Dr. Richard Lockshin's doctoral thesis introduced the term and concept of programmed cell death, and his laboratory has been involved in several of the major advances in the field. Following his training at Harvard, he completed his postdoctoral training at the University of Edinburgh, and subsequently taught at the University of Rochester School of Medicine and Dentistry and St. John's University, where he is Professor of Biology. He has well over 100 publications on the subject, including five books. He has won several prizes for his work and has held several scientific offices, including the founding chair of the Gordon Conferences on Cell Death, and co-founder and first president of the International Cell Death Society. Dr. Zahra Zakeri was originally trained as a geneticist and virologist and, following her post-doctoral training at Columbia University, working on germ cell development, embarked on the study of apoptosis. She has been a leader in the development of many ideas in the field, including identification of the correlation between the synthesis of growth factors and cell death, the role of cell death in congenital malformations, measurement of DNA fragmentation in situ, recognition of the role of lysosomes and macrophages in cell death and its measurement, and the relationship of cell cycle to cell death. She was a cofounder of the Gordon Conferences on Cell Death and the International Cell Death Society, of which she is currently President. She has been a featured speaker in more than 20 countries.

"...thoughtfully edited and readable. The book illustrates the importance of apoptosis in development, homeostasis, and human disease...an important contribution to the literature." (Doody's Book Review Service) "…thoroughly researched, highly readable, and informative." (E-STREAMS, March 2005)

• Contributors viiPreface xiSection I Cell Death Origin and Progression1 Introduction 3Richard A. Lockshin and Zahra ZakeriSection II Biological Role of Cell Death in Development and Homeostasis2 Cell Death: Shaping an Embryo 27Zahra Zakeri and Richard A. Lockshin3 Cell Death in Dictyostelium: Assessing a Genetic Approach 59Jean-Pierre Levraud, Myriam Adam, Marie-Françoise Luciani, Laurence Aubry, Gérard Klein, and Pierre Golstein4 Programmed Cell Death in Drosophila Melanogaster 79Loretta Dorstyn and Sharad Kumar5 Cell Death in Plant Development and Defense 99Ron Mittler and Alice Y. Cheung6 Regulation of Apoptosis by Extracellular Matrix During Postembryonic Development in Xenopus Laevis 123Atsuko Ishizuya-Oka, Tosikazu Amano, Liezhen Fu, and Yun-Bo Shi7 Apoptosis in the Immune System 143Alexandra Brás, David García-Domingo, and Carlos Martinez-A.8 Cell Death in Neuronal Development and Maintenance 175Aviva M. Tolkovsky, Edward T. W. Bampton, and Cristoph G. Goemans9 Cell Turnover: Intestine and other Tissues 201James W. Wilson and Christopher S. Potten10 Cell Death, Aging Phenotypes, and Models of Premature Aging 241Huber R. WarnerSection III How Cell Death Is Carried Out11 Survival Factors 257David L. Vaux12 Caspase-independent and Autophagic Programmed Cell Death 275Wilfried Bursch, Adolf Ellinger, Christopher Gerner, and Rolf Schulte-Hermann13 The Recognition and Engulfment of Apoptotic Cells by Phagocytes 311Raymond B. Birge14 Cell Cycle Genes: pRb and P53 339Nianli Sang and Antonio Giordano15 Mitochondria and Oxidation in the Regulation of Cell Death 381John D. Robertson, Sten Orrenius, and Boris ZhivotovskySection IV Deregulation of Cell Death in Disease and Future Intervention16 the Use of Proteomics to Identify and Characterize Cell Death Proteins 405Xavier Saelens, Geert van Loo, Kris Gevaert, Joel Vanderkerckhove, and Peter Vandenabeele17 Cell Death in Viral Infections, 435Ying-bei Chen, Yihru Fannjiang, and J. Marie Hardwick18 Cell Death in Cancer and Cancer Therapy 461Simone Fulda and Klaus-Michael Debatin19 the Role of Apoptosis in Myocardial Infarction and Heart Failure 483Kartik Mani, Chang-Fu Peng, Gregg Rosner, and Richard N. KitsisIndex 521

Dr. Richard Lockshin's doctoral thesis introduced the term and concept of programmed cell death, and his laboratory has been involved in several of the major advances in the field. Following his training at Harvard, he completed his postdoctoral training at the University of Edinburgh, and subsequently taught at the University of Rochester School of Medicine and Dentistry and St. John's University, where he is Professor of Biology. He has well over 100 publications on the subject, including five books. He has won several prizes for his work and has held several scientific offices, including the founding chair of the Gordon Conferences on Cell Death, and co-founder and first president of the International Cell Death Society. Dr. Zahra Zakeri was originally trained as a geneticist and virologist and, following her post-doctoral training at Columbia University, working on germ cell development, embarked on the study of apoptosis. She has been a leader in the development of many ideas in the field, including identification of the correlation between the synthesis of growth factors and cell death, the role of cell death in congenital malformations, measurement of DNA fragmentation in situ, recognition of the role of lysosomes and macrophages in cell death and its measurement, and the relationship of cell cycle to cell death. She was a cofounder of the Gordon Conferences on Cell Death and the International Cell Death Society, of which she is currently President. She has been a featured speaker in more than 20 countries.

"...thoughtfully edited and readable. The book illustrates the importance of apoptosis in development, homeostasis, and human disease...an important contribution to the literature." (Doody's Book Review Service) "…thoroughly researched, highly readable, and informative." (E-STREAMS, March 2005)

• Contributors viiPreface xiSection I Cell Death Origin and Progression1 Introduction 3Richard A. Lockshin and Zahra ZakeriSection II Biological Role of Cell Death in Development and Homeostasis2 Cell Death: Shaping an Embryo 27Zahra Zakeri and Richard A. Lockshin3 Cell Death in Dictyostelium: Assessing a Genetic Approach 59Jean-Pierre Levraud, Myriam Adam, Marie-Françoise Luciani, Laurence Aubry, Gérard Klein, and Pierre Golstein4 Programmed Cell Death in Drosophila Melanogaster 79Loretta Dorstyn and Sharad Kumar5 Cell Death in Plant Development and Defense 99Ron Mittler and Alice Y. Cheung6 Regulation of Apoptosis by Extracellular Matrix During Postembryonic Development in Xenopus Laevis 123Atsuko Ishizuya-Oka, Tosikazu Amano, Liezhen Fu, and Yun-Bo Shi7 Apoptosis in the Immune System 143Alexandra Brás, David García-Domingo, and Carlos Martinez-A.8 Cell Death in Neuronal Development and Maintenance 175Aviva M. Tolkovsky, Edward T. W. Bampton, and Cristoph G. Goemans9 Cell Turnover: Intestine and other Tissues 201James W. Wilson and Christopher S. Potten10 Cell Death, Aging Phenotypes, and Models of Premature Aging 241Huber R. WarnerSection III How Cell Death Is Carried Out11 Survival Factors 257David L. Vaux12 Caspase-independent and Autophagic Programmed Cell Death 275Wilfried Bursch, Adolf Ellinger, Christopher Gerner, and Rolf Schulte-Hermann13 The Recognition and Engulfment of Apoptotic Cells by Phagocytes 311Raymond B. Birge14 Cell Cycle Genes: pRb and P53 339Nianli Sang and Antonio Giordano15 Mitochondria and Oxidation in the Regulation of Cell Death 381John D. Robertson, Sten Orrenius, and Boris ZhivotovskySection IV Deregulation of Cell Death in Disease and Future Intervention16 the Use of Proteomics to Identify and Characterize Cell Death Proteins 405Xavier Saelens, Geert van Loo, Kris Gevaert, Joel Vanderkerckhove, and Peter Vandenabeele17 Cell Death in Viral Infections, 435Ying-bei Chen, Yihru Fannjiang, and J. Marie Hardwick18 Cell Death in Cancer and Cancer Therapy 461Simone Fulda and Klaus-Michael Debatin19 the Role of Apoptosis in Myocardial Infarction and Heart Failure 483Kartik Mani, Chang-Fu Peng, Gregg Rosner, and Richard N. KitsisIndex 521