Multiscale Modeling of the Skeletal System

Inbunden, Engelska, 2011

1 675 kr

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Beskrivning

Integrative approaches to biomedical research promise to advance our understanding of the human body and physiopathology of diseases. In this book, the author focuses on the skeletal system, demonstrating how multiscale modeling can determine the relationship between bone mechanics and disease. Introductory chapters explain the concept of integrative research, what a model is, predictive modeling, and the computational methods used throughout the book. Starting with whole body anatomy, physiology and modeling, subsequent chapters scale down from bone and tissue levels to the cellular level, where the modeling of mechanobiological processes is addressed. Finally, the principles are applied to address truly complex, multiscale interactions. Special attention is given to real-world clinical applications: one in pediatric skeletal oncology and one on the prediction of fracture risks in osteoporotic patients. This book has wide interdisciplinary appeal and is a valuable resource for researchers in mechanical and biomedical engineering, quantitative physiology and computational biology.

Produktinformation

Utgivningsdatum:2011-12-15
Mått:181 x 255 x 16 mm
Vikt:600 g
Format:Inbunden
Språk:Engelska
Antal sidor:222
Förlag:Cambridge University Press
ISBN:9780521769501

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Mer om författaren

Marco Viceconti is a world expert in the computational modeling of musculoskeletal systems. The primary driving force behind the Virtual Physiological Human (VPH) Initiative, which aims to develop the methods and technologies to make possible the dream of systems biology, physiome and systems medicine, he is currently the Director of the VPH Institute, the international no-profit organisation that drives the VPH Initiative.

Recensioner i media

'Professor Viceconti is one of the pioneers of the integrative approach to biological systems and his book is a beautiful illustration of this approach. Beautiful in all senses: sound intellectual argument, clear informative illustrations, fascinating practical applications, and it forms a sustained development of a field of research that is fundamental to the success of any attempt to create the Virtual Physiological Human.' Denis Noble, University of Oxford

Innehållsförteckning

1. Introduction; 2. Methodological aspects; 3. The body level; 4. Organ level: the bones; 5. Tissue level: mineralised extracellular matrix; 6. Cells level: cells-matrix interaction; 7. Applications of multiscale modeling; 8. Multiscale modeling; Index.