Ali Zarrabi – författare

Retinoic Acids in Cancer Therapy: Mechanisms of Sensitivity, Resistance, and Methods of Delivery provides an overview of how All-Trans Retinoic Acid (ATRA) kills cancer cells and how some cells survive treatment. Focusing on the cellular pathways and compartments involved in ATRA-mediated inhibition of proliferation, this book also discusses how aggressive tumors develop escape routes conferring retinoic acid resistance.Across 15 chapters, it describes the molecular structure and biological properties of ATRA, explains mechanisms of resistance, and defines ATRA's efficacy in seven cancer types. It concludes with chapters on ATRA and cancer stem cell biology, strategies to improve treatment, future therapeutic perspectives, and delivery methods to reduce toxicity and enhance anticancer efficacy.Each chapter includes Learning Objectives and a "e;What We Learn"e; section, making the book highly accessible for undergraduate, graduate trainees, scientists, physicians, and biotech companies. Adding simple, attractive schemes and informative tables makes it ideal for all interested in the current status of Retinoic Acids in Cancer Therapy. This book serves as a valuable resource for health professionals, scientists, researchers, clinical practitioners, and all those seeking to broaden their knowledge and develop new drugs or therapeutic strategies to improve ATRA's efficacy in the treatment of resistant cancers. - Includes Learning Objectives and "e;What We Learn"e; sections in every chapter- Presents concise schematic figures illustrating apoptotic and autophagic pathways- Explains the interplay of apoptosis (intrinsic and extrinsic) and autophagy in ATRA-induced cell death- Discusses autophagy targeting to enhance ATRA effectiveness- Examines cancer stem cell fate modulation with ATRA- Highlights future directions and delivery strategies to minimize off-target effects

Retinoic Acids in Cancer Therapy: Mechanisms of Sensitivity, Resistance, and Methods of Delivery provides an overview of how All-Trans Retinoic Acid (ATRA) kills cancer cells and how some cells survive treatment. Focusing on the cellular pathways and compartments involved in ATRA-mediated inhibition of proliferation, this book also discusses how aggressive tumors develop escape routes conferring retinoic acid resistance.Across 15 chapters, it describes the molecular structure and biological properties of ATRA, explains mechanisms of resistance, and defines ATRA’s efficacy in seven cancer types. It concludes with chapters on ATRA and cancer stem cell biology, strategies to improve treatment, future therapeutic perspectives, and delivery methods to reduce toxicity and enhance anticancer efficacy.Each chapter includes Learning Objectives and a “What We Learn” section, making the book highly accessible for undergraduate, graduate trainees, scientists, physicians, and biotech companies. Adding simple, attractive schemes and informative tables makes it ideal for all interested in the current status of Retinoic Acids in Cancer Therapy. This book serves as a valuable resource for health professionals, scientists, researchers, clinical practitioners, and all those seeking to broaden their knowledge and develop new drugs or therapeutic strategies to improve ATRA’s efficacy in the treatment of resistant cancers.

Includes Learning Objectives and “What We Learn” sections in every chapterPresents concise schematic figures illustrating apoptotic and autophagic pathwaysExplains the interplay of apoptosis (intrinsic and extrinsic) and autophagy in ATRA-induced cell deathDiscusses autophagy targeting to enhance ATRA effectivenessExamines cancer stem cell fate modulation with ATRAHighlights future directions and delivery strategies to minimize off-target effects

Nanophytomedicine: Harnessing Phytochemicals for Advanced Therapeutics explores the integration of phytochemicals and nanotechnology to develop advanced therapeutic solutions. The book offers an extensive overview of phytochemicals, explaining their sources, extraction methods, classifications, and applications in medicine. This emerging field aims to utilize the natural properties of phytochemicals to create innovative treatments for various diseases, with a particular focus on hard-to-treat conditions such as cancer. By combining plant-derived compounds with nanomaterials, researchers are unlocking new potential in precision medicine, seeking to enhance the efficacy of treatments while minimizing side effects and improving patient outcomes.In 18 comprehensive chapters, the book delves into the therapeutic properties of phytochemicals, such as their antioxidant, antifungal, and anti-inflammatory effects. It highlights the role of these compounds in combating diseases including cancer, neurological disorders, diabetes, and cardiovascular diseases. The use of nano drug delivery systems is emphasized, showcasing how these technologies can improve the delivery and effectiveness of phytochemicals.Focuses on different sources of phytochemicals, their extraction methods, classifications, and an overview of their application in medicineDescribes the different types of phytochemicals and their different properties with special focus on antioxidant, anti-inflammatory, and antifungal propertiesSummarizes the mechanisms of each type of phytochemical on suppressing the proliferation of cancer cells

This Brief introduces SuperParamagnetic Iron Oxide Nanoparticles (SPIONs), the different synthesis approaches, their applications in the field of diagnostics and treatment and finally as theranostic agents in cancer.