Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders

Alzheimer's Disease

Inbunden, Engelska, 2025

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Beskrivning

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease, Second Edition delves into the complexities of drug discovery, specifically for Alzheimer's Disease, presenting the necessary paradigm for future success in research and treatment. This edition is thoroughly updated with recent developments in therapeutic strategies, including amyloid hypothesis, tau, apo E, insulin, and others, and introduces a new chapter on drug delivery to the brain. Additionally, the book encompasses diagnosis, epidemiology, drug discovery strategies, current therapeutics, and more, offering a comprehensive approach to Alzheimer's Disease.

It covers the latest in targeted drug design, preclinical studies, and animal models, making it an essential resource for pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers. Patients and advocacy groups can also gain valuable insights from the overview of current treatments and scientific advancements in the field.

Covers Monoclonal Antibodies approaches
Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders
Explores how in vitro and in vivo models translate to human physiology

Produktinformation

Utgivningsdatum:2025-11-12
Mått:191 x 235 x 28 mm
Vikt:880 g
Format:Inbunden
Språk:Engelska
Antal sidor:480
Upplaga:2
Förlag:Elsevier Science
ISBN:9780443300080

Utforska kategorier

Farmakologi inom Medicin
Biovetenskap inom Naturvetenskap och teknik
Alzheimer, demens inom Medicin

Mer om författaren

Adeboye Adejare’s research group is interested in the areas of design and syntheses of small organic molecules to probe neurodegeneration, especially Alzheimer’s disease, and for treatment of cancer. They are also interested in in vitro models of drug absorption and ability to cross blood brain barrier; drug targeting; pharmaceutical profiling; and chemistry of fluoroaromatic compounds. The research is funded by the National Institutes of Health, the Office of Naval Research, and several pharmaceutical companies. These efforts have resulted in over 50 publications, 5 patents, and over 100 presentations at meetings, including invited presentations at national and international conferences. He also serves on several national panels, including those by NIH, NSF, and Alzheimer’s Association.Dr. Adejare is the editor of Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease which is also published by Elsevier.

Innehållsförteckning

1. Neurodegenerative disorders: why do we need new therapies?2. Cognitive and functional considerations in Alzheimer’s disease diagnosis3. National plan and resources to address Alzheimer’s disease4. Biosensor approaches in the diagnosis of a neurodegenerative disorder5. Current therapies for the treatment of Alzheimer’s disease: small molecules - Acetylcholine esterase inhibitors and NMDA receptor antagonist6. Physicochemical properties for potential AD drugs7. Receptor targets in Alzheimer’s disease drug discovery8. Amyloid hypothesis in the development of therapeutic agents for Alzheimer’s disease 9: Tau proteins10. Cholesterol and fat metabolism in Alzheimer’s disease11. Mitochondria as a therapeutic target for the treatment of Alzheimer’s disease12. Peptide-based therapeutics13. Anti-inflammatory and immunomodulating agents14. Prion and other protein folding hypotheses15. Simple in vivo models of Alzheimer’s disease16. Rodent models for Alzheimer’s disease drug discovery17. Drug delivery to the brain18. Alzheimer’s disease drugs in clinical trials19. Biologics for the treatment of Alzheimer’s disease20. Brain health21. Non-pharmacologic treatment approaches