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Beskrivning
This text presents a review of new approaches and techniques employed in radiopharmaceutical development. It provides researchers with an insight into the ideas of a number of internationally known experts from reviews in their recognized areas of expertise and describes new tools which can be applied in the analysis and evaluation of these new tracers. The book should be invaluable to anyone involved or interested in the development of new radiopharmaceuticals.
' ... very good reference text ... a very useful book, especially as an aid to teachers or in providing an overall picture of fast developing new didrections in radiopharmaceutical research.' ANZ Nuclear Medicine, 23 (1997)
Innehållsförteckning
1. Radiopharmaceutically relevant chemistry of technetium and rhenium..- 2. Bifunctional chelators for Tc-99m.- 3. Medium half-life inorganic radionuclides for PET imaging.- 4. Therapeutic radionuclides: making the right choice..- 5. Radiopharmaceuticals for imaging hypoxia.- 6. Genetic engineering of monoclonal antibodies.- 7. The development of radiopharmaceuticals for imaging CNS receptors.- 8. Imaging the functions of the cell nucleus..- 9. Steroid hormone receptors as targets for diagnostic imaging.- 10. Radiolabelling oligonucleotides with imagable radionuclides.- 11. Radioligand binding assays: theory and practice.- 12. Molecular modelling: an introduction.- 13. Computer modelling of metal-based radiopharmaceuticals.- 14. Microautoradiography.