Transplantation at a Glance

Menna Clatworthy is at the University of Cambridge and Addenbrooke's Hospital. Christopher Watson is at the School of Clinical Medicine, University of Cambridge.Michael Allison is at Cambridge University Hospitals NHS Foundation Trust.John Dark is Professor of Cardiothoracic Surgery at the Regional Cardiothoracic Centre, The Freeman Hospital, Newcastle upon Tyne.

“This is one of the best reviews of transplantation I have had the pleasure of reading. With its thorough collection of topics and its illustrations, it is a definite must read for those who are starting their training or spending a limited amount of time on a transplant service.” (Doody’s, 19 April 2013) This is a superbly produced small book with marvellous illustrations, and I am literally amazed how much information is presented in approximately 100 pages. The illustrations have been very carefully done and enhance the explanations in the text extremely well. The chapters range from a history of transplantation through organ donation and preservation; the immunology of organ transplantation; immunosuppression; complications of immunosuppression, and kidney, pancreas, liver, intestinal, and lung transplantations, finishing up with brief reviews of composite tissue transplantation and xenotransplantation.This is the ideal book to give to nurses or residents rotating through a transplantation unit or to scientists working in tissue typing or microbiology and virology with an interest in transplantation. Obviously, for those who stay in the field, they will need more in-depth information from the larger texts, but as a starter book, I have seen nothing better than this extremely good presentation. Each transplantation unit should have half a dozen or so available for those I have referred to above. (Peter J. Morris , Transplantation journal, 2012)

• Preface 7List of abbreviations 81 History of transplantation 10Organ donors2 Diagnosis of death and its physiology 123 Deceased organ donation 144 Live donor kidney transplantation 165 Live donor liver transplantation 18Organ preservation6 Organ preservation 20Immunology of organ transplantation7 Innate immunity 228 Adaptive immunity and antigen presentation 249 Humoral and cellular immunity 26Histocompatibility in transplantation10 Tissue typing and HLA matching 2811 Detecting HLA antibodies 3012 Antibody-incompatible transplantation 32Organ allocation13 Organ allocation 34Immunosuppression14 Immunosuppression: induction vs maintenance 3615 Biological agents 3716 T cell-targeted immunosuppression 38Complications of immunosuppression17 Side effects of immunosuppressive agents 4018 Post-transplant infection 4219 CMV infection 4420 Post-transplant malignancy 46Kidney transplantation21 End-stage renal failure 4822 Complications of ESRF 5023 Dialysis and its complications 5224 Assessment for kidney transplantion 5425 Kidney transplantation: the operation 5626 Surgical complications of kidney transplantation 5827 Delayed graft function 6028 Transplant rejection 6229 Chronic renal allograft dysfunction 64Pancreas and islet transplantation30 Transplantation for diabetes mellitus 6631 Pancreas transplantation 6832 Islet transplantation 70Liver transplantation33 Causes of liver failure 7234 Assessment for liver transplantation 7435 Liver transplantation: the operation 7636 Complications of liver transplantation 78Intestinal transplantation37 Intestinal failure and assessment 8038 Intestinal transplantation 82Heart transplantation39 Assessment for heart transplantation 8440 Heart transplantation: the operation 8641 Complications of heart transplantation 88Lung transplantation42 Assessment for lung transplantation 9043 Lung transplantation: the operation 9244 Complications of lung transplantation 94Composite tissue transplantation45 Composite tissue transplantation 96Xenotransplantation46 Xenotransplantation 98Index 100Preface 7List of abbreviations 81 History of transplantation 10Organ donors2 Diagnosis of death and its physiology 123 Deceased organ donation 144 Live donor kidney transplantation 165 Live donor liver transplantation 18Organ preservation6 Organ preservation 20Immunology of organ transplantation7 Innate immunity 228 Adaptive immunity and antigen presentation 249 Humoral and cellular immunity 26Histocompatibility in transplantation10 Tissue typing and HLA matching 2811 Detecting HLA antibodies 3012 Antibody-incompatible transplantation 32Organ allocation13 Organ allocation 34Immunosuppression14 Immunosuppression: induction vs maintenance 3615 Biological agents 3716 T cell-targeted immunosuppression 38Complications of immunosuppression17 Side effects of immunosuppressive agents 4018 Post-transplant infection 4219 CMV infection 4420 Post-transplant malignancy 46Kidney transplantation21 End-stage renal failure 4822 Complications of ESRF 5023 Dialysis and its complications 5224 Assessment for kidney transplantion 5425 Kidney transplantation: the operation 5626 Surgical complications of kidney transplantation 5827 Delayed graft function 6028 Transplant rejection 6229 Chronic renal allograft dysfunction 64Pancreas and islet transplantation30 Transplantation for diabetes mellitus 6631 Pancreas transplantation 6832 Islet transplantation 70Liver transplantation33 Causes of liver failure 7234 Assessment for liver transplantation 7435 Liver transplantation: the operation 7636 Complications of liver transplantation 78Intestinal transplantation37 Intestinal failure and assessment 8038 Intestinal transplantation 82Heart transplantation39 Assessment for heart transplantation 8440 Heart transplantation: the operation 8641 Complications of heart transplantation 88Lung transplantation42 Assessment for lung transplantation 9043 Lung transplantation: the operation 9244 Complications of lung transplantation 94Composite tissue transplantation45 Composite tissue transplantation 96Xenotransplantation46 Xenotransplantation 98Index 100