Galectins

AvAnatole A. Klyosov,Zbigniew J. Witczak

Inbunden, Engelska, 2008

1 789 kr

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Beskrivning

The comprehensive guide to the current understanding of galectins and their promising potential in drug designThis is the first book focusing on galectins. It was inspired by topics discussed at the symposium "Galectins: Structures, Functions, and Therapeutic Targets" that was a part of the 234th American Chemical Society meeting in 2007. To help chemists, biochemists, and others understand the challenges inherent in the study of galectins and build on recent advances in the field, the editors have compiled articles from leading experts on galectins and their biomedical applications. Galectins includes: An overview of early galectin researchAn explanation of the nature of galectinsA discussion of the structure and functions of galectins, their ligand specificity and molecular mechanisms of action, and the localization of galectins in the cellAn exploration of the roles galectins play in tumor growth and cancer, fibrosis, inflammation, and immunityA discussion of the effect of galectins on cell migration, angiogenesis, and chemoresistanceAn introduction to new approaches to designing galectin inhibitorsThis is the premier reference on galectins for organic, medicinal, carbohydrate, and pharmaceutical chemists, biochemists, molecular and cell biologists, pharmacologists, cancer researchers, and graduate-level students in these disciplines, as well as clinicians and drug developers.

Produktinformation

Utgivningsdatum:2008-08-01
Mått:163 x 243 x 25 mm
Vikt:644 g
Format:Inbunden
Språk:Engelska
Antal sidor:300
Förlag:John Wiley & Sons Inc
ISBN:9780470373187

Utforska kategorier

Biokemi inom Naturvetenskap och teknik

Mer om författaren

Anatole A. Klyosov, PhD, is Chief Scientist and cofounder of Pro-Pharmaceuticals, Inc. He has published more than 290 peer-reviewed articles in scientific journals; authored and edited books on enzymes, carbohydrates, and biotechnology, including Wood-Plastic Composites (Wiley); and holds thirty-nine patents.Zbigniew J. Witczak, PhD, has extensive industrial and academic experience in carbohydrates. He has published more than ninety research papers and holds six patents in the fields of carbohydrate, medicinal, and biological chemistry. In 2000, Dr. Witczak was awarded the Melville L. Wolfrom Award of the ACS Division of Carbohydrate Chemistry for his outstanding research contribution to carbohydrate chemistry and service to the division.David Platt, PhD, is Chief Executive Officer and cofounder of Pro-Pharmaceuticals, Inc. He has published peer-reviewed articles and holds many patents, primarily in the field of carbohydrate chemistry. Dr. Klyosov, Dr. Witczak, and Dr. Platt coedited the ACS symposium book Carbohydrate Drug Design.

Recensioner i media

"The book is the first galectin book and contains a wealth of information … .The chapters provide researchers with a solid overview of the state of the art in the various subjects and will be useful to many galectin researchers." (ChemBioChem, January 2009) "A comprehensive guide to the current understanding of galectins, their promising potential in drug design." (Forbes, June 2008)

Innehållsförteckning

Preface viiContributors ix1 Stumbling on Galectins 1Samuel H. Barondes2 Galectins and Their Functions in Plain Language 9Anatole A. Klyosov3 Understanding Galectin Structure–Function Relationships to Design Effective Antagonists 33Irina V. Nesmelova, Ruud P.M. Dings, and Kevin H. Mayo4 Galectins as Regulators of Tumor Growth and Invasion by Targeting Distinct Cell Surface Glycans and Implications for Drug Design 71Hans-Joachim Gabius and Albert M. Wu5 Nuclear and Cytoplasmic Localization of Galectin-1 and Galectin-3 and Their Roles in Pre-mRNA Splicing 87John L. Wang, Kevin C. Haudek, Patricia G. Voss, and Ronald J. Patterson6 Galectins in Regulation of Inflammation and Immunity 97Fu-Tong Liu, Daniel K. Hsu, Ri-Yao Yang, Huan-Yuan Chen, and Jun Saegusa7 Galectins as Danger Signals in Host–Pathogen and Host–Tumor Interactions: New Members of the Growing Group of "Alarmins"? 115Sachiko Sato and Gabriel A. Rabinovich8 The Role of Galectins in Organ Fibrosis 147Neil C. Henderson and Tariq Sethi9 Galectin-1, Cancer Cell Migration, Angiogenesis, and Chemoresistance 157Florence Lefranc, Marie Le Mercier, Ve´ronique Mathieu, and Robert Kiss10 Galectin-3 in the Progression and Metastasis of Colorectal Neoplasia 193James C. Byrd and Robert S. Bresalier11 Galectins in Malignant Gliomas: Expression, Functions, and Possible Therapeutic Options 223Herwig M. Strik and Anna Hoffmann12 Food-Related Carbohydrate Ligands for Galectins 235Valeri V. Mossine, Vladislav V. Glinsky, and Thomas P. MawhinneyIndex 271