Diamond-Based Materials for Biomedical Applications

Dr. Roger Narayan is a Professor in the Joint Department of Biomedical Engineering at the University of North Carolina and North Carolina State University. He is an author of more than 100 publications as well as several book chapters on nanostructured biomedical materials. Dr. Narayan has received several honors for his research activities, including the NCSU Alcoa Foundation Engineering Research Achievement Award, the NCSU Sigma Xi Faculty Research Award, the University of North Carolina Jefferson-Pilot Fellowship in Academic Medicine, the University of North Carolina Junior Faculty Development Award, the National Science Faculty Early Career Development Award, the Office of Naval Research Young Investigator Award, and the American Ceramic Society Richard M. Fulrath Award. He has been elected as Fellow of the American Ceramic Society, the American Association for the Advancement of Science, the American Institute for Medical & Biological Engineering, and ASM International.

• Contributor contact detailsWoodhead Publishing Series in BiomaterialsPart I: Introduction to diamond-based materials for medical applicationsChapter 1: Introduction to medical applications of diamond particles and surfacesAbstract:1.1 Introduction1.2 Growth of synthetic diamond1.3 Diamond-based medical devices1.4 Functionalization of nanodiamond and nanocrystalline diamond1.5 Drug delivery using nanodiamond1.6 Imaging with nanodiamond1.7 Conclusion1.8 AcknowledgmentsChapter 2: Functionalization of diamond surfaces for medical applicationsAbstract:2.1 Introduction2.2 Electrochemical reduction of aryldiazonium salts2.3 Photochemical modification2.4 Preparation of amine-terminated diamond surfaces2.5 Preparation of oxygen-terminated diamond surfaces2.6 Conclusion and future trendsChapter 3: Biotribology and biological behaviour of nanocrystalline diamond (NCD) coatings for medical applicationsAbstract:3.1 Introduction to nanocrystalline diamond (NCD)3.2 NCD-coated silicon nitride ceramics as new materials for joint replacement3.3 Growth and characterization of NCD films deposited on Si3N4 substrates3.4 Biotribology of NCD coatings3.5 Biological behaviour of NCD-coated Si3N4 ceramicsChapter 4: Blood compatibility of diamond-like carbon (DLC) coatingsAbstract:4.1 Introduction4.2 Diamond-like carbon (DLC) structure, properties and applications4.3 Deposition techniques for DLC films4.4 DLC blood compatibility4.5 Modified DLC films4.6 Biomedical applications of DLC coatings4.7 Conclusion and future trendsPart II: Biomedical applications of diamond-based materialsChapter 5: Nanostructured diamond coatings for orthopaedic applicationsAbstract:5.1 Introduction5.2 Ultra-hard carbon coatings5.3 Wear measurements for ceramic-based orthopaedic implants5.4 Mesenchymal stem cells derived from bone marrow and their interactions with nanostructured diamond surfaces5.5 Macrophage cell interactions to diamond wear debris5.6 In vivo evaluation of nanostructured diamond surfaces5.7 Future trends5.8 AcknowledgementsChapter 6: Ultrananocrystalline diamond (UNCD) films for ophthalmological applicationsAbstract:6.1 Introduction6.2 The use of ultrananocrystalline diamond (UNCD) films as coatings in the restoration of sight in people blinded by degenerated photoreceptors6.3 The use of UNCD films in the treatment of glaucoma6.4 Integrated magnet/superparamagnetic nanoparticles interacting system for new treatment of retina detachment6.5 Conclusions6.6 AcknowledgmentsChapter 7: Ultrananocrystalline diamond (UNCD) for neural applicationsAbstract:7.1 Introduction7.2 Mechanism aspects of ultrananocrystalline diamond (UNCD)/neural cell interactions7.3 Methods of guiding neurons7.4 Neural and retinal prosthesesChapter 8: Nanodiamonds for drug delivery systemsAbstract:8.1 Introduction8.2 Surface modification of diamond nanoparticles for drug delivery and targeting8.3 Development of nanodiamond-based drug delivery for proteins8.4 Development of nanodiamond-based drug delivery for genes8.5 Development of nanodiamond-based drug delivery for low molecular weight therapeutic agents8.6 Biocompatibility, biodistribution and biological fate of nanodiamonds8.7 ConclusionsChapter 9: Diamond nucleation and seeding techniques for tissue regenerationAbstract:9.1 Introduction9.2 Diamond nucleation9.3 Methods for diamond nucleation and seeding9.4 Bias enhanced nucleation in hot filament chemical vapour deposition9.5 Ultrasonic seeding9.6 Seeding using a polymer composite9.7 Spontaneous nucleation9.8 Biological and tissue engineering applicationsChapter 10: Diamond materials for microfluidic devicesAbstract:10.1 Introduction10.2 Materials for the manufacture of microfluidic devices10.3 Diamond microfluidic devices10.4 Conclusions and future trends10.5 AcknowledgmentsIndex