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    1. Naturvetenskap och teknik
    2. Matematik och naturvetenskap
    3. Biologi
    4. Biokemi

    Radical and Radical Ion Reactivity in Nucleic Acid Chemistry

    AvMichael D. Greenberg

    Inbunden, Engelska, 2009

    Del 5 i serien Wiley Series of Reactive Intermediates in Chemistry and Biology

    1 939 kr

    Beställningsvara. Skickas inom 11-20 vardagar. Fri frakt över 249 kr.

    Beskrivning

    Comprehensive coverage of radical reactive intermediates in nucleic acid chemistry and biochemistry The Wiley Series on Reactive Intermediates in Chemistry and Biology investigates reactive intermediates from the broadest possible range of disciplines. The contributions in each volume offer readers fresh insights into the latest findings, emerging applications, and ongoing research in the field from a diverse perspective.The chemistry and biochemistry of reactive intermediates is central to organic chemistry and biochemistry, and underlies a significant portion of modern synthetic chemistry. Radical and Radical Ion Reactivity in Nucleic Acid Chemistry provides the only comprehensive review of the chemistry and biochemistry of nucleic acid radical intermediates.With contributions by world leaders in the field, the text covers a broad range of topics, including: A discussion of the relevant theoryIonization of DNANucleic acid sugar radicalsHalopyrimidinesOxidative, reductive, and low energy electron transferElectron affinity sensitizersPhotochemical generative of reactive oxygen speciesReactive nitrogen speciesEnediyne rearrangementsPhenoxyl radicalsA unique compilation on the cutting edge of our understanding, Radical and Radical Ion Reactivity in Nucleic Acid Chemistry provides an unparalleled resource to student and professional researchers in such fields as organic chemistry, biochemistry, molecular biology, and physical chemistry, as well as the industries associated with these disciplines.

    Produktinformation

    • Utgivningsdatum:2009-10-23
    • Mått:163 x 244 x 28 mm
    • Vikt:776 g
    • Format:Inbunden
    • Språk:Engelska
    • Serie:Wiley Series of Reactive Intermediates in Chemistry and Biology
    • Antal sidor:480
    • Förlag:John Wiley & Sons Inc
    • ISBN:9780470255582

    Utforska kategorier

    • Biokemi inom Naturvetenskap och teknik
    • Kemi inom Naturvetenskap och teknik

    Mer om författaren

    Marc M. Greenberg is a Professor of Chemistry and Director of the Chemistry Biology Interface Graduate Training Program at Johns Hopkins University. His research uses chemistry, biochemistry, and biology to fundamentally understand how DNA is oxidatively damaged, and what the effects of that damage are. Steven E. Rokita, PhD, is Professor in the Department of Chemistry and Biochemistry at the University of Maryland. His research interests lie in sequence and conformation specific reactions of nucleic acids, enzyme-mediated activation of substrates and coenzymes, halogenation and dehalogenation reactions in biology, aromatic substitution and quinone methide generation in bioorganic chemistry, and copper- and nickel-mediated reactions in bioinorganic chemistry.

    Recensioner i media

    "Scientists who like to understand life sciences at a molecular level will use these reviews for at least the next 10 years." (Angewandte Chemie, 2010) "This is a valuable publication and is a worthwhile addition to the library of any researcher who has an interest in any one (or more) of the subtopics discussed."  (JACS, 2010)

    Innehållsförteckning

    • Preface to Series viiIntroduction ixContributors xi1. Theoretical Modeling of Radiation-Induced DNA Damage 1Anil Kumar and Michael D. Sevilla2. Radical Reaction Pathways Initiated by Direct Energy Deposition in DNA by Ionizing Radiation 41William A. Bernhard3. Chemical Reactions of the Radical Cations of Nucleobases in Isolated and Cellular DNA. Formation of Single-Base Lesions 69Jean Cadet, Thierry Douki, Didier Gasparutto, Jean-Luc Ravanat, and J. Richard Wagner4. Reactivity of Nucleic Acid Sugar Radicals 99Chryssostomos Chatgilialoglu5. Pyrimidine Nucleobase Radical Reactivity 135Marc M. Greenberg6. Reactivity of 5-Halopyrimidines in Nucleic Acids 163Ryu Tashiro and Hiroshi Sugiyama7. Kinetics of Long-Range Oxidative Electron Transfer Through DNA 191Kiyohiko Kawai and Tetsuro Majima8. Radical Intermediates During Reductive Electron Transfer Through DNA 211Reji Varghese and Hans-Achim Wagenknecht9. Low-Energy Electron Interaction with DNA: Bond Dissociation and Formation of Transient Anions, Radicals, and Radical Anions 239Leon Sanche10. Electronic-Affinic Radiosensitizers 295Peter Wardman11. Reactions of Reactive Nitrogen Species and Carbonate Radical Anions with DNA 325Vladimir Shafirovich, Conor Crean, and Nicholas E. Geacintov12. Principles and Applications of Electrochemical Oxidation of Nucleic Acids 357H. Holden Thorp and Julie M. Sullivan13. DNA Damage Due to Diradical-Generating Cyclizations 389Sean M. Kerwin14. DNA Damage by Phenoxyl Radicals 421Richard A. MandervilleIndex 445