Drug Metabolizing Enzymes

Cytochrome P450 and Other Enzymes in Drug Discovery and Development

Inbunden, Engelska, 2003

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Beskrivning

Critical in the elimination of drugs and other xenobiotics from the body, cytochrome P450 has strong bearing on scientific assessments of genetic polymorphism in metabolism, possible drug-drug interactions, and bioavailability of candidate drugs. This text systematizes findings on P450 and similar enzymes - as well as parallel issues shaping the pharmaceutical industry - to promote the next generation of safer, more effective drugs.

Produktinformation

Utgivningsdatum:2003-09-03
Mått:156 x 234 x 35 mm
Vikt:1 076 g
Format:Inbunden
Språk:Engelska
Antal sidor:608
Förlag:Taylor & Francis Inc
ISBN:9780824742935

Utforska kategorier

Farmakologi inom Medicin
Tillverkningsteknik inom Naturvetenskap och teknik

Mer om författaren

Jae Lee, R. Scott Obach, Michael B. Fisher

Innehållsförteckning

Dioxygen activation by cytochromes P450 - a role for multiple oxidants in the oxidation of substrates, Alfin D.N. Vaz; application of LC/MS, LC/NMR, NMR and stable isotopes in identifying and characterizing metabolites, A.E. Mutlib and John P. Shockcor; bioactivation, Jack Uetrecht; chemically reactive metabolites in drug discovery and development, Thomas A. Baillie; cytochrome P450 and its place in drug discovery and development, Dennis Smith; cytochrome P450 in laboratory animal species, Margit Spatzenegger, Stephanie L. Born and James R. Halpert; typical and atypical enzyme, Kinetics J. Brian Houston, Kathryn E. Kenworthy and Aleksandra Galetin; cytochrome P450 reaction phenotyping, Larry C. Wienkers and Jeffrey C. Stevens; drug-drug interactions and the cytochromes P450, Kenneth A. Bachmann, Barbara J. Ring and Steven A. Wrighton; CYP gene induction by xenobiotics and drugs, Jean-Marc Pascussi, Sabine Gerbal-Chaloin, Martine Daujat, Lionel Drocourt, Lydiane Pichard-Garcia, Marie-Jose Vilarem, Patrick Maurel, Sylvie Klieber, Francois Torreilles, Martine Bourrie, Francois Guillou and Gerard Fabre; cytochrome P450 pharmacogenetics, Robert L. Haining and Aiming Yu; role of intestinal cytochromes P450 in drug deposition, Mary F. Paine and Kenneth E. Thummel; prediction of hepatic clearance in humans from experimental animals and in vitro data, Masato Chiba, Yoshihiro Shibata, Hiroyuki Takahashi, Yasuyuki Ishii and Yuichi Sugiyama; non-P450 mediated oxidative metabolism of xenobiotics, Dieter Lang and Amit S. Kalgutkar; the role of sulfotransferases (SULTs) and UDP-glucuronosyltransferases (UGTs) in human drug clearance and bioactivation, Michael W.H. Coughtrie and Michael B. Fisher.