Lisa A. Beltz, PhD, is assistant professor, Department of Biological Sciences, Kent State University at Tuscarawas, New Philadelphia, Ohio. Previously she was associate professor, Department of Biology, University of Northern Iowa, Cedar Falls, Iowa. Among her honors are a post-doctoral trainee fellowship at Johns Hopkins University and a SHARP Research Fellowship at the University of Pittsburgh. She won University of Northern Iowa's Biology Honors Teacher of the Year award in 2005.

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• Tables and Figures viiPreface xvThe Author xviiAcknowledgments xviiiPart 1: Introduction to Emerging Infectious DiseasesChapter 1: Infectious Diseases Past and Present 3Major Concepts 4 • History of Infectious Diseases 5 • The Role of Infectious Diseases in the World Today 8 • The Links Between Infectious Diseases, Poverty, and Civil Unrest 10 • Emerging and Reemerging Infectious Diseases 12 • Factors Contributing to the Emergence of New Infectious Diseases and the Spread and Evolution of Older Diseases 15 • Timeline 18Chapter 2: Of Microbes and Men 27Major Concepts 28 • Introduction 30 • Infectious Agents: The Enemy Combatants 30 • Genetic Information and the Making of Proteins: Preparing the Armament 36 • The Immune Response: Humans Fight Back, Part One 40 • Antimicrobial Agents: Humans Fight Back, Part Two 46Part 2: Bacterial InfectionsChapter 3: Lyme Disease 55Major Concepts 56 • Introduction 58 • History 60 • The Disease 61 • The Causative Agent 63 • The Immune Response 66 • Diagnosis 67 • Treatment 68 • Prevention 69 • Surveillance 71Chapter 4: Human Ehrlichiosis 75Major Concepts 76 • Introduction 77 • History 78 • The Diseases 79 • The Causative Agents 88 • The Immune Response 89 • Diagnosis 90 • Treatment 91 • Prevention 92 • Surveillance 92Chapter 5: Bartonella Infections 97Major Concepts 98 • Introduction 99 • History 99 • The Diseases 101 • The Causative Agents 106 • The Immune Response 109 • Diagnosis 110 • Treatment 111 • Prevention 111 • Surveillance 112Chapter 6: Group A Streptococci 117Major Concepts 118 • Introduction 119 • History 120 • The Diseases 121 • The Causative Agents 127 • The Immune Response 131 • Diagnosis 132 • Treatment 133 • Prevention 134 • Surveillance 135Chapter 7: Escherichia coli O157:H7 139Major Concepts 140 • Introduction 141 • History 142 • The Diseases 143 • The Causative Agents 145 • The Immune Response 151 • Diagnosis 152 • Treatment 153 • Prevention 153 • Surveillance 155Chapter 8: Helicobacter pylori, Ulcers, and Cancer 161Major Concepts 162 • Introduction 163 • History 164 • The Diseases 165 • The Causative Agent 168 • The Immune Response 171 • Diagnosis 172 • Treatment 173 • Prevention 174 • Surveillance 175Chapter 9: Legionnaires’ Disease and Pontiac Fever 181Major Concepts 182 • Introduction 183 • History 184 • The Diseases 185 • The Causative Agent 186 • The Immune Response 191 • Diagnosis 194 • Treatment 197 • Prevention 197 • Surveillance 199Chapter 10: Pulmonary Tuberculosis and Multidrug Resistance 205Major Concepts 206 • Introduction 207 • History 208 • The Disease 209 • The Causative Agents 212 • The Immune Response 213 • Detection and Diagnosis 214 • Treatment and Drug Resistance 216 • Prevention 219 • Surveillance 220Chapter 11: Emerging Bacterial Drug Resistance 225Major Concepts 226 • Introduction 227 • History 228 • The Diseases, Causative Agents, and Treatment Options 229 • Mechanisms of Resistance 235 • Diagnosis 239 • Prevention 240 • Surveillance 240Part 3: Viral InfectionsChapter 12: Marburg and Ebola Hemorrhagic Fevers 247Major Concepts 248 • Introduction 249 • History 250 • The Diseases 254 • The Causative Agents 257 • The Immune Response 262 • Diagnosis 263 • Treatment 264 • Prevention 264 • Surveillance 267Chapter 13: American Hemorrhagic Fevers 273Major Concepts 274 • Introduction 275 • History 277 • The Diseases 278 • The Causative Agents 282 • The Immune Response 285 • Diagnosis 286 • Treatment 287 • Prevention 287 • Surveillance 288Chapter 14: Lassa Hemorrhagic Fever 293Major Concepts 294 • Introduction 295 • History 296 • The Disease 298 • The Causative Agent 300 • The Immune Response 303 • Diagnosis 304 • Treatment 304 • Prevention 306 • Surveillance 308Chapter 15: Dengue Fever and Dengue Hemorrhagic Fever 313Major Concepts 314 • Introduction 315 • History 316 • The Diseases 318 • The Causative Agent 321 • The Immune Response 324 • Diagnosis 327 • Treatment 327 • Prevention 328 • Surveillance 329Chapter 16: The Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome 335Major Concepts 336 • Introduction 338 • History 339 • The Diseases 341 • The Causative Agent 344 • The Immune Response 350 • Diagnosis and Detection 355 • Treatment 355 • Prevention 357 • Surveillance 358Chapter 17: Human Herpesvirus 8 and Kaposi’s Sarcoma 365Major Concepts 366 • Introduction 367 • History 368 • The Diseases 368 • The Causative Agent 373 • The Immune Response 378 • Diagnosis 379 • Treatment 380 • Prevention 383 • Surveillance 383Chapter 18: Hepatitis C 389Major Concepts 390 • Introduction 391 • History 392 • The Diseases 392 • The Causative Agent 397 • The Immune Response 399 • Diagnosis 401 • Treatment 402 • Prevention 403 • Surveillance 404Chapter 19: Epidemic and Pandemic Influenza 409Major Concepts 410 • Introduction 411 • History 412 • The Disease 414 • The Causative Agent 415 • The Immune Response 421 • Diagnosis 421 • Treatment 422 • Prevention 422 • Surveillance 425Chapter 20: Hantavirus Pulmonary Syndrome 431Major Concepts 432 • Introduction 433 • History 435 • The Diseases 435 • The Causative Agents 439 • The Immune Response 444 • Diagnosis 445 • Treatment 446 • Prevention 447 • Surveillance 450Chapter 21: Severe Acute Respiratory Syndrome 455Major Concepts 456 • Introduction 457 • History 457 • The Disease 460 • The Causative Agent 461 • The Immune Response 464 • Diagnosis 465 • Treatment 466 • Prevention 467 • Surveillance 469Chapter 22: West Nile Disease in the United States 475Major Concepts 476 • Introduction 477 • History 477 • The Diseases 481 • The Causative Agent 484 • The Immune Response 487 • Diagnosis 488 • Treatment 489 • Prevention 490 • Surveillance 493Chapter 23: Monkeypox 499Major Concepts 500 • Introduction 501 • History 502 • The Disease 505 • The Causative Agent 508 • The Immune Response 511 • Diagnosis 513 • Treatment 514 • Prevention 514 • Surveillance 516Part 4: Parasitic InfectionsChapter 24: Malaria: Reemergence and Recent Successes 523Major Concepts 524 • Introduction 526 • History 526 • The Disease 528 • The Causative Agents 529 • The Immune Response 533 • Diagnosis 535 • Treatment and Drug Resistance 535 • Prevention: Failures and Successes 537 • Surveillance 541Chapter 25: Babesiosis 547Major Concepts 548 • Introduction 549 • History 549 • The Disease 550• The Causative Agent 553 • The Immune Response 557 • Diagnosis 558 • Treatment 558 • Prevention 560 • Surveillance 560Chapter 26: Cryptosporidiosis 565Major Concepts 566 • Introduction 567 • History 568 • The Disease 569 • The Causative Agents 570 • The Immune Response 576 • Diagnosis 577 • Treatment 578 • Prevention 580 • Surveillance 581Chapter 27: Chagas’ Disease and Its Emergence in the United States 585Major Concepts 586 • Introduction 587 • History 587 • The Disease 588 • The Causative Agent 591 • The Immune Response 595 • Diagnosis 598 • Treatment 599 • Prevention 600 • Surveillance 601Part 5: Infectious ProteinsChapter 28: Creutzfeldt-Jakob Disease and Other Transmissible Spongiform Encephalopathies 609Major Concepts 610 • Introduction 611 • History 612 • The Diseases 613 • The Causative Agents 621 • The Immune Response 625 • Diagnosis 626 • Treatment 627 • Prevention 628 • Surveillance 628Part 6: Special Issues in Infectious DiseasesChapter 29: The Emerging Importance of Infectious Diseases in the Immunosuppressed 635Major Concepts 636 • Introduction 637 • Immunosuppressed Populations 637 • Selected Causes of Immunosuppression 638 • Infectious Diseases of the Immunosuppressed 642Chapter 30: The Emerging Threat of Bioweapons 667Major Concepts 668 • Introduction 669 • History 670 • Bioterrorism Agents and Diseases 671 • The Threat of Agroterrorism 692 • Preparation for Biological Attacks 693 • Protective Vaccines 694Glossary 701Index 723

Lisa A. Beltz, PhD, is assistant professor, Department of Biological Sciences, Kent State University at Tuscarawas, New Philadelphia, Ohio. Previously she was associate professor, Department of Biology, University of Northern Iowa, Cedar Falls, Iowa. Among her honors are a post-doctoral trainee fellowship at Johns Hopkins University and a SHARP Research Fellowship at the University of Pittsburgh. She won University of Northern Iowa's Biology Honors Teacher of the Year award in 2005.

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• Tables and Figures viiPreface xvThe Author xviiAcknowledgments xviiiPart 1: Introduction to Emerging Infectious DiseasesChapter 1: Infectious Diseases Past and Present 3Major Concepts 4 • History of Infectious Diseases 5 • The Role of Infectious Diseases in the World Today 8 • The Links Between Infectious Diseases, Poverty, and Civil Unrest 10 • Emerging and Reemerging Infectious Diseases 12 • Factors Contributing to the Emergence of New Infectious Diseases and the Spread and Evolution of Older Diseases 15 • Timeline 18Chapter 2: Of Microbes and Men 27Major Concepts 28 • Introduction 30 • Infectious Agents: The Enemy Combatants 30 • Genetic Information and the Making of Proteins: Preparing the Armament 36 • The Immune Response: Humans Fight Back, Part One 40 • Antimicrobial Agents: Humans Fight Back, Part Two 46Part 2: Bacterial InfectionsChapter 3: Lyme Disease 55Major Concepts 56 • Introduction 58 • History 60 • The Disease 61 • The Causative Agent 63 • The Immune Response 66 • Diagnosis 67 • Treatment 68 • Prevention 69 • Surveillance 71Chapter 4: Human Ehrlichiosis 75Major Concepts 76 • Introduction 77 • History 78 • The Diseases 79 • The Causative Agents 88 • The Immune Response 89 • Diagnosis 90 • Treatment 91 • Prevention 92 • Surveillance 92Chapter 5: Bartonella Infections 97Major Concepts 98 • Introduction 99 • History 99 • The Diseases 101 • The Causative Agents 106 • The Immune Response 109 • Diagnosis 110 • Treatment 111 • Prevention 111 • Surveillance 112Chapter 6: Group A Streptococci 117Major Concepts 118 • Introduction 119 • History 120 • The Diseases 121 • The Causative Agents 127 • The Immune Response 131 • Diagnosis 132 • Treatment 133 • Prevention 134 • Surveillance 135Chapter 7: Escherichia coli O157:H7 139Major Concepts 140 • Introduction 141 • History 142 • The Diseases 143 • The Causative Agents 145 • The Immune Response 151 • Diagnosis 152 • Treatment 153 • Prevention 153 • Surveillance 155Chapter 8: Helicobacter pylori, Ulcers, and Cancer 161Major Concepts 162 • Introduction 163 • History 164 • The Diseases 165 • The Causative Agent 168 • The Immune Response 171 • Diagnosis 172 • Treatment 173 • Prevention 174 • Surveillance 175Chapter 9: Legionnaires’ Disease and Pontiac Fever 181Major Concepts 182 • Introduction 183 • History 184 • The Diseases 185 • The Causative Agent 186 • The Immune Response 191 • Diagnosis 194 • Treatment 197 • Prevention 197 • Surveillance 199Chapter 10: Pulmonary Tuberculosis and Multidrug Resistance 205Major Concepts 206 • Introduction 207 • History 208 • The Disease 209 • The Causative Agents 212 • The Immune Response 213 • Detection and Diagnosis 214 • Treatment and Drug Resistance 216 • Prevention 219 • Surveillance 220Chapter 11: Emerging Bacterial Drug Resistance 225Major Concepts 226 • Introduction 227 • History 228 • The Diseases, Causative Agents, and Treatment Options 229 • Mechanisms of Resistance 235 • Diagnosis 239 • Prevention 240 • Surveillance 240Part 3: Viral InfectionsChapter 12: Marburg and Ebola Hemorrhagic Fevers 247Major Concepts 248 • Introduction 249 • History 250 • The Diseases 254 • The Causative Agents 257 • The Immune Response 262 • Diagnosis 263 • Treatment 264 • Prevention 264 • Surveillance 267Chapter 13: American Hemorrhagic Fevers 273Major Concepts 274 • Introduction 275 • History 277 • The Diseases 278 • The Causative Agents 282 • The Immune Response 285 • Diagnosis 286 • Treatment 287 • Prevention 287 • Surveillance 288Chapter 14: Lassa Hemorrhagic Fever 293Major Concepts 294 • Introduction 295 • History 296 • The Disease 298 • The Causative Agent 300 • The Immune Response 303 • Diagnosis 304 • Treatment 304 • Prevention 306 • Surveillance 308Chapter 15: Dengue Fever and Dengue Hemorrhagic Fever 313Major Concepts 314 • Introduction 315 • History 316 • The Diseases 318 • The Causative Agent 321 • The Immune Response 324 • Diagnosis 327 • Treatment 327 • Prevention 328 • Surveillance 329Chapter 16: The Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome 335Major Concepts 336 • Introduction 338 • History 339 • The Diseases 341 • The Causative Agent 344 • The Immune Response 350 • Diagnosis and Detection 355 • Treatment 355 • Prevention 357 • Surveillance 358Chapter 17: Human Herpesvirus 8 and Kaposi’s Sarcoma 365Major Concepts 366 • Introduction 367 • History 368 • The Diseases 368 • The Causative Agent 373 • The Immune Response 378 • Diagnosis 379 • Treatment 380 • Prevention 383 • Surveillance 383Chapter 18: Hepatitis C 389Major Concepts 390 • Introduction 391 • History 392 • The Diseases 392 • The Causative Agent 397 • The Immune Response 399 • Diagnosis 401 • Treatment 402 • Prevention 403 • Surveillance 404Chapter 19: Epidemic and Pandemic Influenza 409Major Concepts 410 • Introduction 411 • History 412 • The Disease 414 • The Causative Agent 415 • The Immune Response 421 • Diagnosis 421 • Treatment 422 • Prevention 422 • Surveillance 425Chapter 20: Hantavirus Pulmonary Syndrome 431Major Concepts 432 • Introduction 433 • History 435 • The Diseases 435 • The Causative Agents 439 • The Immune Response 444 • Diagnosis 445 • Treatment 446 • Prevention 447 • Surveillance 450Chapter 21: Severe Acute Respiratory Syndrome 455Major Concepts 456 • Introduction 457 • History 457 • The Disease 460 • The Causative Agent 461 • The Immune Response 464 • Diagnosis 465 • Treatment 466 • Prevention 467 • Surveillance 469Chapter 22: West Nile Disease in the United States 475Major Concepts 476 • Introduction 477 • History 477 • The Diseases 481 • The Causative Agent 484 • The Immune Response 487 • Diagnosis 488 • Treatment 489 • Prevention 490 • Surveillance 493Chapter 23: Monkeypox 499Major Concepts 500 • Introduction 501 • History 502 • The Disease 505 • The Causative Agent 508 • The Immune Response 511 • Diagnosis 513 • Treatment 514 • Prevention 514 • Surveillance 516Part 4: Parasitic InfectionsChapter 24: Malaria: Reemergence and Recent Successes 523Major Concepts 524 • Introduction 526 • History 526 • The Disease 528 • The Causative Agents 529 • The Immune Response 533 • Diagnosis 535 • Treatment and Drug Resistance 535 • Prevention: Failures and Successes 537 • Surveillance 541Chapter 25: Babesiosis 547Major Concepts 548 • Introduction 549 • History 549 • The Disease 550• The Causative Agent 553 • The Immune Response 557 • Diagnosis 558 • Treatment 558 • Prevention 560 • Surveillance 560Chapter 26: Cryptosporidiosis 565Major Concepts 566 • Introduction 567 • History 568 • The Disease 569 • The Causative Agents 570 • The Immune Response 576 • Diagnosis 577 • Treatment 578 • Prevention 580 • Surveillance 581Chapter 27: Chagas’ Disease and Its Emergence in the United States 585Major Concepts 586 • Introduction 587 • History 587 • The Disease 588 • The Causative Agent 591 • The Immune Response 595 • Diagnosis 598 • Treatment 599 • Prevention 600 • Surveillance 601Part 5: Infectious ProteinsChapter 28: Creutzfeldt-Jakob Disease and Other Transmissible Spongiform Encephalopathies 609Major Concepts 610 • Introduction 611 • History 612 • The Diseases 613 • The Causative Agents 621 • The Immune Response 625 • Diagnosis 626 • Treatment 627 • Prevention 628 • Surveillance 628Part 6: Special Issues in Infectious DiseasesChapter 29: The Emerging Importance of Infectious Diseases in the Immunosuppressed 635Major Concepts 636 • Introduction 637 • Immunosuppressed Populations 637 • Selected Causes of Immunosuppression 638 • Infectious Diseases of the Immunosuppressed 642Chapter 30: The Emerging Threat of Bioweapons 667Major Concepts 668 • Introduction 669 • History 670 • Bioterrorism Agents and Diseases 671 • The Threat of Agroterrorism 692 • Preparation for Biological Attacks 693 • Protective Vaccines 694Glossary 701Index 723

Lisa A. Beltz, PhD, is assistant professor, Department of Biological Sciences, Kent State University at Tuscarawas, New Philadelphia, Ohio. Previously she was associate professor, Department of Biology, University of Northern Iowa, Cedar Falls, Iowa. Among her honors are a post-doctoral trainee fellowship at Johns Hopkins University and a SHARP Research Fellowship at the University of Pittsburgh. She won University of Northern Iowa's Biology Honors Teacher of the Year award in 2005.

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• Tables and Figures viiPreface xvThe Author xviiAcknowledgments xviiiPart 1: Introduction to Emerging Infectious DiseasesChapter 1: Infectious Diseases Past and Present 3Major Concepts 4 • History of Infectious Diseases 5 • The Role of Infectious Diseases in the World Today 8 • The Links Between Infectious Diseases, Poverty, and Civil Unrest 10 • Emerging and Reemerging Infectious Diseases 12 • Factors Contributing to the Emergence of New Infectious Diseases and the Spread and Evolution of Older Diseases 15 • Timeline 18Chapter 2: Of Microbes and Men 27Major Concepts 28 • Introduction 30 • Infectious Agents: The Enemy Combatants 30 • Genetic Information and the Making of Proteins: Preparing the Armament 36 • The Immune Response: Humans Fight Back, Part One 40 • Antimicrobial Agents: Humans Fight Back, Part Two 46Part 2: Bacterial InfectionsChapter 3: Lyme Disease 55Major Concepts 56 • Introduction 58 • History 60 • The Disease 61 • The Causative Agent 63 • The Immune Response 66 • Diagnosis 67 • Treatment 68 • Prevention 69 • Surveillance 71Chapter 4: Human Ehrlichiosis 75Major Concepts 76 • Introduction 77 • History 78 • The Diseases 79 • The Causative Agents 88 • The Immune Response 89 • Diagnosis 90 • Treatment 91 • Prevention 92 • Surveillance 92Chapter 5: Bartonella Infections 97Major Concepts 98 • Introduction 99 • History 99 • The Diseases 101 • The Causative Agents 106 • The Immune Response 109 • Diagnosis 110 • Treatment 111 • Prevention 111 • Surveillance 112Chapter 6: Group A Streptococci 117Major Concepts 118 • Introduction 119 • History 120 • The Diseases 121 • The Causative Agents 127 • The Immune Response 131 • Diagnosis 132 • Treatment 133 • Prevention 134 • Surveillance 135Chapter 7: Escherichia coli O157:H7 139Major Concepts 140 • Introduction 141 • History 142 • The Diseases 143 • The Causative Agents 145 • The Immune Response 151 • Diagnosis 152 • Treatment 153 • Prevention 153 • Surveillance 155Chapter 8: Helicobacter pylori, Ulcers, and Cancer 161Major Concepts 162 • Introduction 163 • History 164 • The Diseases 165 • The Causative Agent 168 • The Immune Response 171 • Diagnosis 172 • Treatment 173 • Prevention 174 • Surveillance 175Chapter 9: Legionnaires’ Disease and Pontiac Fever 181Major Concepts 182 • Introduction 183 • History 184 • The Diseases 185 • The Causative Agent 186 • The Immune Response 191 • Diagnosis 194 • Treatment 197 • Prevention 197 • Surveillance 199Chapter 10: Pulmonary Tuberculosis and Multidrug Resistance 205Major Concepts 206 • Introduction 207 • History 208 • The Disease 209 • The Causative Agents 212 • The Immune Response 213 • Detection and Diagnosis 214 • Treatment and Drug Resistance 216 • Prevention 219 • Surveillance 220Chapter 11: Emerging Bacterial Drug Resistance 225Major Concepts 226 • Introduction 227 • History 228 • The Diseases, Causative Agents, and Treatment Options 229 • Mechanisms of Resistance 235 • Diagnosis 239 • Prevention 240 • Surveillance 240Part 3: Viral InfectionsChapter 12: Marburg and Ebola Hemorrhagic Fevers 247Major Concepts 248 • Introduction 249 • History 250 • The Diseases 254 • The Causative Agents 257 • The Immune Response 262 • Diagnosis 263 • Treatment 264 • Prevention 264 • Surveillance 267Chapter 13: American Hemorrhagic Fevers 273Major Concepts 274 • Introduction 275 • History 277 • The Diseases 278 • The Causative Agents 282 • The Immune Response 285 • Diagnosis 286 • Treatment 287 • Prevention 287 • Surveillance 288Chapter 14: Lassa Hemorrhagic Fever 293Major Concepts 294 • Introduction 295 • History 296 • The Disease 298 • The Causative Agent 300 • The Immune Response 303 • Diagnosis 304 • Treatment 304 • Prevention 306 • Surveillance 308Chapter 15: Dengue Fever and Dengue Hemorrhagic Fever 313Major Concepts 314 • Introduction 315 • History 316 • The Diseases 318 • The Causative Agent 321 • The Immune Response 324 • Diagnosis 327 • Treatment 327 • Prevention 328 • Surveillance 329Chapter 16: The Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome 335Major Concepts 336 • Introduction 338 • History 339 • The Diseases 341 • The Causative Agent 344 • The Immune Response 350 • Diagnosis and Detection 355 • Treatment 355 • Prevention 357 • Surveillance 358Chapter 17: Human Herpesvirus 8 and Kaposi’s Sarcoma 365Major Concepts 366 • Introduction 367 • History 368 • The Diseases 368 • The Causative Agent 373 • The Immune Response 378 • Diagnosis 379 • Treatment 380 • Prevention 383 • Surveillance 383Chapter 18: Hepatitis C 389Major Concepts 390 • Introduction 391 • History 392 • The Diseases 392 • The Causative Agent 397 • The Immune Response 399 • Diagnosis 401 • Treatment 402 • Prevention 403 • Surveillance 404Chapter 19: Epidemic and Pandemic Influenza 409Major Concepts 410 • Introduction 411 • History 412 • The Disease 414 • The Causative Agent 415 • The Immune Response 421 • Diagnosis 421 • Treatment 422 • Prevention 422 • Surveillance 425Chapter 20: Hantavirus Pulmonary Syndrome 431Major Concepts 432 • Introduction 433 • History 435 • The Diseases 435 • The Causative Agents 439 • The Immune Response 444 • Diagnosis 445 • Treatment 446 • Prevention 447 • Surveillance 450Chapter 21: Severe Acute Respiratory Syndrome 455Major Concepts 456 • Introduction 457 • History 457 • The Disease 460 • The Causative Agent 461 • The Immune Response 464 • Diagnosis 465 • Treatment 466 • Prevention 467 • Surveillance 469Chapter 22: West Nile Disease in the United States 475Major Concepts 476 • Introduction 477 • History 477 • The Diseases 481 • The Causative Agent 484 • The Immune Response 487 • Diagnosis 488 • Treatment 489 • Prevention 490 • Surveillance 493Chapter 23: Monkeypox 499Major Concepts 500 • Introduction 501 • History 502 • The Disease 505 • The Causative Agent 508 • The Immune Response 511 • Diagnosis 513 • Treatment 514 • Prevention 514 • Surveillance 516Part 4: Parasitic InfectionsChapter 24: Malaria: Reemergence and Recent Successes 523Major Concepts 524 • Introduction 526 • History 526 • The Disease 528 • The Causative Agents 529 • The Immune Response 533 • Diagnosis 535 • Treatment and Drug Resistance 535 • Prevention: Failures and Successes 537 • Surveillance 541Chapter 25: Babesiosis 547Major Concepts 548 • Introduction 549 • History 549 • The Disease 550• The Causative Agent 553 • The Immune Response 557 • Diagnosis 558 • Treatment 558 • Prevention 560 • Surveillance 560Chapter 26: Cryptosporidiosis 565Major Concepts 566 • Introduction 567 • History 568 • The Disease 569 • The Causative Agents 570 • The Immune Response 576 • Diagnosis 577 • Treatment 578 • Prevention 580 • Surveillance 581Chapter 27: Chagas’ Disease and Its Emergence in the United States 585Major Concepts 586 • Introduction 587 • History 587 • The Disease 588 • The Causative Agent 591 • The Immune Response 595 • Diagnosis 598 • Treatment 599 • Prevention 600 • Surveillance 601Part 5: Infectious ProteinsChapter 28: Creutzfeldt-Jakob Disease and Other Transmissible Spongiform Encephalopathies 609Major Concepts 610 • Introduction 611 • History 612 • The Diseases 613 • The Causative Agents 621 • The Immune Response 625 • Diagnosis 626 • Treatment 627 • Prevention 628 • Surveillance 628Part 6: Special Issues in Infectious DiseasesChapter 29: The Emerging Importance of Infectious Diseases in the Immunosuppressed 635Major Concepts 636 • Introduction 637 • Immunosuppressed Populations 637 • Selected Causes of Immunosuppression 638 • Infectious Diseases of the Immunosuppressed 642Chapter 30: The Emerging Threat of Bioweapons 667Major Concepts 668 • Introduction 669 • History 670 • Bioterrorism Agents and Diseases 671 • The Threat of Agroterrorism 692 • Preparation for Biological Attacks 693 • Protective Vaccines 694Glossary 701Index 723