Epilepsy

"...covers a broad spectrum of important issues and concepts and should stimulate discussion among clinical epidemiologists and basic scientists interested in the pathophysiology of epilepsy...a lucid, well thought out review of many of the major issues in epilepsy research and much of the progress that has been made over the past few decades. I highly recommend this volume." J.H. Schneiderman, The Canadian Journal of Neurological Sciences

• List of contributors; General introduction Philip A. Schwartzkroin; Part I. Chronic Models in Intact Animals - Concepts and Questions: Introduction; 1. The kindling model of epilepsy James O. McNamara, Douglas W. Bonhaus and Cheolsu Shin; 2. Focal trigger zones and pathways of propagation in seizure generation Karen Gale; 3. Genetic models of the epilepsies Phillip C. Jobe, Pravin K. Mishra, Nandor Ludvig and John W. Dailey; 4. Noradrenergic modulation of excitability: transplantation approaches to epilepsy research Olle Lindvall; 5. Sensitivity of the immature central nervous system to epileptogenic stimuli Solomon L. Moshé, Patric K. Stanton and Ellen F. Sperber; Part II. Features of the Epileptogenic Brain: Introduction; 6. Neurophysiological studies of alterations in seizure susceptibility during brain development John. W. Swann, Karen L. Smith, Robert J. Brady and Martha G. Pierson; 7. Electrophysiology and pharmacology of human neocortex and hippocampus in vitro Massimo Avoli; 8. Cell death, plasticity and epilepsy: insights provided by experimental models of hippocampal sclerosis JoAnn E. Franck; 9. Sprouting as an underlying cause of hyperexcitability in experimental models and in the human epileptic temporal lobe Thomas P. Sutula; 10. Rapidly recurring seizures and status epilepticus: ictal density as a factor in epileptogenesis Eric W. Lothman, Janet L. Stringer and Edward H. Bertram; Part III. 'Normal' Brain Mechanisms That Support Epileptiform Activities: Introduction; 11. Brain slice models for the study of seizures and interictal spikes Wilkie A. Wilson and Andrew Bragdon; 12. Generation of epileptiform discharge by local circuits of neocortex Barry W. Connors and Yael Amitai; 13. Study of GABAergic inhibition and GABAA receptors in experimental epilepsy Robert K. S. Wong and Richard Miles; 14. High potassium-induced synchronous bursts and electrographic seizures Christopher J. McBain, Stephen F. Traynelis and Raymond Dingledine; 15. Anti-epileptic effects of organic calcium channel blockers in animal experiments Erwin-Josef Speckmann and Jörg Walden; Recent advances; Index.