"…Structure-Based Drug Design is an outstanding source of knowledge, inspiration, and delight. It is also a resonant proof that drug researchers are particularly fortunate scientists, being able to both uncover and contemplate the boundless complexities of Nature, and to actualize their awe by contributing to general health and well-being."-Journal of Pharmaceutical Research"…the book is well-planned and executed, succeeding in giving the reader a fairly broad and complete overview of the many facets of structure based drug design."-Journal of Medicinal Chemistry

• AIDSInhibitors of HIV-1 Protease, Krzysztof AppeltA Review of Structural Studies of HIV-1 Reverse Transcriptase and Implications for Drug Design, Jianping Ding, Kalyan Das, Prem N. S. Yadav, Yu Hsiou, Wanyi Zhang, Stephen H. Hughes, and Edward ArnoldRetroviral Integrase: Structure as a Foundation for Drug Design, Alison B. Hickman and Fred DydaArthritis and InflammationBradykinin Receptor Antagonists, Donald J. KyleCancerDesign of Purine Nucleoside Phosphorylase Inhibitors, Y. Sudhakara Babu, John A. Montgomery, Charles E. Bugg, W. Michael Carson, Sthanam V. L. Narayana, William J. Cook, Steven E. Ealick, Wayne C. Guida, Mark Erion, and John Secrist IIIStructural Implications in the Design of Matrix-Metalloproteinase Inhibitors, John C. SpurlinoStructure - Function Relationships in Hydroxysteroid Dehydrogenases, Igor Tsigelny and Michael BakerDesign of ATP Competitive Specific Inhibitors of Protein Kinases Using Template Modeling, Janusz M. Sowadski, Charles A. Ellis, Rolf Karlsson, and MadhusudanDiabetes MellitisStructural Studies of Aldose Reductase Inhibition, David K. Wilson, J. Mark Petrash, and Florante A. QuiochoHeart DiseasesStructure-Based Design of Thrombin Inhibitors, Patricia C. Weber and Michael CzarnieckiDesign of Antithrombotic Agents Directed at Factor Xa, William C. RipkaPolypeptide Modulators of Sodium Channel Function as a Basis for the Development of Novel Cardiac Stimulants, Raymond S. NortonRational Design of Renin Inhibitors, V. Dhanaraj and J. B. CooperParkinson's DiseaseStructural Aspects in the Inhibitor Design of Catechol O-Methyltransferase, Jukka Vidgren and Martti OvaskaSleeping SicknessAntitrypanosomiasis Drug Development Based on Structures of Glycolytic Enzymes, Christopher L. M. J. Verlinde, Hidong Kim, Bradley E. Bernstein, Shekhar C. Mande, and Wim G. J. HolImmune Diseases and CytokinesProgress in the Design of Immunomodulators Based on the Structure of Interleukin-1, Glen Spraggon and Pandi VeerapandianStructure and Functional Studies of Interferon: A Solid Foundation for Rational Drug Design, Michael A. Jarpe, Carol H. Pontzer, Brian E. Szente, and Howard M. JohnsonAntiviralsThe Design of Anti-Influenza Virus Drugs from the X-Ray Molecular Structure of Influenza Virus Neuraminidase, Joseph N. VargheseRhinoviral Capsid-Binding Inhibitors: Structural Basis for Understanding Rhinoviral Biology and for Drug Design, Vincent L. Giranda and Guy D. DianaNovel MethodologiesThe Integration of Structure-Based Design and Directed Combinatorial Chemistry for New Pharmaceutical Discovery, Roger Bone and F. Raymond SalemmeStructure-Based Combinatorial Ligand Design, Amedeo Caflisch and Claus EhrhardtPeptidomimetic and Neopeptide Drug Discovery: Impact on Structure-Based Drug Design, Tomi K. Sawyer

"…Structure-Based Drug Design is an outstanding source of knowledge, inspiration, and delight. It is also a resonant proof that drug researchers are particularly fortunate scientists, being able to both uncover and contemplate the boundless complexities of Nature, and to actualize their awe by contributing to general health and well-being."-Journal of Pharmaceutical Research"…the book is well-planned and executed, succeeding in giving the reader a fairly broad and complete overview of the many facets of structure based drug design."-Journal of Medicinal Chemistry

• AIDSInhibitors of HIV-1 Protease, Krzysztof AppeltA Review of Structural Studies of HIV-1 Reverse Transcriptase and Implications for Drug Design, Jianping Ding, Kalyan Das, Prem N. S. Yadav, Yu Hsiou, Wanyi Zhang, Stephen H. Hughes, and Edward ArnoldRetroviral Integrase: Structure as a Foundation for Drug Design, Alison B. Hickman and Fred DydaArthritis and InflammationBradykinin Receptor Antagonists, Donald J. KyleCancerDesign of Purine Nucleoside Phosphorylase Inhibitors, Y. Sudhakara Babu, John A. Montgomery, Charles E. Bugg, W. Michael Carson, Sthanam V. L. Narayana, William J. Cook, Steven E. Ealick, Wayne C. Guida, Mark Erion, and John Secrist IIIStructural Implications in the Design of Matrix-Metalloproteinase Inhibitors, John C. SpurlinoStructure - Function Relationships in Hydroxysteroid Dehydrogenases, Igor Tsigelny and Michael BakerDesign of ATP Competitive Specific Inhibitors of Protein Kinases Using Template Modeling, Janusz M. Sowadski, Charles A. Ellis, Rolf Karlsson, and MadhusudanDiabetes MellitisStructural Studies of Aldose Reductase Inhibition, David K. Wilson, J. Mark Petrash, and Florante A. QuiochoHeart DiseasesStructure-Based Design of Thrombin Inhibitors, Patricia C. Weber and Michael CzarnieckiDesign of Antithrombotic Agents Directed at Factor Xa, William C. RipkaPolypeptide Modulators of Sodium Channel Function as a Basis for the Development of Novel Cardiac Stimulants, Raymond S. NortonRational Design of Renin Inhibitors, V. Dhanaraj and J. B. CooperParkinson's DiseaseStructural Aspects in the Inhibitor Design of Catechol O-Methyltransferase, Jukka Vidgren and Martti OvaskaSleeping SicknessAntitrypanosomiasis Drug Development Based on Structures of Glycolytic Enzymes, Christopher L. M. J. Verlinde, Hidong Kim, Bradley E. Bernstein, Shekhar C. Mande, and Wim G. J. HolImmune Diseases and CytokinesProgress in the Design of Immunomodulators Based on the Structure of Interleukin-1, Glen Spraggon and Pandi VeerapandianStructure and Functional Studies of Interferon: A Solid Foundation for Rational Drug Design, Michael A. Jarpe, Carol H. Pontzer, Brian E. Szente, and Howard M. JohnsonAntiviralsThe Design of Anti-Influenza Virus Drugs from the X-Ray Molecular Structure of Influenza Virus Neuraminidase, Joseph N. VargheseRhinoviral Capsid-Binding Inhibitors: Structural Basis for Understanding Rhinoviral Biology and for Drug Design, Vincent L. Giranda and Guy D. DianaNovel MethodologiesThe Integration of Structure-Based Design and Directed Combinatorial Chemistry for New Pharmaceutical Discovery, Roger Bone and F. Raymond SalemmeStructure-Based Combinatorial Ligand Design, Amedeo Caflisch and Claus EhrhardtPeptidomimetic and Neopeptide Drug Discovery: Impact on Structure-Based Drug Design, Tomi K. Sawyer