The Ovary

Dr. Leung is a Professor at the University of British Columbia’s Department of Obstetrics & Gynecology and former Associate Dean in the Faculty of Medicine at UBC. Dr. Leung received his PhD from Western University. After post-doctoral training at the University of California at Los Angeles and the Laval University, he joined the University of British Columbia in 1982 as a faculty member. Dr. Leung has received a number of prestigious awards, including a Scholar Award and a Scientist Award from the Medical Research Council of Canada, a Distinguished Scholar Award from the Michael Smith Foundation for Health Research and a Senior Scientist Award from the BC Children Hospital Research Institute. Dr. Leung has served on many national and international organizations, including as President of the Canadian Fertility and Andrology Society, Director of the Society for the Study of Reproduction, Director of the Ovarian Workshops in the USA, temporary advisor to the World Health Organization, Fellow of the Canadian Academy for Health Sciences, and Fellow of the Royal Society of Canada. Dr. Leung’s research focuses on hormonal determinants of women’s reproductive health. His publication record to date includes 400 papers, 350 abstracts, 22 book chapters and 7 monographs. Since his appointment at UBC, Dr. Leung has served as the research supervisor for more than 100 graduate students, postdoctoral fellows and visiting scientists. Dr. Jie Qiao is the Chief Scientist of the Ministry of Science and Technology of China, the Incumbent Director of the North Third Hospital Department of Obstetrics and Gynecology, the Chinese Medical Association branch chairman for Reproductive Medicine, and the Beijing Medical Association branch chairman for Reproductive Medicine. She has been engaged in reproductive health-related clinical and basic research throughout her career, including as a visiting scholar at the University of Hong Kong and as a post-doctoral researcher at Stanford University. Her research has focused on gametes fertilization, infertility and embryo implantation mechanisms, and polycystic ovary syndrome pathogenesis among other topics. Dr. Jie Qiao has published more than 250 paper publications in peer reviewed journals on topics related to reproductive health. Dr. Alan B. Adashi is a prominent academic physician-executive and former Dean of Medicine and Biological Sciences at Brown University during its 2007 renaming. He earned his medical degree from the Sackler School of Medicine in 1973, completed residency in Obstetrics and Gynecology at Tufts University, and fellowship training in Reproductive Endocrinology and reproductive biology at Johns Hopkins and UC San Diego. He holds an MS in Health Care Management from Harvard T.H. Chan School of Public Health. Dr. Adashi served on faculty at the University of Maryland, University of Utah—where he chaired Obstetrics and Gynecology and founded the Ovarian Cancer Program—and Brown University. He is a former president of the Society for Reproductive Endocrinologists, Society for Gynecologic Investigation, and American Gynecological and Obstetrical Society. With nearly 400 publications and over 50 mentored postdoctoral trainees, his work has been widely recognized and featured in major media outlets.

• Part I1. Cellular Atlas of the Human Ovary2. Differentiation Trajectory of Theca/Stroma Cells3. Germline-soma Interactions in Oocyte Growth4. Organization of Ovarian Steroidogenic Cells and Cholesterol Metabolism5. Follicle Selection in Mammalian Ovaries6. Regulation of Follicle Formation and Development by Ovarian Signaling Pathways7. Development of the Mammalian Ovary and Follicles8. Activin, Inhibin, and Follistatin in Ovarian Physiology9. Cell-cell Interactions in the Ovarian Follicle10. Mutations and Polymorphisms, and Their Functional Consequences, in Gonadotropin and Gonadotropin Receptor Genes11. Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian DiseasePart II12. Mammalian Oogenesis: The Fragile Foundation of the Next Generation13. Regulation of Mammalian Oocyte Maturation14. Oocyte Meiotic Maturation15. Gene Expression During Oogenesis and Oocyte Development16. Ovulation: The Coordination of Intrafollicular Networks to Ensure Oocyte ReleasePart III17. Molecular Regulation of Progesterone Production in Corpus Luteum18. Corpus Luteum Formation19. Luteolysis and The Corpus Luteum of PregnancyPart IV20. In Vitro Gametogenesis21. Ovary-on-a-Chip Models22. Transgenic Models to Study Ovarian Function23. Genome-Wide Association Studies of Ovarian Function Disorders24. Mitochondria Research in Human Reproduction25. The Role of Mitochondria in Reproductive Function and Assisted Reproduction26. Oocyte-mediated Intergenerational Transmission of Chronic Diseases28. Human Ovarian Aging: Insights from Single-nuclei Multi-omics Analyses29. Application of Artificial Intelligence in Assisted Reproductive TechnologiesPart V30. Ovarian Hyperstimulation Syndrome31. The Role of GnRH Agonist Trigger in GnRH Antagonist-Based Ovarian Hyperstimulation Protocols 32. The Ovarian Factor in Assisted Reproductive Technology33. The Role of Anti-Müllerian Hormone in Assisted Reproduction34. Polycystic Ovary Syndrome35. Genetic and Environmental Factors in the Etiology of Polycystic Ovary Syndrome36. Germ Cell Failure and Ovarian Resistance: Human Genes and Disorders37. Environmental Contaminants and Ovarian Toxicity38. Autologous Transplantation of Human Ovarian Tissue39. Fertility Preservation40. Oncofertility: Preservation of Ovarian Function After a Cancer Diagnosis41. Implications of Recent Breakthroughs and Innovations on the Future of In Vitro FertilizationPart VI42. Cellular Origins of Ovarian Cancer43. Phenotypic Plasticity and the Origins and Progression of Ovarian Cancer44. Novel Therapeutic Approaches and Targets for Ovarian Cancer45. Chemoresistance in Ovarian Cancer: Integrating Single-Cell Transcriptomics with Targeted Proteomics46. Artificial Intelligence Liquid Biopsy Approaches for Early Detection and Monitoring of Cancer Patients47. Artificial Intelligence in Reproductive Medicine: Legal and Ethical Implications