Jaè Lee – författare

Critical in the elimination of drugs and other xenobiotics from the body, cytochrome P450 has strong bearing on scientific assessments of genetic polymorphism in metabolism, possible drug-drug interactions, and bioavailability of candidate drugs. This text systematizes findings on P450 and similar enzymes - as well as parallel issues shaping the pharmaceutical industry - to promote the next generation of safer, more effective drugs.

Critical in the elimination of drugs and other xenobiotics from the body, cytochrome P450 has strong bearing on scientific assessments of genetic polymorphism in metabolism, possible drug-drug interactions, and bioavailability of candidate drugs. This text systematizes findings on P450 and similar enzymes--as well as parallel issues shaping the pharmaceutical industry--to promote the next generation of safer, more effective drugs. Topics include dioxygen activation, the identification and characterization of metabolites, bioactivation, P450 in lab animal species, enzyme kinetics, reaction phenotyping, drug-drug interactions, pharmacogenetics, hepatic clearance, and the role of UGTs.

Critical in the elimination of drugs and other xenobiotics from the body, cytochrome P450 has strong bearing on scientific assessments of genetic polymorphism in metabolism, possible drug-drug interactions, and bioavailability of candidate drugs. This text systematizes findings on P450 and similar enzymes--as well as parallel issues shaping the pharmaceutical industry--to promote the next generation of safer, more effective drugs. Topics include dioxygen activation, the identification and characterization of metabolites, bioactivation, P450 in lab animal species, enzyme kinetics, reaction phenotyping, drug-drug interactions, pharmacogenetics, hepatic clearance, and the role of UGTs.

The O'Connell family (Lily - age 13; Tyler - age 11; and their parents) are vacationing in Ireland when they encounter an old man with a mysterious crystal that seemingly teleports them 1,000 years back in time. Unsure whether they have stumbled into a historical re-enactment, the family must befriend Rory, a timid local, battle a medieval tyrant named Ciaran and his henchmen, and figure out how to get back to the present, while Lily learns to use her newfound superpowers. From the writer/creator of Seven Sons, Robert Windom, and his eleven-year-old daughter, Lily, comes a fun, fantasy adventure. Featuring cover art by Jae Lee, as well as Art Direction and cover art by Sanford Greene (Bitter Root)--both Eisner-Award winning artists--and anime-inspired interior art by new talent and Greene-protege Asiah Fulmore (DC's Amethyst: Princess of Gemworld).