Solid-Phase Synthesis

A Practical Guide

Inbunden, Engelska, 2000

6 324 kr

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Beskrivning

This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates, conjugates of biomolecules, and small molecules.

Produktinformation

Utgivningsdatum:2000-04-28
Mått:152 x 229 x undefined mm
Vikt:1 730 g
Format:Inbunden
Språk:Engelska
Antal sidor:848
Förlag:Taylor & Francis Inc
ISBN:9780824703592

Utforska kategorier

Biokemi inom Naturvetenskap och teknik
Fysikalisk kemi inom Naturvetenskap och teknik
Biologi inom Naturvetenskap och teknik

Mer om författaren

Steven A. Kates, Fernando Albericio

Innehållsförteckning

The solid support strategy in solid-phase synthesis; amino acids -alpha-amino protecting groups; side-chain protecting groups; solid supports for the synthesis of peptides and small molecules; coupling methods - solid-phase formation of amide and ester bonds; homodetic cyclic peptides; disulfide formation in synthetic peptides and proteins -the state of the art; solid-phase convergent approaches to the synthesis of native peptides and proteins; preparation of glyco-, phospho-, and sulfopeptides; oligonucleotide synthesis; synthesis of oligonucleotide-peptide conjugates and nucleopeptides; the chemistry of peptide nucleic acids; solid-phase synthesis of pseudopeptides and oligomeric peptide backbone mimetics; instrumentation; the purification of synthetic peptides; analysis of synthetic peptides; the chromatographic analysis of combinational arrays - parallel HPLC and HPLC-MS.