Biomaterials for Cancer Therapeutics

Kinam Park is Showalter Distinguished Professor of Biomedical Engineering & Professor of Pharmaceutics at Purdue University, USA. His research focuses in the areas of nano/micro particles, polymer micelles, drug-eluting stents, extracellular matrix, fast dissolving tablets, and smart hydrogels.

"On the whole, the book is a combination of the fundamentals of cancer biology, guiding principles on the design of biomaterials and the clinical potential of these biomaterials, which is of interest to a broad audience involving chemists, biologist and material scientists." --Biomat.net, June 2014"Intended for researchers, this collection introduces new methods for delivering drugs to cancer cells and tumors and innovative technologies for treating cancers with biomaterials. Needham …describes his low temperature-sensitive liposome (Thermodox) drug delivery system, which failed to meet its primary endpoint in a phase III trial of liver cancer." --ProtoView.com, February 2014

• Contributor contact detailsWoodhead Publishing Series in BiomaterialsPrefaceChapter 1: Introduction to biomaterials for cancer therapeuticsAbstract:1.1 Introduction1.2 Biomaterials used in cancer therapeutics1.3 Materials used in anticancer formulations1.4 Conclusion and future trendsChapter 2: Cancer cell biologyAbstract:2.1 Introduction2.2 Public perception and misunderstanding of cancer cell activity2.3 The ‘War on Cancer’2.4 The genetic basis of cancer2.5 Cancer interface with the environment2.6 Cancer cells as moving targets2.7 Conclusion and future trendsChapter 3: Targeted drug delivery for cancer therapyAbstract:3.1 Introduction3.2 Current paradigm3.3 Challenges to current paradigm3.4 Conclusion and future trendsChapter 4: Chemical synthesis of carbohydrate-based vaccines against cancersAbstract:4.1 Introduction4.2 Semi-synthetic vaccines4.3 Fully synthetic vaccines4.4 Conclusion and future trendsChapter 5: Generating functional mutant proteins to create highly bioactive anticancer biopharmaceuticalsAbstract:5.1 Introduction5.2 Artificial proteins for cancer therapy5.3 How to create functional mutant proteins as beneficial therapeutics5.4 Mutant TNFα for cancer therapy5.5 Conclusion and future trends5.6 Sources of further information and adviceChapter 6: Polymer therapeutics for treating cancerAbstract:6.1 Introduction6.2 Polyamines and polyamine analogs6.3 Polymeric P-glycoprotein (Pgp) inhibitors6.4 Conclusion and future trends6.5 AcknowledgmentChapter 7: Nanotechnology for cancer screening and diagnosisAbstract:7.1 Introduction7.2 Nanotechnology for cancer diagnosis7.3 Nanotechnology-based biosensing platforms7.4 Nanotechnology for biosensing – early detection of cancer7.5 Nanotechnology for cancer imaging7.6 Concerns with using nanomaterials7.7 Conclusion and future trendsChapter 8: Synergistically integrated nanomaterials for multimodal cancer cell imagingAbstract:8.1 Introduction8.2 Nanomaterial-based multifunctional imaging probes8.3 Nanoparticles with exogenous imaging ligands8.4 Nanoparticles with endogenous contrast8.5 Cocktail injection8.6 ConclusionChapter 9: Hybrid nanocrystal as a versatile platform for cancer theranosticsAbstract:9.1 Introduction9.2 Imaging modality9.3 Developing theranostic systems9.4 Hybrid nanocrystal as theranostic platform9.5 Conclusion9.6 AcknowledgmentChapter 10: Embolisation devices from biomedical polymers for intra-arterial occlusion drug delivery in the treatment of cancerAbstract:10.1 Introduction10.2 Biomedical polymers and embolisation agents10.3 Particulate embolisation agents10.4 Drug-eluting embolisation beads10.5 Polymer structure, form and property relationships10.6 Experience with drug-eluting embolisation beads10.7 Conclusions and future trends10.8 AcknowledgementChapter 11: Small interfering RNAs (siRNAs) as cancer therapeuticsAbstract:11.1 Introduction11.2 Prerequisites for siRNAs cancer therapeutics11.3 Delivery systems for anticancer siRNAs11.4 Current challenges for clinical trials11.5 Conclusion11.6 AcknowledgementChapter 12: Reverse engineering of the low temperature-sensitive liposome (LTSL) for treating cancerAbstract:12.1 Introduction12.2 What is reverse engineering?12.3 Investigating the thermal-sensitive liposome’s performance-in-service12.4 Defining the function of the liposome12.5 Component design: mechanism of action12.6 Selecting the most appropriate material when designing the Dox-LTSL12.7 Analysis of materials performance in the design12.8 Specification sheet12.9 Production12.10 Prototypes12.11 Further development12.12 Conclusion and future trends12.13 AcknowledgementsChapter 13: Gold nanoparticles (GNPs) as multifunctional materials for cancer treatmentAbstract:13.1 Introduction13.2 Physical properties of gold nanoparticles13.3 Surface chemistry of GNPs13.4 GNPs as vehicles for drug delivery13.5 GNPs in biomedical imaging and theranostics13.6 GNPs as radiosensitizing agents13.7 Challenges in the development of GNPs as therapeutic agents13.8 Conclusion and future trends13.9 AcknowledgmentsChapter 14: Multifunctional nanosystems for cancer therapyAbstract14.1 Introduction14.2 Design of multifunctional nanosystems14.3 Illustrative examples of multifunctional nanosystems for tumor-targeted therapies14.4 Polymeric nanosystems14.5 Lipid nanosystems14.6 Hybrid nanosystems14.7 Regulatory and clinical perspectives14.8 ConclusionsChapter 15: Biomaterial strategies to modulate cancerAbstract:15.1 Introduction15.2 Understanding cancer with biomaterials15.3 Molecular markers for cancer15.4 Biomaterials for cancer therapy15.5 ConclusionChapter 16: 3D cancer tumor models for evaluating chemotherapeutic efficacyAbstract:16.1 Introduction16.2 Efforts to fight cancer16.3 Preclinical drug evaluation in cellular and animal models16.4 In vivo environment16.5 2D vs 3D culture systems16.6 3D tumor models16.7 Methods to culture multicellular tumor spheroids16.8 ConclusionChapter 17: Nanotopography of biomaterials for controlling cancer cell functionAbstract:17.1 Introduction17.2 The influence of surface topography and roughness of PLGA on cancer cells: creation of nanoscale PLGA surfaces17.3 The influence of nanoscale PLGA topographies on surface wettability and surface free energy17.4 The influence of PLGA nanotopographies on protein adsorption17.5 The impact of PLGA surface nanopatterns on cancer cell functions17.6 The impact of nanopatterns and LBL monolayers on cell functions17.7 ConclusionsIndex