Separation Methods in Drug Synthesis and Purification

Dr. Klára Valkó is an enthusiastic principal scientist and consultant supporting early drug discovery and lead optimization with over 22 years of experience. She has been an Honorary Professor at UCL School of Pharmacy since 2004, leading the Physchem/ADME module (London, UK) for Drug Discovery MSc. Her many contributions to the field include the development of biomimetic HPLC methods for high throughput measurements of serum albumin, glycoprotein and phospholipid binding, the invention of the Chromatographic Hydrophobicity Index for fast determination of compounds’ lipophilicity using generic gradient reversed phase chromatography, and more.

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• PrefaceKlara Valko1. Comparison of various modes and phase systems for analytical HPLCPavel Jandera2. Fast-generic HPLC methods Ian M. Mutton3. Advances in capillary electrochromatographyJosé Luís Dores-Sousa, Jelle De Vos, Debby Mangelings and Sebastiaan Eeltink4. Coupled chromatographyemass spectrometry techniques for the analysis of combinatorial librariesSteve Lane5. Experimental design-based optimization strategies for chromatographic and capillary electrophoretic separationsJ. Viaene and Y. Vander Heyden6. Computer-aided HPLC method development for quality control of complex drug mixtures--An application example for DryLabHalina Katsialevich, Hans-Jürgen Rieger, Imre Molnár and Arnold Zöldhegyi7. The flexible application of automated preparative purification platforms within drug discoveryJennifer Kingston, Neil Sumner, Katie Proctor and Elisabetta Chiarparin8. Strategies for the development of process chromatography as a unit operation for the pharmaceutical industryDrew Katti9. Recent developments in liquid and supercritical fluid chromatographic enantioseparationsDebby Mangelings, Sebastiaan Eeltink and Yvan Vander Heyden10. Basis and pharmaceutical applications of thin-layer chromatographyHuba Kalász, Mária Báthori and Klára Valko11. Recent advances in quantitative structureeretention relationshipsRoman Kaliszan12. Capillary electrophoresis for drug analysis and physicochemical characterizationSusana Amézqueta, Xavier Subirats, Elisabet Fuguet, Clara Ràfols and Martí Rosés13. Application of HPLC measurements for the determination of physicochemical and biomimetic properties to model in vivo drug distribution in support of early drug discoveryKlára L. Valkó