text, but differentiates itself by providing a thorough overview of the morphological background of neurological disorders for researchers and clinicians who do not specialize in pathology or its clinicopathological aspects. This volume offers strong coverage of brain imaging and advances in molecular pathology and genetics, and is particularly timely given the amount of neuropathological research currently taking place.

Provides a resource for the non-pathologist, aiding primary clinicians and researchers in the interpretation of patient symptoms and research findings Includes standard neuropathology, but extends to clinicopathology, imaging and molecular pathology/genetics Presents an interdisciplinary approach that can be applied in everyday clinic and research efforts

Neuroepidemiology covers the foundations of neuroepidemiological research and the epidemiology of disorders primarily affecting the nervous system, as well as those originating outside the nervous system. The etiology of many important central nervous system disorders remains elusive. Even with diseases where the key risk determinants have been identified, better prevention and therapy is needed to reduce high incidence and mortality. Although evolving technologies for studying disease provide opportunities for such, it is essential for researchers and clinicians to understand how best to apply such technology in the context of carefully characterized patient populations.

By paying special attention to methodological approaches, this volume prepares new investigators from a variety of disciplines to conduct epidemiological studies in order to discern the etiologic factors and underlying mechanisms that influence the onset, progression, and recurrence of CNS disorders and diseases. The book also provides current information on methodological approaches for clinical neurologists seeking to expand their knowledge in research.

Includes coverage of the foundations of neuroepidemiological research and the epidemiology of disorders primarily affecting the nervous system, as well as those originating outside the nervous system Describes the most recent methodologies to define and quantify the burden of CNS disorders and to understand the underlying mechanisms, with neuroimaging and molecular methods receiving particular emphasis Offers extensive description of those neurological conditions that are secondary to other diseases whose incidence is on the rise because of longer survival rates Features chapters authored by leaders in the field from around the globe

Researchers' knowledge of gliomas continues to advance rapidly at both the basic and translational levels, and Gliomas provides a thorough overview of the evolving fields of tumor biology and clinical medicine as they relate to our understanding of brain tumors.

Gliomas reviews the current paradigms that underlie these fields, beginning with the molecular epidemiology of glioma susceptibility and prognosis through population-based science and genome-wide association studies. The book's discussion of imaging modalities extends beyond advances in anatomical imaging to include metabolic and physiological studies. This work provides thorough discussion of the clinical view of tumors, ranging from the presentation of the patient to surgical management, and covers all therapeutic options for patient care, including chemotherapy, targeted molecular therapies, immunotherapies, and even personalized approaches to impact the set of lesions. Additionally, the book discusses radiotherapy with regard to the many options available to treat patients using myriad fractionated techniques with various sources. Finally, Gliomas reviews issues specific to the quality of life for patients, and techniques for maximizing the effect of caregivers.

Edited and authored by premier researchers from around the world, Gliomas is a comprehensive reference for clinicians and researchers seeking the most up-to-date information on gliomas, and a guide to the best ways to effectively manage glioma patients and their care.

Synthesizes widely dispersed information on the management of gliomas into one comprehensive resource Chapters written by international authors who are preeminent researchers in the field Fully explores the therapeutic options for patient care, from chemotherapy to radiotherapy to personalized approaches

Cerebrospinal Fluid in Neurologic Disorders, Volume 146 provides a brief overview on the current use of CSF in clinical routine, the physiology of CSF, and its usefulness and potential as a biomarker. The second part addresses the main purpose of the volume, describing CSF from a research perspective in context with the most important diagnostic entities in neurology. The book's authors provide insight into the current understanding of CSF changes in these various conditions and what it tells us about the nature of neurological diseases. Furthermore, methodological aspects are discussed, as are shortcomings that need to be addressed.

Finally, the book provides an outlook for potential directions that can be explored to improve the various aspects of CSF research with the ultimate goal of being incorporated in clinical practice.

Provides a brief overview on the current use of CSF in clinical routine, the physiology of CSF, and its usefulness and potential as a biomarker Addresses relevant research in context with the most important diagnostic entities in neurology Edited by leading authors in CSF research from around the globe, presenting the broadest, most expert coverage available

The Frontal Lobes, Volume 163, updates readers on the latest thinking on the structure and function of the human frontal lobe. Sections address methodology, anatomy, physiology and pharmacology, function, development, aging and disorders, and rehabilitation. Patients with focal lesions in the frontal lobes have long been studied to reveal the organization and function of the frontal lobes. Over the last two decades, studies of patients with neurodegenerative diseases and developmental disorders have increased, with new findings discussed in this volume. In addition, the book includes discussions on genetics and molecular biology, optogenetics, high-resolution structural and functional neuroimaging and electrophysiology, and more.

Lastly, new knowledge on the biology, structure and function of the frontal lobes, new treatment targets for pharmacology, non-invasive brain stimulation, and cognitive/social remediation are presented. The last section covers new efforts that will hopefully lead to better outcomes in patients with frontal lobe disorders.

Provides an overview of the structure, function, disorder and rehabilitation of the frontal lobes Addresses a wide variety of methodologies - from genetics and molecular biology, to optogenetics and hi-res fMRI, and more Contains content of interest to advanced students, junior researchers and clinicians getting involved in research Features the input of leaders in neuroanatomical research from around the globe - the broadest, most expert coverage available

Geriatric Neurology, Volume 167, serves as an update on the basic biological and behavioral mechanisms underlying the aging process, with an emphasis on neurological aging and state-of-the-art reviews on our understanding of vascular, cognitive, neurodegenerative and neuropsychiatric diseases in the elderly. Developed with an eye to providing both the basic underpinnings of age-related changes and the clinical information necessary to aid in diagnostics and treatment, the book serves as a useful volume for students, basic and translational scientists, and practicing clinicians on how to understand and treat common neurological disorders in the elderly.

Reviews the foundations of geriatric neurology, including the fundamentals of age associated changes in molecular biology, altered pharmacokinetics and psychopharmacology that make drug therapy in the elderly different from younger patients Contains major advances in our understanding of neurodegenerative diseases Features contributions from world leaders in geriatric neurology-the broadest, most expert coverage available

Metastatic Disease of the Nervous System, Volume 149, begins with an overview of the impact and range of direct neoplastic involvement of the central and peripheral nervous system, comprehensively reviewing all aspects of brain metastases, from clinical, radiological and neuropathological manifestations, to the roles of surgery, radiation, systemic and palliative therapy in their management, and the complications of these interventions. The clinical manifestations, diagnosis and treatment of leptomeningeal, dural, spinal epidural and plexus metastases are also covered in detail.

Covers all aspects of brain metastases, from clinical, radiological and neuropathological manifestations, to the roles of surgery, radiation, systemic and palliative therapy Presents a multidisciplinary review of the evidence regarding accuracy of diagnostic testing and evidence-based reviews of therapies Addresses metastatic diseases of the nervous system for residents, fellows and clinicians in neurology and oncology

Neuroplasticity: From Bench to Bedside, Volume 184 in the Handbook of Clinical Neurology series, provides a comprehensive multidisciplinary guide to neuroplasticity. Sections summarize the basic mechanisms of neuroplasticity, focus on neuroplasticity in movement disorders, discuss brain oscillations in neurological disorders, segue into plasticity in neurorehabilitation, and cover issues of inflammation and autoimmunity in neuroplasticity. The book concludes with a section on neuroplasticity and psychiatric disorders. Covers basic mechanisms and clinical treatment approaches in neurological disorders Includes inflammation, autoimmunity, genetics, neurophysiology, and more Encompasses stroke, Alzheimer's, movement and psychiatric disorders Provides tools for enhancing recovery

Interoperative Monitoring, Volume 186 provides a concise overview of advances in interoperative monitoring targeted for clinical neurologists. It identifies techniques (EEG, ECoG, EMG, etc.), optimal anesthesia for use, safety issues to be considered, and then discusses advances as they relate to intracranial, spinal, peripheral nerve and vascular surgery. Best practices and case studies are included for all chapters as well as surgical microscope views, illustrations, and medical imaging. Identifies the best techniques for specific surgeries with details that include case studies Covers intracranial, spinal, peripheral nerve and vascular surgeries Specifies optimal anesthesia for use Addresses safety issues to be considered Utilizes surgical microscope views, illustrations and medical imaging

The Human Hypothalamus: Neuropsychiatric Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume identifies the neurobiology and neurophysiology of disorders relating to the hypothalamus and provides treatment information for these disorders. Disorders covered include neuropsychiatric, neurodegenerative, periodic, and autoimmune disorders. Coverage includes Alzheimer's, Parkinson's, epilepsy, sleep, pain, depression, anxiety, OCD, PTSD, schizophrenia, autism, aggressions, addiction, and more. Summarizes research on how the hypothalamus relates to neurological disorders Contains neuropsychiatric, neurodegenerative, periodic and autonomic disorders Includes the neurobiology of, and treatment for, each disorder Covers depression, anxiety, OCD, PTSD, schizophrenia, autism, aggression, addiction, and more Provides coverage of sleep and pain

The Hypothalamus is an important area of the brain for understanding a variety of neurological disorders. This volume summarizes for readers the anatomy and physiology of the anterior hypothalamus, to better understand pathology and treatment of hypothalamus related disorders. In addition to anatomy and physiology in humans, cytoarchitecture and chemoarchitecture in rodents is provided. The volume explores the role of the hypothalamus in disorders of eating, sleeping, anxiety, and mood, as well as its role in sexual behavior and gender identity. Coverage includes how Parkinson's, Alzheimer's and other neurological disorders relate to the hypothalamus.

Reviews the anatomy and physiology of the anterior hypothalamus Provides cytoarchitecture and chemoarchitecture from rodents Discusses hypothalamic related disorders of eating, sleeping, anxiety, and mood Covers how Parkinson's, Alzheimer's and other neurological disorders relate to the hypothalamus Explores the role of the hypothalamus in sexual behavior and gender identity

The Hypothalamus is an important area of the brain for understanding a variety of neurological disorders. This volume summarizes for readers the anatomy and physiology of the middle and posterior hypothalamus, to better understand pathology and treatment of hypothalamus related disorders. In addition to anatomy and physiology in humans, cytoarchitecture and chemoarchitecture in rodents is provided. The volume explores the role of the hypothalamus in disorders of eating, sleeping, anxiety, and mood, as well as its role in sexual behavior and gender identity. Coverage includes how Parkinson's, Alzheimer's and other neurological disorders relate to the hypothalamus.

Reviews the anatomy and physiology of the middle and posterior hypothalmus Provides cytoarchitecture and chemoarchitecture from rodents Discusses hypothalamic related disorders of eating, sleeping, anxiety, and mood Covers how Parkinson's, Alzheimer's and other neurological disorders relate to the hypothalamus Explores the role of the hypothalamus in sexual behavior and gender identity

The Human Hypothalamus: Neuroendocrine Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume summarizes the role of the hypothalamus in neuroendocrine disorders, identifying the mechanism of action, disorder etiology, and best practices for assessment and treatment. Disorders covered include pituitary hypothalamic disorders of development and growth, hypothalamic tumor related disorders, hypothalamic autoimmune disorders and infection, disorders of vasopressin, water and sodium homeostasis, eating disorders, and gonadotropic hormone regulation disorders. Discusses the importance of the hypothalamus in human growth and development Reviews hypothalamic related tumors, as well as pituitary, autoimmune, vasopressin and hormone regulation disorders Includes metabolic and eating disorders Identifies mechanisms of disease action and etiology Provides best practice information for assessment and treatment

Brain and Crime, Volume 197 reviews the relation between brain function and aggressive and rule-breaking (criminal) behavior.� The book's focus is on the violation of social rules and not on violation of regulations that are different in different counties. It discusses the development of this behavior from childhood into adulthood, along with the mechanisms associated with the risk for aggression and rule-breaking behavior.� In addition, it explores from a behavioral level concepts like psychopathology, syndrome and concepts from law, such as crime, defendant and offender. Finally, sections explore brain function, including emotion, cognitive processes, and decision-making.

From the perspective of brain structure, the book covers brain networks and brain disorders. In genetics, the book includes the influence of genes and the mechanisms of epigenetics. All chapters are intended to provide information for use in the diagnosis and treatment of disorders, and in assessment and prevention.

Discusses the development of rule-breaking (criminal) behavior from childhood into adulthood Covers the influence of genes and the mechanisms of epigenetics Includes the diagnosis and treatment of disorders, along with assessment and prevention

Neurology of Vision and Visual Disorders, Volume 178 in the Handbooks of Neurology series provides comprehensive summaries of recent research on the brain and nervous system. This volume reviews alterations in vision that stem from the retina to the cortex. Coverage includes content on vision and driving derived from the large amount of time devoted in clinics to determining who is safe to drive, along with research on the interplay between visual loss, attention and strategic compensations that may determine driving suitability. The title concludes with vision therapies and the evidence behind these approaches.

Each chapter is co-written by a basic scientist collaborating with a clinician to provide a solid underpinning of the mechanisms behind the clinical syndromes.

Reviews the neurological underpinnings of visual perception disorders Encompasses the cortex to the retina Covers functional organization, electrophysiology and subcortical visual pathways Discusses assessment, diagnosis and management of visual perception disorders Includes international experts from Australia, Canada, Denmark, Germany, Singapore, and the UK and US

Mitochondrial Diseases, Volume 194 presents the most common clinical manifestations, providing an up-to-date summaries on the clinical presentations, diagnostic processes, genetic counseling and treatment options in mitochondrial diseases. Contents include specialist biochemical analyses and targeted molecular genetic testing, as well as first-line genome-wide sequencing to accelerate speed of diagnosis while avoiding time-consuming, expensive and invasive investigations. Establishing a genetic diagnosis allows patients with mitochondrial diseases to have reproductive options, all of which are covered within.This book is intended for neurologists to help them recognize and manage patients with mitochondrial diseases. Examines the pathophysiology of mitochondrial diseases and disorders Focuses on neurological symptoms of mitochondrial diseases Presents myopathies, neuropathies, epilepsy, ataxia, paraplegias, and more Covers histology, metabolism, genetic, and neuroimaging diagnostics Summarizes both available and emerging therapies Includes clinical trials, the use of biomarkers and reproductive options

Disorders of Emotion in Neurologic Disease, Volume 183 in the Handbook of Clinical Neurology Series,�informs clinicians on which neurologic diseases are likely to have a secondary effect on emotion, what to look for in diagnosis, and best practices for treatment.� The book begins with an understanding of the neurological basis for emotions in order to better understand what goes awry in neurological disease.� It then discusses specific neurologic diseases and disorders affecting emotion. Reviews the neurology of emotions Specifies neurologic diseases that affect emotional expression Informs clinicians on how to diagnose, along with best practices for treatment Includes coverage of stroke, dementia, epilepsy, Huntington's, Parkinson's, TBI, and more

Migraine Biology, Diagnosis, and Co-Morbidities, Volume 198 covers a wide range of issues related to migraine. The epidemiology, global, and personal impacts of migraine are covered, including topics on the pathophysiology of migraine and migraine aura, the pathophysiology of the associated symptoms of photophobia and phonophobia, and the genetics of migraine. The classification and diagnostic criteria of common and uncommon subtypes of migraine are also explored in detail, including childhood variants. Issues related to the diagnosis and management of vestibular migraine and the co-morbid disorder of persistent postural-perceptual dizziness are also covered.Finally, the important comorbidities of migraine such as anxiety, depression and other forms of chronic pain are discussed, along with the current state and future directions of migraine research and management.

Summarizes research and clinical information on the pathophysiology of migrainesExplores the pathophysiology of aura, photophobia, and phonophobiaDiscusses migraine triggersReviews migraine subtypes and comorbid conditions in migraineExplores the relationship of migraine to chronic pain and cerebrovascular and psychological conditionsConcludes with future directions in migraine research and treatment

Migraine Management, Volume 199 covers the effective treatment of migraines, including different subtypes of migraines in different patient populations. The classification and diagnostic criteria of common and uncommon subtypes of migraine is explored in detail, including childhood variants. An in-depth analysis of the pharmacology of acute and prophylactic agents is presented, along with an evidence-based review of pharmacologic management. This includes recently developed CGRP monoclonal antibodies and non-peptide small molecule CGRP antagonists. Advances in neuromodulatory treatments, both noninvasive and implantable are also critically reviewed.Finally, specific treatment-related issues in pregnancy and lactation and childhood as well as the elderly are covered. Issues related to the diagnosis and management of vestibular migraine and the co-morbid disorder of persistent postural-perceptual dizziness are also explored.

Summarizes evidence-based best treatment for migrainesDifferentiates treatment based on patient population, migraine type, and clinical settingIncludes pharmacological, biobehavioral, and physical treatmentsProvides specialized treatments for children, the elderly, and pregnant patients

Aphasia, Volume 185 covers important advances in our understanding of how language is processed in the brain and how lesions or degeneration in the left hemisphere affect language processing. This new release reviews research regarding how language recovers from brain injury, along with new interventions developed to enhance recovery, including language rehabilitation, noninvasive brain stimulation and medications. Sections cover neuroanatomy and neurophysiology of language networks, focus on mechanisms of recovery (and decline) of language, and include chapters on intervention, including recently developed behavioral therapies, brain stimulation, medications, and a review of studies of treatment for both post-stroke aphasia and primary progressive aphasia. Summarizes advances made in understanding language processing Discusses how lesions and brain degeneration affect language production and comprehension Identifies language networks based on functional imaging and lesion mapping Provides interventions for recovery, including brain stimulation, behavioral interventions and medication Explores post-stroke aphasia and primary progressive aphasia

The Temporal Lobe, Volume 187 covers the exponential growth of studies on the relationships between brain and language/cognition, many of which involved the temporal lobe. This volume summarizes research on the anatomy and function of the temporal lobe under both normal and pathological conditions. In addition, it discusses the interactions of the temporal lobe with other brain structures. The book highlights the role of the temporal lobe in language processing as well as vision, object, face recognition and processing. The book also discusses the temporal lobe's role in reading, speech and the processing of color, music, action and memory.

Temporal lobe disorders, assessments and treatments are also covered, including encephalitis, Alzheimer's, epilepsy, Korsakov's syndrome, and more.

Summarizes research on the anatomy and function of the temporal lobe Identifies the importance of the temporal lobe to language and speech Includes how the temporal lobe interacts with other brain structures Reviews disorders of the temporal lobe, including dementia, encephalitis, and more

Paraneoplastic Neurological Disorders, Volume 200 covers new, recent descriptions of autoantibodies against neuronal cell surface antigens (only partly associated with paraneoplastic disorders) and the introduction of new immuno-oncological drugs that can contribute to diseases that are pathogenetically indistinguishable from paraneoplastic syndromes. Besides investigating the pathogenetic mechanisms of these disorders, this book also explores what the introduction of new drugs used in immune checkpoint inhibitor cancer therapy are teaching us in terms of immunopathogenesis. Following sections present individual syndromes (phenotypical clinical manifestations) of the CNS, PNS, NMJ, and muscle.Finally, the book investigates the role of antibody markers that differentiate by cytoplasmic, nuclear, and neuronal cell surface reactivities. Side effects of the new immuno-oncological drugs increasingly used in cancer therapy are also covered.

Profiles paraneoplastic diseases by tumor typeIdentifies the pathogenetic mechanisms of PNS and provides epidemiological analysisPresents individual syndromes of the CNS, PNS, NMJ, and muscleInvestigates the role of antibody markersDifferentiates cytoplasmic, nuclear, and neuronal cell surface reactivitiesDiscusses immune-oncological drugs causing diseases that are indistinguishable from PNSReviews therapeutic strategies and clinical approach to PNS patients

Vestibular Schwannomas covers multiple facets of vestibular schwannomas, including advancements in surgical techniques, radiological innovations, long-term patient outcomes, and implications for hearing preservation. It serves as a comprehensive guide for clinicians and researchers aiming to enhance diagnostic accuracy and therapeutic strategies in managing these complex tumors which are benign, slow-growing tumors that originate from the Schwann cells that line the vestibular nerve. They are the most prevalent neoplasms found in the cerebellopontine angle (CPA), the critical junction between the cerebellum and the brainstem.Their incidence, clinical presentation, and impact on surrounding neurological structures make them a focal point of research and medical intervention. Understanding their etiology, diagnosis, and treatment options requires an interdisciplinary approach bridging neurology, otology, and radiology.

Consolidates best practices on the diagnosis and treatment of vestibular schwannomasIncludes both sporadic and neurofibromatosis type 2 vestibular schwannomasCovers stereotaxic radiosurgery and microsurgical resectionDiscusses molecular biology, histopathology, and genomicsPresents rehabilitation for neurological deficits resulting from schwannomas and treatment

Neuropalliative Care, Part Two, Volume 191 covers a type of care that is given when there is no cure for the neurological disorder and the patient is in distress. It provides a scholarly background of neuropalliative care, from historic underpinnings to its practice in various geographical regions, along with best practices for specific neurological disorders. It covers the work of multi or interdisciplinary teams whose care is intended to make the patient as comfortable as possible and includes partners and families in treatment plans. Summarizes research in neuropalliative care Identifies current practices in different geographic regions Provides best practices for specific neurological disorders and patient populations Includes advanced care planning

Neuropalliative Care, Part One, Volume 190 covers a type of care that is given when there is no cure for the neurological disorder and the patient is in distress. It provides a scholarly background of neuropalliative care, from historic underpinnings to its practice in various geographical regions, along with best practices for specific neurological disorders. It covers the work of multi or interdisciplinary teams whose care is intended to make the patient as comfortable as possible and includes partners and families in treatment plans. Summarizes research in neuropalliative care Identifies current practices in different geographic regions Provides best practices for specific neurological disorders and patient populations Includes advanced care planning

Precision Medicine in Neurodegenerative Disorders, Part One, Volume 192 in the Handbook of Clinical Neurology deals with the "Why" in the approach to slow the progression of accelerated brain aging. This volume is intended to provide a scholarly background on the framework, basic science and conceptual pitfalls related to disease-modifying efforts in Parkinson's, Alzheimer's and other neurodegenerative disorders. Among topics covered are different models of precision medicine, the lumping-versus-splitting tension in biomarker development and therapeutics, and the rationale for replacing the convergence of the prevailing autopsy-based nosology of neurodegenerative diseases with the divergence of a systems biology approach to human diseases.

Specific chapters are dedicated to the promise of genetic subtypes and the lessons in disease modification offered by the fields of oncology and cystic fibrosis that can be adapted to the field of neurodegeneration. Matching a biology-correcting therapy with those biologically suitable to benefit from such therapy represents the vision and mission of precision medicine, the highest level of personalized medicine.

Summarizes theory and research on precision medicine in neurodegenerative disorders Covers basic biology, clinical trials and therapeutics Includes disease mechanisms, genetic subtypes, and more