Retinoic Acids in Cancer Therapy: Mechanisms of Sensitivity, Resistance, and Methods of Delivery provides an overview of how All-Trans Retinoic Acid (ATRA) kills cancer cells and how some cells survive treatment. Focusing on the cellular pathways and compartments involved in ATRA-mediated inhibition of proliferation, this book also discusses how aggressive tumors develop escape routes conferring retinoic acid resistance.Across 15 chapters, it describes the molecular structure and biological properties of ATRA, explains mechanisms of resistance, and defines ATRA''s efficacy in seven cancer types. It concludes with chapters on ATRA and cancer stem cell biology, strategies to improve treatment, future therapeutic perspectives, and delivery methods to reduce toxicity and enhance anticancer efficacy.Each chapter includes Learning Objectives and a "What We Learn" section, making the book highly accessible for undergraduate, graduate trainees, scientists, physicians, and biotech companies. Adding simple, attractive schemes and informative tables makes it ideal for all interested in the current status of Retinoic Acids in Cancer Therapy. This book serves as a valuable resource for health professionals, scientists, researchers, clinical practitioners, and all those seeking to broaden their knowledge and develop new drugs or therapeutic strategies to improve ATRA''s efficacy in the treatment of resistant cancers.- Includes Learning Objectives and "What We Learn" sections in every chapter- Presents concise schematic figures illustrating apoptotic and autophagic pathways- Explains the interplay of apoptosis (intrinsic and extrinsic) and autophagy in ATRA-induced cell death- Discusses autophagy targeting to enhance ATRA effectiveness- Examines cancer stem cell fate modulation with ATRA- Highlights future directions and delivery strategies to minimize off-target effects
