In Volume 18 of this well-established series, Professor Atta-ur-Rahman again brings together the work of several of the world's leading authorities in organic chemistry. Their contributions demonstrate the rapid, ongoing development of this field by illustrating many of the latest advances in synthetic methods, total synthesis, structure determination, biosynthetic pathways, and biological activity.The opening chapter presents an overview of strategies for the synthesis of several classes of natural products with an emphasis on complex polycyclic systems. Subsequent chapters discuss the synthesis of specific classes of compounds, including morphine, polyketides, acetogenins, nonactic acid derivatives, complex spirocyclic ethers, �-lactam and pyridone derivatives, inositol phosphates, sphingolipids, brassinosteroids, Hernandia lignans, and dimeric steroidal pyrazine alkaloids. Finally, the ever stronger links between chemistry and biology are reinforced by chapters on the origin and function of secondary metabolites, bioactive conformations of gastrin hormones, and immunochemistry.

Produktinformation

Utgivningsdatum:1996-05-01
Mått:175 x 245 x 0 mm
Vikt:1 810 g
Format:Inbunden
Språk:Engelska
Serie:Studies in Natural Products Chemistry
Antal sidor:1 116
Förlag:Elsevier Science
ISBN:9780444824585

Utforska kategorier

Biokemi inom Naturvetenskap och teknik
Biologi inom Naturvetenskap och teknik
Organisk kemi inom Naturvetenskap och teknik

Mer om författaren

Atta-ur-Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, was the Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. He is a leading scientist with more than 1283 publications in several fields of organic chemistry.

Innehållsförteckning

Strategies for the Stereocontrolled De Novo Synthesis of Natural Prdoucts (L.A. Paquette). A Historical Perspective of Morphine Synthesis (T. Hudlicky et al. ). New Developments in the Synthesis of Polyketides and of Chiral Methyl Groups (J. Mulzer). Total Stereoselective Synthesis of Acetogenins of Annonaceae: A New Class of Bioactive Polyketides (B. Figadere, A. Cave). The Synthesis of Nonactic Acid. Its Derviatives and Nonactin itself (I. Fleming, S.K. Ghosh). Total Synthesis of Bioactive Natural Spiroethers, Tautomycin and Oscillatoxin D (A. Ichihara et al. ). Aza-Annulation of Enamine Related Substrates with alpha,beta-Unsaturated Carboxylate Derivatives as a Route to the Selective Synthesis of delta-Lactams and Pyridones (J.R. Stille, N.S. Barta). Selective Reactions and Total Synthesis of Inositol Phosphates (Y. Watanabe). Synthesis of Phytosphingolipids (T. Kamikawa). New Developments in Brassinosteroid Research (G. Adam et al. ). Structure Elucidation and Synthesis of the Lignans from the Seeds of Hernandia ovigera L. (M. Arimoto et al. ). Studies on the Absolute Configuration of Some Liverwort Sesquiterpenoids (M. Tori). Bioactive Gymnemic Acids and Congeners from Gymnema sylvestre (S.B. Mahato). Theory of the Origin, Function, and Evolution Secondary Metabolites (C. Christophersen). The Celastraceae from Latin America Chemistry and Biological Activity (O. Munoz et al. ). Structural Chemistry of Glycolipids from Fungi and Protozoa (E.B. Bergter, M.H.S.V. Boas). Potential Bioactive Conformations of Hormones of the Gastrin Family (L. Moroder, J. Lutz). When Two Steroids are Better than One: The Dimeric Steroid-Pyrazine Marine Alkaloids (A. Ganesan). Human IgG1 Hinge-Fragment as a Core Structure for Immunogens (L. Moroder et al. ). 13 C-NMR Spectroscopy of Coumarins and their Derivatives: A Comprehensive Review (B. Mikhova, H. Duddeck).