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    1. Naturvetenskap och teknik
    2. Matematik och naturvetenskap
    3. Biologi
    4. Biovetenskap

    Neurogenetic Therapies

    Advancements in Treating Nervous System Disorders

    AvAshutosh Pareek,Arun Kumar Singh

    Häftad, Engelska, 2027

    1 917 kr

    Beställningsvara. Skickas inom 11-20 vardagar. Fri frakt över 249 kr.

    Beskrivning

    Neurogenetic Therapies: Advancements in Treating Nervous System Disorders offers a comprehensive resource on the latest gene therapy techniques and their applications in treating neurological disorders. The book delves into various gene therapy methods, including genomic DNA-based therapies, vector-mediated delivery, and RNA interference-based gene silencing. It explores the use of these techniques in treating conditions such as Alzheimer's disease, Parkinson's disease, spinal muscular atrophy, and Duchenne muscular dystrophy. Key topics include the molecular and genetic basis of nervous system disorders, the role of epigenetics, and the development of stem cell and genome editing therapies.

    With contributions from leading experts, the book also addresses regulatory and ethical considerations in gene therapy, providing a balanced perspective on the challenges and opportunities in this rapidly evolving field. Case studies and practical examples illustrate successful gene therapy treatments, offering valuable insights into translating research into clinical practice. This book is an essential resource for students, researchers, and scientists in neurogenetics, neurology, and molecular biology, as well as clinicians interested in the mechanisms and treatment of neurodegenerative diseases.

    • Provides comprehensive coverage of innovative gene therapy techniques for neurological disorders
    • Examines regulatory and ethical considerations in the application of gene therapy
    • Explores emerging gene transfer technologies and their clinical applications
    • Highlights detailed methodologies and experimental approaches for neurogenetic therapies
    • Presents case studies that showcase successful gene therapy treatments for neurodegenerative diseases

    Produktinformation

    • Utgivningsdatum:2027-02-01
    • Mått:191 x 235 x undefined mm
    • Vikt:450 g
    • Format:Häftad
    • Språk:Engelska
    • Antal sidor:375
    • Förlag:Elsevier Science
    • ISBN:9780443405747

    Utforska kategorier

    • Biovetenskap inom Naturvetenskap och teknik

    Mer om författaren

    Ashutosh Pareek is Professor at Banasthali Vidyapith, India, with expertise in neuropharmacology and advanced drug delivery systems. His research focuses on therapeutic strategies for neurodegenerative disorders, cancer, autoimmune diseases, and related health conditions, with particular interest in the development of innovative drug delivery approaches for bioactive and immunomodulatory compounds. Dr. Pareek leads research initiatives in these areas and collaborates with national and international funding agencies on projects that advance pharmaceutical science and translational research. He has contributed extensively to the scientific literature through scholarly publications, books, patents, and research mentorship. In addition, he serves on editorial and peer-review activities for international journals in pharmacology and oncology, supporting the dissemination and evaluation of research across the biomedical sciences. Arun Kumar Singh is an Assistant Professor in the Department of Pharmacy at University School of Pharmaceutical Sciences, Rayat Bahra University V.P.O. Sahauran, India. He completed his M.Pharm in Pharmaceutics from Galgotias University, Greater Noida. His research interests include nano-formulation, blockchain, IoT, machine learning, artificial intelligence, big data analytics, cancer biology, and neuroscience. He has contributed to academic books and book chapters and has published review articles in the areas of pharmaceutical sciences and healthcare technology. His work focuses on interdisciplinary approaches integrating pharmaceutical research with emerging digital and computational technologies. Prof. Anil Chuturgoon is a medical biochemist with a PhD in toxicology and epigenetics. He is a professor and head of medical biochemistry and is currently the dean of research at the College of Health Sciences. He is a B-rated medical scientist by the National Research Foundation of South Africa; he has published over 200 research papers and 12 chapters in books, and he has edited two books and many conference proceedings.He actively researches epigenetic phenomena in toxicology and its implications in human diseases. He is a world expert on mycotoxins and their biological toxicity in humans. He pioneered research on fusariotoxins and epigenetics and their implication in disease. His contribution to Toxicology has been recognised by the CTD curator (NIEHS, USA), where 8 of his manuscripts are included in this database; the database provides manually curated information about chemical–gene/protein interactions, chemical–disease and gene-disease relationships. He has successfully supervised and graduated over 150 Masters and 50 PhD students. He serves as editor of several journals, including Nature: Scientific Reports and Frontiers in Reproductive Health. Dr Aaushi Pareek works as an Assistant Professor at Banasthali Vidyapith, India. Her research focuses on neuropharmacology and developing targeted drug-delivery systems for neurological and inflammatory diseases. As an independent principal investigator, she is deeply committed to advancing the understanding of neurodegenerative diseases through innovative therapeutic approaches. She holds an international formulation patent for developing polyphenol-loaded phytosomes for cancer treatment. She is also a distinguished recipient of international travel grants from the International Society for Neurochemistry (ISN) and the International Brain Research Organization (IBRO). Dr. Bonga Chiliza is an Associate Professor and Head of the Department of Psychiatry at the University of KwaZulu-Natal in Durban, South Africa. He is the Deputy Editor of the South African Journal of Psychiatry and one of the Founding Directors of the Africa Global Mental Health Institute. He completed his medical degree and psychiatry specialization at the University of KwaZulu-Natal and his PhD at Stellenbosch University. His research interests include first-episode psychosis, schizophrenia, psych epidemiology and health services research and medical education. Prof Chiliza has received several awards from South African institutions and research grants from international funding agencies. He has published more than 120 peer-reviewed articles and book chapters. He has also led a number of not-for-profit boards, including the South African YMCA, the South African Society of Psychiatrists, and Harambee Medical Consulting.

    Innehållsförteckning

    • 1. Molecular and Genetic Basis of Nervous System Disorders2. Systems Biology Approaches in the Diagnosis of Neurological Disorders3. Approaches for Gene Therapy and Its Possible Uses in Neurological Disorders4. Genomic DNA-Based Gene Therapy: Recent Developments and Future Directions5. Vector-Mediated Delivery of Transgenes and RNA Interference-Based Gene Silencing Sequences to Oligodendrocytes6. Gene Transfer to Spinal Cord Neurons and Glial Cells through Adeno-Associated Virus Vector7. Gene Therapy Models8. Case Studies Based on Gene Therapies in Treating Neurological Disorders9. Viral Gene Therapy Targets Astrocytes for Alzheimer's Disease10. Lentiviral Gene Delivery of Orexin to Study Its Role in Alzheimer's Disease11. Neurotrophin Gene Therapy for Parkinson's Disease Under Pharmacological Regulation12. An Emerging Target for Parkinson's Disease Symptom and Medication Management: p11 Gene Therapy13. Application of Gene Therapy Employing Stem Cells to Treat Neurological Disorders14. Developing Human-Induced Pluripotent Stem Cells into Purkinje Neurons15. Utilizing Herpes Simplex Virus Mutants as a Therapeutic Intervention for Neurogenic Pain16. A Synopsis of Preclinical and Clinical Trials Concerning Immunotherapy Virotherapy for Astrocytoma17. Nanoparticles in the Treatment of Neurological Disorders18. Success Rates / Failures of Gene Therapy Techniques
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