Protein Repair Mechanisms in Alzheimer's Disease

Protein Repair Mechanisms in Alzheimer’s Disease: Molecular Pathways and Therapeutic Frontiers offers a detailed examination of the molecular processes that maintain neuronal proteostasis and how their disruption contributes to Alzheimer’s disease progression.

The book is structured into five sections, beginning with foundational concepts including protein quality control, age-related proteostasis decline, heat-shock response, chaperone networks, and endoplasmic reticulum stress. Focus then turns to the cellular mechanisms responsible for protein degradation and clearance, including the ubiquitin-proteasome system, autophagy-lysosome axis, mitochondrial quality control, and extracellular proteostasis. The book also explores key molecular modulators of protein repair, such as disaggregases, isomerases, kinases, and tau protein. It then considers cellular and systemic perspectives, highlighting the roles of glial cells and synaptic proteostasis in neurodegeneration. The final section examines translational insights and emerging therapeutic applications, including novel biomarkers, autophagy enhancers, proteolysis-targeting chimeras (PROTACs), and gene-editing techniques. Combination therapies and multi-omics approaches are also covered, with a look towards future possibilities and challenges that need to be tackled in translating these advances into clinical practice.

By addressing the complex interplay of protein repair systems and neurodegeneration, this reference delivers a mechanistic understanding of Alzheimer’s disease, bridging fundamental molecular science with translational medicine. It serves as an invaluable resource for researchers, students and clinicians seeking insights into how these mechanisms can be harnessed to develop targeted treatments that slow or mitigate neurodegenerative disease progression.

• Explores protein repair pathways and their relevance to Alzheimer’s disease
• Investigates molecular mechanisms responsible for maintaining protein integrity, and how their dysfunction contributes to amyloid and tau pathology
• Highlights innovative treatment strategies including novel biomarkers and gene editing
• Delivers a multidisciplinary approach, integrating insights from molecular biology, neuroscience, pharmacology and translational medicine