Jong M. Rho, Unibersity of California at Irvine College of Medicne,USA. Raman Sankar, University of California. Los Angeles, US. Jose E. Cavazos, University of Texas Health Center at San Antonio, USA.

"…Libraries that serve medical professionals should have this book. Any university library supporting programs in medicine should also have this book….this book fills a niche unfilled by other books in its specificity towards epilepsy research."-E-Streams

• 1. Introduction Part I: Scientific Foundations 2. Pathophysiology of Seizures and Epilepsy 3. Drug Resistance in Epilepsy and Status Epilepticus 4. Genetics of Human Epilepsy—Epilepsy as a Channelopathy Part II: Antiepileptic Drugs 5. Ontogeny of Molecular Targets of Antiepileptic Drugs: Impact on Drug Choice 6. Epilepsy and Disease Modification: Animal Models for Novel Drug Discovery 7. Nonsynaptic Mechanisms in Seizures and Epileptogenesis: Targets for Clinical Management? 8. A Mechanistic Approach to Antiepileptic Drug Interactions 9. Toxicology of Idiosyncratic Organ Toxicities of AEDs Part III: Epilepsy Surgery 10. Advances in Structural and Functional Neuroimaging: How Are These Guiding Epilepsy Surgery? 11. Magnetoencephalography in Clinical Epilepsy 12. Nonsurgical Ablation of Epileptic Tissue Part IV: Alternative Therapies 13. Special Treatments in Epilepsy 14. The Ketogenic Diet: Scientific Principles Underlying Its Use 15. Vagus Nerve Stimulation 16. Immunomodulation of Epilepsy 17 Neurosteroids: Endogenous Modulators of Seizure Susceptibility Part V: Other Modulators of the Epileptic State 18. Impact of Neuroendocrine Factors on Seizure Genesis and Treatment 19. Chronobiology and Sleep: Implications for Seizure Propensity 20. Psychopathology in Epilepsy: A Window to Brain Behavior Relationships Part VI: The Future of Epilepsy Therapy 21. Novel Mechanisms of Drug Delivery 22. Deep Brain Stimulation: Why Should This Work? 23. Intraoperative Optical Imaging of Epileptiform and Functional Activity 24. Early Seizure Detection: Theoretical and Applied 25. Arresting Epileptogenesis: The Current Challenge