CHARLES S. SELL, PHD, has recently retired from Givaudan after thirty-six years in the fragrance industry. His work has covered all aspects of synthetic organic chemistry as applied to the fragrance industry, from discovery of novel materials through process R&D to improvement of established chemical manufacturing processes. His interest in the design of novel fragrance ingredients, coupled with a long-standing interest in the chemistry of living organisms, led to a deepened investigation into olfaction.

“I cannot recommend this fascinating book highly enough.” (Simon Cotton, Chemistry & Industry,  September 2014)  “In conclusion: A comprehensive introduction to the world of odours, not only for chemists.” (review in German: Monika Paduch, Gefahrstoffe - Reinhaltung Luft, October 2014)

• Preface vii Acknowledgments ixIntroduction 11 Why Do We Have a Sense of Smell? 42 The Mechanism of Olfaction 323 Analysis and Characterisation of Odour 1884 The Sense of Smell in Our Lives 2095 The Scents of Nature 2376 Manufacture of Fragrance Ingredients 2967 The Design of New Fragrance Ingredients 3578 The Relationship Between Molecular Structure and Odour 3889 Intellectual Challenges in Fragrance Chemistry and the Future 420Glossary 428Index 437

CHARLES S. SELL, PHD, has recently retired from Givaudan after thirty-six years in the fragrance industry. His work has covered all aspects of synthetic organic chemistry as applied to the fragrance industry, from discovery of novel materials through process R&D to improvement of established chemical manufacturing processes. His interest in the design of novel fragrance ingredients, coupled with a long-standing interest in the chemistry of living organisms, led to a deepened investigation into olfaction.

“I cannot recommend this fascinating book highly enough.” (Simon Cotton, Chemistry & Industry,  September 2014)  “In conclusion: A comprehensive introduction to the world of odours, not only for chemists.” (review in German: Monika Paduch, Gefahrstoffe - Reinhaltung Luft, October 2014)

• Preface vii Acknowledgments ixIntroduction 11 Why Do We Have a Sense of Smell? 42 The Mechanism of Olfaction 323 Analysis and Characterisation of Odour 1884 The Sense of Smell in Our Lives 2095 The Scents of Nature 2376 Manufacture of Fragrance Ingredients 2967 The Design of New Fragrance Ingredients 3578 The Relationship Between Molecular Structure and Odour 3889 Intellectual Challenges in Fragrance Chemistry and the Future 420Glossary 428Index 437

CHARLES S. SELL, PHD, has recently retired from Givaudan after thirty-six years in the fragrance industry. His work has covered all aspects of synthetic organic chemistry as applied to the fragrance industry, from discovery of novel materials through process R&D to improvement of established chemical manufacturing processes. His interest in the design of novel fragrance ingredients, coupled with a long-standing interest in the chemistry of living organisms, led to a deepened investigation into olfaction.

“I cannot recommend this fascinating book highly enough.” (Simon Cotton, Chemistry & Industry,  September 2014)  “In conclusion: A comprehensive introduction to the world of odours, not only for chemists.” (review in German: Monika Paduch, Gefahrstoffe - Reinhaltung Luft, October 2014)

• Preface vii Acknowledgments ixIntroduction 11 Why Do We Have a Sense of Smell? 42 The Mechanism of Olfaction 323 Analysis and Characterisation of Odour 1884 The Sense of Smell in Our Lives 2095 The Scents of Nature 2376 Manufacture of Fragrance Ingredients 2967 The Design of New Fragrance Ingredients 3578 The Relationship Between Molecular Structure and Odour 3889 Intellectual Challenges in Fragrance Chemistry and the Future 420Glossary 428Index 437