LOUIS J. DiBERARDINIS, BS, MS, CIH, CSP, is the Director of Environment, Health, and Safety at MIT. He is a visiting lecturer at Harvard University School of Public Health and Adjunct Professor at the University of Massachusetts Lowell in the Department of the Work Environment. He received his BS in chemical engineering from Northeastern University and an MS in industrial hygiene from Harvard University.JANET S. BAUM, BS, MArch, AiA, currently teaches part-time at Harvard University School of Public Health and at both the Graduate School of Architecture and Urban Design and the Institute of Public Health, Washington University in St. Louis. She earned her BS in architectural sciences at Washington University in St. Louis and her master of architecture at Harvard University Graduate School of Design.The late MELVIN W. FIRST, ScD, CIH, PE, was a researcher and professor of environmental health Engineering at the Harvard School of Public Health for almost sixty years and was actively involved in research until a week before his death.GARI T. GATWOOD, BSME, CSP (retired), is a consultant in safety engineering. He has forty years of safety experience in missile defense, commercial chemicals, laboratories, and university programs. He holds a degree in mechanical engineering from the Missouri School of Mines and Metallurgy in Rolla, Missouri.Anand K. Seth, BS, MS, PE, CEM, CPE, is currently an Engineering Principal in Cannon Design, an international architectural/engineering firm. Seth worked at Massachusetts General Hospital as director of engineering and at Harvard University. He holds a master of science in mechanical engineering from the University of Maine and has done postgraduate work at other universities.

“In summary, this edition of the book addresses a broad spectrum of end users including administrators, researchers, instructors, engineers, and environment health officers. The book is a useful comprehensive reference for academic institutions, but perhaps not for individual instructors.”  (Journal of Chemical Education, 1 January 2014)

• Foreword xvPreface xviiAcknowledgments xixAbout the Authors xxiAbbreviations xxiiiUnits xxvOrganizations Referenced xxviiIntroduction xxixHow to Use This Book xxxBook Organization xxxiComputational Fluid Dynamics xxxiiiPart IA Common Elements of Laboratory Design 11 Building Considerations 31.1 Guiding Concepts 31.2 Building Layout 31.3 Guiding Principles for Building Heating Ventilating and Air-Conditioning Systems 441.4 Guiding Concepts for Laboratory Building Loss Prevention Industrial Hygiene and Personal Safety 511.5 Miscellaneous Services 562 Laboratory Considerations 65Part IB Common Elements of Renovations 1093 Renovations: Building Considerations 1233.1 Guiding Concepts 1233.2 Building Layout 1253.3 Heating Ventilating and Air-Conditioning Systems 1293.4 Loss Prevention Industrial Hygiene and Personal Safety 1333.5 Miscellaneous Services 1344 Renovations: Laboratory Considerations 1364.1 Guiding Concepts 1364.2 Laboratory Layout 1374.3 Heating Ventilating and Air-Conditioning Systems 1384.4 Loss Prevention Industrial Hygiene and Personal Safety 138Part II Design Guidelines for a Number of Commonly Used Laboratories 1415 General or Analytical Chemistry Laboratory 1435.1 Description 1435.2 Laboratory Layout 1445.3 Heating Ventilating and Air-Conditioning 1465.4 Loss Prevention Industrial Hygiene and Personal Safety 1495.5 Special Requirements 1496 High-Toxicity Laboratory 1506.1 Description 1506.2 Laboratory Layout 1516.3 Heating Ventilating and Air-Conditioning 1536.4 Loss Prevention Industrial Hygiene and Personal Safety 1546.5 Special Requirements 1557 Nanotechnology Laboratories 1567.1 Description 1567.2 Laboratory Layout 1567.3 Heating Ventilating and Air-Conditioning 1577.4 Loss Prevention Industrial Hygiene and Personal Safety 1588 Engineering Laboratories 1608.1 Description 1608.2 Engineering Disciplines and Some of Their Most Common Laboratory Types 1608.3 Wind Tunnel Laboratory 1618.4 Jet and Rocket Propulsion Laboratory 1628.5 Hydraulics Laboratory 1648.6 Material Analysis and Testing Laboratory 1658.7 Electrical Circuits Motors and Generators Laboratory 1658.8 Foundry Laboratory 1678.9 Internal Combustion and Gas Turbine Engine Laboratory 1699 Pilot Plant: Chemical Engineering and Biological 1739.1 Description 1739.2 Pilot Plant Layout 1749.3 Heating Ventilating and Air-Conditioning 1749.4 Loss Prevention Industrial Hygiene and Personal Safety 1759.5 Special Requirements 17510 Physics Laboratory 17710.1 Description 17710.2 Laboratory Layout 17810.3 Heating Ventilating and Air-Conditioning 17910.4 Loss Prevention Industrial Hygiene and Personal Safety 17910.5 Special Requirements 18111 Controlled Environment Room: Hot or Cold 18211.1 Description 18211.2 Laboratory Layout 18311.3 Heating Ventilating and Air-Conditioning 18311.4 Loss Prevention 18511.5 Special Requirements 18512 High-Pressure Laboratory 18712.1 Description 18712.2 Laboratory Layout 18812.3 Heating Ventilating and Air-Conditioning 18812.4 Loss Prevention Industrial Hygiene and Personal Safety 18912.5 Special Requirements 18913 Radiation Laboratory 19013.1 Description 19013.2 Laboratory Layout 19113.3 Heating Ventilating and Air-Conditioning 19413.4 Loss Prevention Industrial Hygiene and Personal Safety 19513.5 Special Considerations 19514 Biosafety Laboratory 19614.1 Description 19614.2 Laboratory Layout 20214.3 Heating Ventilating and Air-Conditioning 21214.4 Loss Prevention Industrial Hygiene and Personal Safety 21314.5 Special Requirements 21315 Clinical Laboratories 21615.1 Description 21615.2 Laboratory Layout 21815.3 Heating Ventilating and Air-Conditioning 22215.4 Loss Prevention Industrial Hygiene and Personal Safety 22316 Teaching Laboratory 22716.1 Description 22716.2 Laboratory Layout 22816.3 Heating Ventilating and Air-Conditioning 23416.4 Loss Prevention Industrial Hygiene and Personal Safety 23517 Gross Anatomy Laboratory 23817.1 Description 23817.2 Laboratory Layout 23917.3 Heating Ventilating and Air-Conditioning 24317.4 Loss Prevention Industrial Hygiene and Personal Safety 24417.5 Security 24518 Pathology Laboratory 24618.1 Description 24618.2 Laboratory Layout 24918.3 Heating Ventilating and Air-Conditioning 25118.4 Loss Prevention Industrial Hygiene and Personal Safety 25118.5 Special Requirements 25219 Autopsy Laboratory 25319.1 Description 25319.2 Laboratory Layout 25519.3 Heating Ventilating and Air-Conditioning 26019.4 Loss Prevention Industrial Hygiene and Personal Safety 26120 Morgue Facility 26220.1 Description 26220.2 Laboratory Layout 26520.3 Heating Ventilating and Air-Conditioning 26920.4 Loss Prevention Industrial Hygiene and Personal Safety 26921 Open or Team Research Laboratory 27121.1 Description 27121.2 Laboratory Layout 27221.3 Heating Ventilating and Air-Conditioning 27521.4 Loss Prevention Industrial Hygiene and Personal Safety 27521.5 Special Considerations 27622 Animal Research Laboratory 27722.1 Description 27722.2 Laboratory Layout 27922.3 Heating Ventilating and Air-Conditioning 29222.4 Loss Prevention Industrial Hygiene and Personal Safety 29622.5 Special Requirements 29723 Microelectronics and Cleanroom Laboratories 29923.1 Description 29923.2 Laboratory Layout 30323.3 Heating Ventilating and Air Conditioning 30723.4 Loss Prevention Industrial Hygiene and Personnel Safety 31023.5 Special Requirements 31223.6 Renovations 31424 Printmaking Studio 31524.1 Description 31524.2 Print Studio Layout 31724.3 Heating Ventilating and Air-Conditioning 31824.4 Loss Prevention Industrial Hygiene and Personal Safety 321Part III Laboratory Support Services 32525 Imaging and Photographic Facilities 32725.1 Introduction 32725.2 Photographic And Imaging Facility Layouts 33125.3 Heating Ventilating and Air-Conditioning 33425.4 Loss Prevention Industrial Hygiene and Personal Safety 33625.5 Special Requirements 33726 Support Shops 33926.1 Description 33926.2 Layout 34026.3 Heating Ventilating and Air-Conditioning 34426.4 Loss Prevention Industrial Hygiene and Personal Safety 34626.5 Special Requirements 34627 Hazardous Chemical Radioactive and Biological Waste-Handling Rooms 34827.1 Guiding Concepts 34827.2 Layout 35127.3 Heating Ventilating and Air-Conditioning 35627.4 Loss Prevention Industrial Hygiene and Personal Safety 35827.5 Special Requirements 35828 Laboratory Storerooms 36028.1 Description 36028.2 Layout 36328.3 Heating Ventilating and Air-Conditioning 36628.4 Loss Prevention Industrial Hygiene and Personal Safety 36728.5 Special Requirements 368Part IV Hvac Systems 36929 HVAC Systems 37129.1 Description 37129.2 Air-Conditioning Systems 37129.3 HVAC System Design and Description 37629.4 System Descriptions and Strategies 37729.5 Humidification and Dehumidification 38629.6 Space Pressure Control 38929.7 Automatic Control System 39130 Fans 39230.1 Fan Terminology 39230.2 Exhaust Fan Specifications 39330.3 Atmospheric Dispersion 39430.4 Fan Laws 39430.5 Fan Selection 39530.6 Fan Performance 39631 Air Cleaning 39731.1 Introduction 39731.2 Air-Cleaning Equipment for Laboratories 39832 Laboratory Hoods and Other Exhaust Air Contaminant-Capture Facilities and Equipment 40432.1 Introduction 40432.2 Conventional Bypass Chemical Fume Hoods 40532.3 Auxiliary Air Chemical Fume Hoods 40932.4 Perchloric Acid Fume Hoods 41132.5 Hoods for Work With Radioactive Materials 41132.6 Variable Air-Volume Hoods 41132.7 High-Performance Hoods 41232.8 Gloveboxes 41232.9 Biological Safety Cabinets 41332.10 Capture (Exterior) Hoods 41632.11 Ductless Hoods 41632.12 Performance Tests 42033 Exhaust Air Ducts and Accessories 42233.1 Introduction 42233.2 Exhaust Duct Considerations 42333.3 Exhaust System Classification 42433.4 Duct Accessories 42434 Variable-Air-Volume Systems 42634.1 Introduction 42634.2 VAV Hoods 42734.3 Good Design Practices for Vav Systems 42834.4 Variable-Volume Exhaust System Operational Concept 42834.5 VAV System Controls and Components 42934.6 VAV System Fan Controls and Components 43134.7 VAV System Duct Configurations 43435 Energy Conservation 43635.1 Introduction 43635.2 Recent Trends 43735.3 Exhaust Ventilation for Contamination Control 44035.4 Lighting 44835.5 Thermal Insulation 44835.6 Humidity Control 44835.7 Evaporative Cooling 44935.8 Water Conservation 44935.9 Efficient Operating Strategies 449Part V Administrative Procedures 45136 Project Execution and Bidding Procedures 45336.1 Guiding Concepts 45336.2 Implementation 45436.3 Bid Form 45636.4 Contract 45736.5 Change Orders 45736.6 Construction Inspections 45836.7 Punch List 45836.8 Additional Testing and Acceptance 45836.9 Beneficial Occupancy 45936.10 Final Acceptance and Commissioning 45937 Commissioning and Final Acceptance Criteria 46037.1 Guiding Concepts 46037.2 Design Construction and Preoccupancy Checklists 46037.3 Heating Ventilating and Air-Conditioning 46237.4 Loss Prevention Industrial Hygiene and Personal Safety 46637.5 Project Commissioning 46738 Sustainable Laboratory Design 47138.1 Introduction 47138.2 Laboratory Construction Materials 47238.3 Heating Ventilating and Air-Conditioning 47438.4 Loss Prevention Industrial Hygiene and Personal Safety 47738.5 Miscellaneous Services 47738.6 Lighting 47838.7 Submetering 47938.8 Additional Background Material 479Part VI Appendixes 481Appendix A Emergency Showers 483Appendix B Emergency Eyewash Units 485Appendix c Signs 486Appendix D Stack Design 489Appendix E Matrix of Building Consideration for Specific Laboratory Types 495References 500Index 509

LOUIS J. DiBERARDINIS, BS, MS, CIH, CSP, is the Director of Environment, Health, and Safety at MIT. He is a visiting lecturer at Harvard University School of Public Health and Adjunct Professor at the University of Massachusetts Lowell in the Department of the Work Environment. He received his BS in chemical engineering from Northeastern University and an MS in industrial hygiene from Harvard University.JANET S. BAUM, BS, MArch, AiA, currently teaches part-time at Harvard University School of Public Health and at both the Graduate School of Architecture and Urban Design and the Institute of Public Health, Washington University in St. Louis. She earned her BS in architectural sciences at Washington University in St. Louis and her master of architecture at Harvard University Graduate School of Design.The late MELVIN W. FIRST, ScD, CIH, PE, was a researcher and professor of environmental health Engineering at the Harvard School of Public Health for almost sixty years and was actively involved in research until a week before his death.GARI T. GATWOOD, BSME, CSP (retired), is a consultant in safety engineering. He has forty years of safety experience in missile defense, commercial chemicals, laboratories, and university programs. He holds a degree in mechanical engineering from the Missouri School of Mines and Metallurgy in Rolla, Missouri.Anand K. Seth, BS, MS, PE, CEM, CPE, is currently an Engineering Principal in Cannon Design, an international architectural/engineering firm. Seth worked at Massachusetts General Hospital as director of engineering and at Harvard University. He holds a master of science in mechanical engineering from the University of Maine and has done postgraduate work at other universities.

“In summary, this edition of the book addresses a broad spectrum of end users including administrators, researchers, instructors, engineers, and environment health officers. The book is a useful comprehensive reference for academic institutions, but perhaps not for individual instructors.”  (Journal of Chemical Education, 1 January 2014)

• Foreword xvPreface xviiAcknowledgments xixAbout the Authors xxiAbbreviations xxiiiUnits xxvOrganizations Referenced xxviiIntroduction xxixHow to Use This Book xxxBook Organization xxxiComputational Fluid Dynamics xxxiiiPart IA Common Elements of Laboratory Design 11 Building Considerations 31.1 Guiding Concepts 31.2 Building Layout 31.3 Guiding Principles for Building Heating Ventilating and Air-Conditioning Systems 441.4 Guiding Concepts for Laboratory Building Loss Prevention Industrial Hygiene and Personal Safety 511.5 Miscellaneous Services 562 Laboratory Considerations 65Part IB Common Elements of Renovations 1093 Renovations: Building Considerations 1233.1 Guiding Concepts 1233.2 Building Layout 1253.3 Heating Ventilating and Air-Conditioning Systems 1293.4 Loss Prevention Industrial Hygiene and Personal Safety 1333.5 Miscellaneous Services 1344 Renovations: Laboratory Considerations 1364.1 Guiding Concepts 1364.2 Laboratory Layout 1374.3 Heating Ventilating and Air-Conditioning Systems 1384.4 Loss Prevention Industrial Hygiene and Personal Safety 138Part II Design Guidelines for a Number of Commonly Used Laboratories 1415 General or Analytical Chemistry Laboratory 1435.1 Description 1435.2 Laboratory Layout 1445.3 Heating Ventilating and Air-Conditioning 1465.4 Loss Prevention Industrial Hygiene and Personal Safety 1495.5 Special Requirements 1496 High-Toxicity Laboratory 1506.1 Description 1506.2 Laboratory Layout 1516.3 Heating Ventilating and Air-Conditioning 1536.4 Loss Prevention Industrial Hygiene and Personal Safety 1546.5 Special Requirements 1557 Nanotechnology Laboratories 1567.1 Description 1567.2 Laboratory Layout 1567.3 Heating Ventilating and Air-Conditioning 1577.4 Loss Prevention Industrial Hygiene and Personal Safety 1588 Engineering Laboratories 1608.1 Description 1608.2 Engineering Disciplines and Some of Their Most Common Laboratory Types 1608.3 Wind Tunnel Laboratory 1618.4 Jet and Rocket Propulsion Laboratory 1628.5 Hydraulics Laboratory 1648.6 Material Analysis and Testing Laboratory 1658.7 Electrical Circuits Motors and Generators Laboratory 1658.8 Foundry Laboratory 1678.9 Internal Combustion and Gas Turbine Engine Laboratory 1699 Pilot Plant: Chemical Engineering and Biological 1739.1 Description 1739.2 Pilot Plant Layout 1749.3 Heating Ventilating and Air-Conditioning 1749.4 Loss Prevention Industrial Hygiene and Personal Safety 1759.5 Special Requirements 17510 Physics Laboratory 17710.1 Description 17710.2 Laboratory Layout 17810.3 Heating Ventilating and Air-Conditioning 17910.4 Loss Prevention Industrial Hygiene and Personal Safety 17910.5 Special Requirements 18111 Controlled Environment Room: Hot or Cold 18211.1 Description 18211.2 Laboratory Layout 18311.3 Heating Ventilating and Air-Conditioning 18311.4 Loss Prevention 18511.5 Special Requirements 18512 High-Pressure Laboratory 18712.1 Description 18712.2 Laboratory Layout 18812.3 Heating Ventilating and Air-Conditioning 18812.4 Loss Prevention Industrial Hygiene and Personal Safety 18912.5 Special Requirements 18913 Radiation Laboratory 19013.1 Description 19013.2 Laboratory Layout 19113.3 Heating Ventilating and Air-Conditioning 19413.4 Loss Prevention Industrial Hygiene and Personal Safety 19513.5 Special Considerations 19514 Biosafety Laboratory 19614.1 Description 19614.2 Laboratory Layout 20214.3 Heating Ventilating and Air-Conditioning 21214.4 Loss Prevention Industrial Hygiene and Personal Safety 21314.5 Special Requirements 21315 Clinical Laboratories 21615.1 Description 21615.2 Laboratory Layout 21815.3 Heating Ventilating and Air-Conditioning 22215.4 Loss Prevention Industrial Hygiene and Personal Safety 22316 Teaching Laboratory 22716.1 Description 22716.2 Laboratory Layout 22816.3 Heating Ventilating and Air-Conditioning 23416.4 Loss Prevention Industrial Hygiene and Personal Safety 23517 Gross Anatomy Laboratory 23817.1 Description 23817.2 Laboratory Layout 23917.3 Heating Ventilating and Air-Conditioning 24317.4 Loss Prevention Industrial Hygiene and Personal Safety 24417.5 Security 24518 Pathology Laboratory 24618.1 Description 24618.2 Laboratory Layout 24918.3 Heating Ventilating and Air-Conditioning 25118.4 Loss Prevention Industrial Hygiene and Personal Safety 25118.5 Special Requirements 25219 Autopsy Laboratory 25319.1 Description 25319.2 Laboratory Layout 25519.3 Heating Ventilating and Air-Conditioning 26019.4 Loss Prevention Industrial Hygiene and Personal Safety 26120 Morgue Facility 26220.1 Description 26220.2 Laboratory Layout 26520.3 Heating Ventilating and Air-Conditioning 26920.4 Loss Prevention Industrial Hygiene and Personal Safety 26921 Open or Team Research Laboratory 27121.1 Description 27121.2 Laboratory Layout 27221.3 Heating Ventilating and Air-Conditioning 27521.4 Loss Prevention Industrial Hygiene and Personal Safety 27521.5 Special Considerations 27622 Animal Research Laboratory 27722.1 Description 27722.2 Laboratory Layout 27922.3 Heating Ventilating and Air-Conditioning 29222.4 Loss Prevention Industrial Hygiene and Personal Safety 29622.5 Special Requirements 29723 Microelectronics and Cleanroom Laboratories 29923.1 Description 29923.2 Laboratory Layout 30323.3 Heating Ventilating and Air Conditioning 30723.4 Loss Prevention Industrial Hygiene and Personnel Safety 31023.5 Special Requirements 31223.6 Renovations 31424 Printmaking Studio 31524.1 Description 31524.2 Print Studio Layout 31724.3 Heating Ventilating and Air-Conditioning 31824.4 Loss Prevention Industrial Hygiene and Personal Safety 321Part III Laboratory Support Services 32525 Imaging and Photographic Facilities 32725.1 Introduction 32725.2 Photographic And Imaging Facility Layouts 33125.3 Heating Ventilating and Air-Conditioning 33425.4 Loss Prevention Industrial Hygiene and Personal Safety 33625.5 Special Requirements 33726 Support Shops 33926.1 Description 33926.2 Layout 34026.3 Heating Ventilating and Air-Conditioning 34426.4 Loss Prevention Industrial Hygiene and Personal Safety 34626.5 Special Requirements 34627 Hazardous Chemical Radioactive and Biological Waste-Handling Rooms 34827.1 Guiding Concepts 34827.2 Layout 35127.3 Heating Ventilating and Air-Conditioning 35627.4 Loss Prevention Industrial Hygiene and Personal Safety 35827.5 Special Requirements 35828 Laboratory Storerooms 36028.1 Description 36028.2 Layout 36328.3 Heating Ventilating and Air-Conditioning 36628.4 Loss Prevention Industrial Hygiene and Personal Safety 36728.5 Special Requirements 368Part IV Hvac Systems 36929 HVAC Systems 37129.1 Description 37129.2 Air-Conditioning Systems 37129.3 HVAC System Design and Description 37629.4 System Descriptions and Strategies 37729.5 Humidification and Dehumidification 38629.6 Space Pressure Control 38929.7 Automatic Control System 39130 Fans 39230.1 Fan Terminology 39230.2 Exhaust Fan Specifications 39330.3 Atmospheric Dispersion 39430.4 Fan Laws 39430.5 Fan Selection 39530.6 Fan Performance 39631 Air Cleaning 39731.1 Introduction 39731.2 Air-Cleaning Equipment for Laboratories 39832 Laboratory Hoods and Other Exhaust Air Contaminant-Capture Facilities and Equipment 40432.1 Introduction 40432.2 Conventional Bypass Chemical Fume Hoods 40532.3 Auxiliary Air Chemical Fume Hoods 40932.4 Perchloric Acid Fume Hoods 41132.5 Hoods for Work With Radioactive Materials 41132.6 Variable Air-Volume Hoods 41132.7 High-Performance Hoods 41232.8 Gloveboxes 41232.9 Biological Safety Cabinets 41332.10 Capture (Exterior) Hoods 41632.11 Ductless Hoods 41632.12 Performance Tests 42033 Exhaust Air Ducts and Accessories 42233.1 Introduction 42233.2 Exhaust Duct Considerations 42333.3 Exhaust System Classification 42433.4 Duct Accessories 42434 Variable-Air-Volume Systems 42634.1 Introduction 42634.2 VAV Hoods 42734.3 Good Design Practices for Vav Systems 42834.4 Variable-Volume Exhaust System Operational Concept 42834.5 VAV System Controls and Components 42934.6 VAV System Fan Controls and Components 43134.7 VAV System Duct Configurations 43435 Energy Conservation 43635.1 Introduction 43635.2 Recent Trends 43735.3 Exhaust Ventilation for Contamination Control 44035.4 Lighting 44835.5 Thermal Insulation 44835.6 Humidity Control 44835.7 Evaporative Cooling 44935.8 Water Conservation 44935.9 Efficient Operating Strategies 449Part V Administrative Procedures 45136 Project Execution and Bidding Procedures 45336.1 Guiding Concepts 45336.2 Implementation 45436.3 Bid Form 45636.4 Contract 45736.5 Change Orders 45736.6 Construction Inspections 45836.7 Punch List 45836.8 Additional Testing and Acceptance 45836.9 Beneficial Occupancy 45936.10 Final Acceptance and Commissioning 45937 Commissioning and Final Acceptance Criteria 46037.1 Guiding Concepts 46037.2 Design Construction and Preoccupancy Checklists 46037.3 Heating Ventilating and Air-Conditioning 46237.4 Loss Prevention Industrial Hygiene and Personal Safety 46637.5 Project Commissioning 46738 Sustainable Laboratory Design 47138.1 Introduction 47138.2 Laboratory Construction Materials 47238.3 Heating Ventilating and Air-Conditioning 47438.4 Loss Prevention Industrial Hygiene and Personal Safety 47738.5 Miscellaneous Services 47738.6 Lighting 47838.7 Submetering 47938.8 Additional Background Material 479Part VI Appendixes 481Appendix A Emergency Showers 483Appendix B Emergency Eyewash Units 485Appendix c Signs 486Appendix D Stack Design 489Appendix E Matrix of Building Consideration for Specific Laboratory Types 495References 500Index 509

LOUIS J. DiBERARDINIS, BS, MS, CIH, CSP, is the Director of Environment, Health, and Safety at MIT. He is a visiting lecturer at Harvard University School of Public Health and Adjunct Professor at the University of Massachusetts Lowell in the Department of the Work Environment. He received his BS in chemical engineering from Northeastern University and an MS in industrial hygiene from Harvard University.JANET S. BAUM, BS, MArch, AiA, currently teaches part-time at Harvard University School of Public Health and at both the Graduate School of Architecture and Urban Design and the Institute of Public Health, Washington University in St. Louis. She earned her BS in architectural sciences at Washington University in St. Louis and her master of architecture at Harvard University Graduate School of Design.The late MELVIN W. FIRST, ScD, CIH, PE, was a researcher and professor of environmental health Engineering at the Harvard School of Public Health for almost sixty years and was actively involved in research until a week before his death.GARI T. GATWOOD, BSME, CSP (retired), is a consultant in safety engineering. He has forty years of safety experience in missile defense, commercial chemicals, laboratories, and university programs. He holds a degree in mechanical engineering from the Missouri School of Mines and Metallurgy in Rolla, Missouri.Anand K. Seth, BS, MS, PE, CEM, CPE, is currently an Engineering Principal in Cannon Design, an international architectural/engineering firm. Seth worked at Massachusetts General Hospital as director of engineering and at Harvard University. He holds a master of science in mechanical engineering from the University of Maine and has done postgraduate work at other universities.

“In summary, this edition of the book addresses a broad spectrum of end users including administrators, researchers, instructors, engineers, and environment health officers. The book is a useful comprehensive reference for academic institutions, but perhaps not for individual instructors.”  (Journal of Chemical Education, 1 January 2014)

• Foreword xvPreface xviiAcknowledgments xixAbout the Authors xxiAbbreviations xxiiiUnits xxvOrganizations Referenced xxviiIntroduction xxixHow to Use This Book xxxBook Organization xxxiComputational Fluid Dynamics xxxiiiPart IA Common Elements of Laboratory Design 11 Building Considerations 31.1 Guiding Concepts 31.2 Building Layout 31.3 Guiding Principles for Building Heating Ventilating and Air-Conditioning Systems 441.4 Guiding Concepts for Laboratory Building Loss Prevention Industrial Hygiene and Personal Safety 511.5 Miscellaneous Services 562 Laboratory Considerations 65Part IB Common Elements of Renovations 1093 Renovations: Building Considerations 1233.1 Guiding Concepts 1233.2 Building Layout 1253.3 Heating Ventilating and Air-Conditioning Systems 1293.4 Loss Prevention Industrial Hygiene and Personal Safety 1333.5 Miscellaneous Services 1344 Renovations: Laboratory Considerations 1364.1 Guiding Concepts 1364.2 Laboratory Layout 1374.3 Heating Ventilating and Air-Conditioning Systems 1384.4 Loss Prevention Industrial Hygiene and Personal Safety 138Part II Design Guidelines for a Number of Commonly Used Laboratories 1415 General or Analytical Chemistry Laboratory 1435.1 Description 1435.2 Laboratory Layout 1445.3 Heating Ventilating and Air-Conditioning 1465.4 Loss Prevention Industrial Hygiene and Personal Safety 1495.5 Special Requirements 1496 High-Toxicity Laboratory 1506.1 Description 1506.2 Laboratory Layout 1516.3 Heating Ventilating and Air-Conditioning 1536.4 Loss Prevention Industrial Hygiene and Personal Safety 1546.5 Special Requirements 1557 Nanotechnology Laboratories 1567.1 Description 1567.2 Laboratory Layout 1567.3 Heating Ventilating and Air-Conditioning 1577.4 Loss Prevention Industrial Hygiene and Personal Safety 1588 Engineering Laboratories 1608.1 Description 1608.2 Engineering Disciplines and Some of Their Most Common Laboratory Types 1608.3 Wind Tunnel Laboratory 1618.4 Jet and Rocket Propulsion Laboratory 1628.5 Hydraulics Laboratory 1648.6 Material Analysis and Testing Laboratory 1658.7 Electrical Circuits Motors and Generators Laboratory 1658.8 Foundry Laboratory 1678.9 Internal Combustion and Gas Turbine Engine Laboratory 1699 Pilot Plant: Chemical Engineering and Biological 1739.1 Description 1739.2 Pilot Plant Layout 1749.3 Heating Ventilating and Air-Conditioning 1749.4 Loss Prevention Industrial Hygiene and Personal Safety 1759.5 Special Requirements 17510 Physics Laboratory 17710.1 Description 17710.2 Laboratory Layout 17810.3 Heating Ventilating and Air-Conditioning 17910.4 Loss Prevention Industrial Hygiene and Personal Safety 17910.5 Special Requirements 18111 Controlled Environment Room: Hot or Cold 18211.1 Description 18211.2 Laboratory Layout 18311.3 Heating Ventilating and Air-Conditioning 18311.4 Loss Prevention 18511.5 Special Requirements 18512 High-Pressure Laboratory 18712.1 Description 18712.2 Laboratory Layout 18812.3 Heating Ventilating and Air-Conditioning 18812.4 Loss Prevention Industrial Hygiene and Personal Safety 18912.5 Special Requirements 18913 Radiation Laboratory 19013.1 Description 19013.2 Laboratory Layout 19113.3 Heating Ventilating and Air-Conditioning 19413.4 Loss Prevention Industrial Hygiene and Personal Safety 19513.5 Special Considerations 19514 Biosafety Laboratory 19614.1 Description 19614.2 Laboratory Layout 20214.3 Heating Ventilating and Air-Conditioning 21214.4 Loss Prevention Industrial Hygiene and Personal Safety 21314.5 Special Requirements 21315 Clinical Laboratories 21615.1 Description 21615.2 Laboratory Layout 21815.3 Heating Ventilating and Air-Conditioning 22215.4 Loss Prevention Industrial Hygiene and Personal Safety 22316 Teaching Laboratory 22716.1 Description 22716.2 Laboratory Layout 22816.3 Heating Ventilating and Air-Conditioning 23416.4 Loss Prevention Industrial Hygiene and Personal Safety 23517 Gross Anatomy Laboratory 23817.1 Description 23817.2 Laboratory Layout 23917.3 Heating Ventilating and Air-Conditioning 24317.4 Loss Prevention Industrial Hygiene and Personal Safety 24417.5 Security 24518 Pathology Laboratory 24618.1 Description 24618.2 Laboratory Layout 24918.3 Heating Ventilating and Air-Conditioning 25118.4 Loss Prevention Industrial Hygiene and Personal Safety 25118.5 Special Requirements 25219 Autopsy Laboratory 25319.1 Description 25319.2 Laboratory Layout 25519.3 Heating Ventilating and Air-Conditioning 26019.4 Loss Prevention Industrial Hygiene and Personal Safety 26120 Morgue Facility 26220.1 Description 26220.2 Laboratory Layout 26520.3 Heating Ventilating and Air-Conditioning 26920.4 Loss Prevention Industrial Hygiene and Personal Safety 26921 Open or Team Research Laboratory 27121.1 Description 27121.2 Laboratory Layout 27221.3 Heating Ventilating and Air-Conditioning 27521.4 Loss Prevention Industrial Hygiene and Personal Safety 27521.5 Special Considerations 27622 Animal Research Laboratory 27722.1 Description 27722.2 Laboratory Layout 27922.3 Heating Ventilating and Air-Conditioning 29222.4 Loss Prevention Industrial Hygiene and Personal Safety 29622.5 Special Requirements 29723 Microelectronics and Cleanroom Laboratories 29923.1 Description 29923.2 Laboratory Layout 30323.3 Heating Ventilating and Air Conditioning 30723.4 Loss Prevention Industrial Hygiene and Personnel Safety 31023.5 Special Requirements 31223.6 Renovations 31424 Printmaking Studio 31524.1 Description 31524.2 Print Studio Layout 31724.3 Heating Ventilating and Air-Conditioning 31824.4 Loss Prevention Industrial Hygiene and Personal Safety 321Part III Laboratory Support Services 32525 Imaging and Photographic Facilities 32725.1 Introduction 32725.2 Photographic And Imaging Facility Layouts 33125.3 Heating Ventilating and Air-Conditioning 33425.4 Loss Prevention Industrial Hygiene and Personal Safety 33625.5 Special Requirements 33726 Support Shops 33926.1 Description 33926.2 Layout 34026.3 Heating Ventilating and Air-Conditioning 34426.4 Loss Prevention Industrial Hygiene and Personal Safety 34626.5 Special Requirements 34627 Hazardous Chemical Radioactive and Biological Waste-Handling Rooms 34827.1 Guiding Concepts 34827.2 Layout 35127.3 Heating Ventilating and Air-Conditioning 35627.4 Loss Prevention Industrial Hygiene and Personal Safety 35827.5 Special Requirements 35828 Laboratory Storerooms 36028.1 Description 36028.2 Layout 36328.3 Heating Ventilating and Air-Conditioning 36628.4 Loss Prevention Industrial Hygiene and Personal Safety 36728.5 Special Requirements 368Part IV Hvac Systems 36929 HVAC Systems 37129.1 Description 37129.2 Air-Conditioning Systems 37129.3 HVAC System Design and Description 37629.4 System Descriptions and Strategies 37729.5 Humidification and Dehumidification 38629.6 Space Pressure Control 38929.7 Automatic Control System 39130 Fans 39230.1 Fan Terminology 39230.2 Exhaust Fan Specifications 39330.3 Atmospheric Dispersion 39430.4 Fan Laws 39430.5 Fan Selection 39530.6 Fan Performance 39631 Air Cleaning 39731.1 Introduction 39731.2 Air-Cleaning Equipment for Laboratories 39832 Laboratory Hoods and Other Exhaust Air Contaminant-Capture Facilities and Equipment 40432.1 Introduction 40432.2 Conventional Bypass Chemical Fume Hoods 40532.3 Auxiliary Air Chemical Fume Hoods 40932.4 Perchloric Acid Fume Hoods 41132.5 Hoods for Work With Radioactive Materials 41132.6 Variable Air-Volume Hoods 41132.7 High-Performance Hoods 41232.8 Gloveboxes 41232.9 Biological Safety Cabinets 41332.10 Capture (Exterior) Hoods 41632.11 Ductless Hoods 41632.12 Performance Tests 42033 Exhaust Air Ducts and Accessories 42233.1 Introduction 42233.2 Exhaust Duct Considerations 42333.3 Exhaust System Classification 42433.4 Duct Accessories 42434 Variable-Air-Volume Systems 42634.1 Introduction 42634.2 VAV Hoods 42734.3 Good Design Practices for Vav Systems 42834.4 Variable-Volume Exhaust System Operational Concept 42834.5 VAV System Controls and Components 42934.6 VAV System Fan Controls and Components 43134.7 VAV System Duct Configurations 43435 Energy Conservation 43635.1 Introduction 43635.2 Recent Trends 43735.3 Exhaust Ventilation for Contamination Control 44035.4 Lighting 44835.5 Thermal Insulation 44835.6 Humidity Control 44835.7 Evaporative Cooling 44935.8 Water Conservation 44935.9 Efficient Operating Strategies 449Part V Administrative Procedures 45136 Project Execution and Bidding Procedures 45336.1 Guiding Concepts 45336.2 Implementation 45436.3 Bid Form 45636.4 Contract 45736.5 Change Orders 45736.6 Construction Inspections 45836.7 Punch List 45836.8 Additional Testing and Acceptance 45836.9 Beneficial Occupancy 45936.10 Final Acceptance and Commissioning 45937 Commissioning and Final Acceptance Criteria 46037.1 Guiding Concepts 46037.2 Design Construction and Preoccupancy Checklists 46037.3 Heating Ventilating and Air-Conditioning 46237.4 Loss Prevention Industrial Hygiene and Personal Safety 46637.5 Project Commissioning 46738 Sustainable Laboratory Design 47138.1 Introduction 47138.2 Laboratory Construction Materials 47238.3 Heating Ventilating and Air-Conditioning 47438.4 Loss Prevention Industrial Hygiene and Personal Safety 47738.5 Miscellaneous Services 47738.6 Lighting 47838.7 Submetering 47938.8 Additional Background Material 479Part VI Appendixes 481Appendix A Emergency Showers 483Appendix B Emergency Eyewash Units 485Appendix c Signs 486Appendix D Stack Design 489Appendix E Matrix of Building Consideration for Specific Laboratory Types 495References 500Index 509