Plasma Medicine

Alexander Fridman, Ph.D., Dr.Sci., is a Nyheim Chair Professor and director of the A.J. Drexel Plasma Institute, working on new plasma approaches to material treatment, fuel conversion, environmental control and bio-medical applications. He is one the pioneers of Plasma Medicine, President of the International Society on plasma Medicine. Dr. Fridman is author of six books and over 450 publications in scientific journals. He has received numerous awards, including Stanley Kaplan Distinguished Professorship of University of Illinois and George Soros Distinguished Professorship in Physics, the DuPont research award, Chernobyl award, University of Illinois and Drexel University Outstanding Research awards, Kurchatov Gold Medal for Achievements in Science and Technology.Gary Friedman, PhD, is a Professor of Electrical Engineering as well as Professor of Surgery in Drexel University. He is Associate Director of the Drexel Plasma Institute, leading the direction of plasma medicine. He is a world renowned specialist in novel engineering methods in medicine, especially in plasma medicine. He is an author of pioneering works related to bio-physics and bio-chemistry of plasma interactions with living tissue. He made significant contribution in plasma applications for wound treatment. Dr. Gary Friedman also has extensive experience in modeling and design of magnetic devices.

• Preface xvAcknowledgements xvii1 Introduction to Fundamental and Applied Aspects of Plasma Medicine 11.1 Plasma medicine as a novel branch of medical technology 11.2 Why plasma can be a useful tool in medicine 41.3 Natural and man-made, completely and weakly ionized plasmas 51.4 Plasma as a non-equilibrium multi-temperature system 71.5 Gas discharges as plasma sources for biology and medicine 91.6 Plasma chemistry as the fundamental basis of plasma medicine 131.7 Non-thermal plasma interaction with cells and living tissues 141.8 Applied plasma medicine 152 Fundamentals of Plasma Physics and Plasma Chemistry for Biological and Medical Applications 192.1 Elementary plasma generation processes 192.2 Excited species in plasma medicine: Excitation, relaxation and dissociation of neutral particles in plasma 312.3 Elementary plasma-chemical reactions of excited neutrals and ions 392.4 Plasma statistics, thermodynamics, and transfer processes 462.5 Plasma kinetics: Energy distribution functions of electrons and excited atoms and molecules 582.6 Plasma electrodynamics 683 Selected Concepts in Biology and Medicine for Physical Scientists 813.1 Molecular basis of life: Organic molecules primer 813.2 Function and classification of living forms 963.3 Cells: Organization and functions 973.4 Overview of anatomy and physiology 1244 Major Plasma Disharges and their Applicability for Plasma Medicine 1654.1 Electric breakdown and steady-state regimes of non-equilibrium plasma discharges 1654.2 Glow discharge and its application to biology and medicine 1774.3 Arc discharge and its medical applications 1914.4 Radio-frequency and microwave discharges in plasma medicine 2084.5 Coronas, DBDs, plasma jets, sparks and other non-thermal atmospheric-pressure streamer discharges 2324.6 Discharges in liquids 2535 Mechanisms of Plasma Interactions with Cells 2695.1 Main interaction stages and key players 2695.2 Role of plasma electrons and ions 2725.3 Role of UV, hydrogen peroxide, ozone and water 2765.4 Biological mechanisms of plasma interaction for mammalian cells 2816 Plasma Sterilization of Different Surfaces and Living Tissues 2936.1 Non-thermal plasma surface sterilization at low pressures 2936.2 Surface microorganism inactivation by non-equilibrium high-pressure plasma 2956.3 Plasma species and factors active for sterilization 3046.4 Physical and biochemical effects of atmospheric-pressure air plasma on microorganisms 3136.5 Animal and human living tissue sterilization 3206.6 Generated active species and plasma sterilization of living tissues 3246.7 Deactivation/destruction of microorganisms due to plasma sterilization: Are they dead or just scared to death? 3297 Plasma Decontamination ofWater and Air Streams 3397.1 Non-thermal plasma sterilization of air streams 3397.2 Direct and indirect effects in non-thermal plasma deactivation of airborne bacteria 3477.3 Non-thermal plasma in air-decontamination: Air cleaning from SO2 and NOx 3537.4 Non-thermal plasma decontamination of air from volatile organic compound (VOC) emissions 3617.5 Plasma desinfection and sterilization of water 3788 Plasma Treatment of Blood 3898.1 Plasma-assisted blood coagulation 3898.2 Effect of non-thermal plasma on improvement of rheological properties of blood 3959 Plasma-assisted Healing and Treatment of Diseases 4039.1 Wound healing and plasma treatment of wounds 4039.2 Treatment of inflammatory dysfunctions 4189.3 Plasma treatment of cancer 4229.4 Plasma applications in dentistry 4289.5 Plasma surgery 43310 Plasma Pharmacology 43510.1 Non-thermal plasma treatment of water 43510.2 Deionized water treatment with DBD in different gases: Experimental setup 43610.3 Deionized water treatment with DBD in different gases: Results and discussion 43810.4 Enhanced antimicrobial effect due to organic components dissolved in water 44210.5 Summary 44611 Plasma-assisted Tissue Engineering and Plasma Processing of Polymers 44711.1 Regulation of biological properties of medical polymer materials 44711.2 Plasma-assisted cell attachment and proliferation on polymer scaffolds 44811.3 Plasma-assisted tissue engineering in control of stem cells and tissue regeneration 45111.4 Plasma-chemical polymerization of hydrocarbons and formation of thin polymer films 45311.5 Interaction of non-thermal plasma with polymer surfaces 461References 483Index 497