Methods of Therapeutic Drug Monitoring Including Pharmacogenetics

AvGeorg Hempel,Westfalische Wilhelms-Universitat Munster) Hempel, Georg (Institut fur Pharmazeutische und Medizinische Chemie

Häftad, Engelska, 2019

Del 7 i serien Handbook of Analytical Separations

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Beskrivning

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs.

Presents a unique, interdisciplinary approach that appeals to a wide range of users
Written by authors from international labs, providing a global perspective that can be applied in various regulatory environments
Features additional therapeutic drugs to reflect the rising number of immunocompromised patients
Includes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories

Produktinformation

Utgivningsdatum:2019-10-18
Mått:191 x 235 x undefined mm
Vikt:840 g
Format:Häftad
Språk:Engelska
Serie:Handbook of Analytical Separations
Antal sidor:380
Upplaga:2
Förlag:Elsevier Science
ISBN:9780444640666

Utforska kategorier

Biokemi inom Naturvetenskap och teknik
Farmakologi inom Medicin

Mer om författaren

Georg Hempel is a pharmacist who did his Ph.D. with Gottfried Blaschke in Münster on chiral separations using HPLC and capillary electrophoresis. He worked as a laboratory supervisor in the paediatric oncology department of the University Hospital of Münster. During his postdoc with Eli Lily and Company Ltd. in the United Kingdom, he became involved in pharmacokinetics. Since 1999, he has been working at the Department of Pharmaceutical and Medical Chemistry at the University of Münster, where he established a Clinical Pharmacy research group.His research interests include bioanalytical methods for the quantification of drugs in biological fluids, especially capillary electrophoresis, pharmacometrics for therapy optimisation in special patient groups and medication management.

Innehållsförteckning

1. Sample Preparation for the Analysis of Drugs in Biological Fluids2. Chromatograpghic Methods for the Analysis of Drugs in Biological Fluids3. Mass Spectrometry for the Quantification of Drugs in Biological Fluids4. Capillary Electrophoresis for the Determination of Drugs in Biological Fluids5. Immunoassays for the Determination of Drugs in Biological Fluids6. Validation of Bioanalytical Methods for the Quantification od Drugs in Biological Fluids7.Pharmocokinetic Methods for the Analysis, Interpretation, and Management of TDM Data for Individualising Drug Dosage Regimens Optimally 8. Therapeutic Drug Monitoring of Antibiotics in Critically Ill Patients9. Therapeutic Drug Monitoring of Antifungals10. Therapeutic Drug Monitoring of Antiepileptic Drugs11. Therapeutic Drug Monitoring Antipsychotic and Antidepressant Drugs12. Monitoring Immunosuppressant Drugs13. Dose and Therapy Individualisation in Cancer Chemotherapy14. Pharmacogenomics