Methods of Therapeutic Drug Monitoring Including Pharmacogenetics

Georg Hempel is a pharmacist who did his Ph.D. with Gottfried Blaschke in Münster on chiral separations using HPLC and capillary electrophoresis. He worked as a laboratory supervisor in the paediatric oncology department of the University Hospital of Münster. During his postdoc with Eli Lily and Company Ltd. in the United Kingdom, he became involved in pharmacokinetics. Since 1999, he has been working at the Department of Pharmaceutical and Medical Chemistry at the University of Münster, where he established a Clinical Pharmacy research group.His research interests include bioanalytical methods for the quantification of drugs in biological fluids, especially capillary electrophoresis, pharmacometrics for therapy optimisation in special patient groups and medication management.

• 1. Sample Preparation for the Analysis of Drugs in Biological Fluids2. Chromatograpghic Methods for the Analysis of Drugs in Biological Fluids3. Mass Spectrometry for the Quantification of Drugs in Biological Fluids4. Capillary Electrophoresis for the Determination of Drugs in Biological Fluids5. Immunoassays for the Determination of Drugs in Biological Fluids6. Validation of Bioanalytical Methods for the Quantification od Drugs in Biological Fluids7.Pharmocokinetic Methods for the Analysis, Interpretation, and Management of TDM Data for Individualising Drug Dosage Regimens Optimally 8. Therapeutic Drug Monitoring of Antibiotics in Critically Ill Patients9. Therapeutic Drug Monitoring of Antifungals10. Therapeutic Drug Monitoring of Antiepileptic Drugs11. Therapeutic Drug Monitoring Antipsychotic and Antidepressant Drugs12. Monitoring Immunosuppressant Drugs13. Dose and Therapy Individualisation in Cancer Chemotherapy14. Pharmacogenomics