"This book will be very useful to both new investigators in the field and persons who have a general interest in rotaviruses and the methods to be used in their study. Many chapter contributors also provide very useful summaries of the methods used in a specific aspect of rotavirus research. These will be helpful to even the most experienced investigator in the field. "-Doody's Health Sciences Book Review Journal "This book has no recent equivalent...The book will not only be profitable for the RV specialist; people interested in other viruses or cellular physiology will surely benefit from the lessons learned from studies of RV electron cryomicroscopy, RV replication or animal models of RV infections." - Trends in Microbiology "...methods, which have proven invaluable to studies, are given in detail in this excellent new book. The contributors have written detailed protocols for, predominantly, molecular and serological methods with emphases on those that are somewhat unique to rotavirus research...However, there is much more to this book than the highly detailed protocols...The last of the central chapters is by Mary Ramsay and David Brown and describes the epidemiology of rotavirus infections and concentrates on surveillance and disease burden. Anyone still unconvinced of the need for a rotavirus vaccine should read this chapter."-J. Med. Microbiol "This high quality compendium comprises 12 concise chapters, each presented in the same easy to follow layout...this book at $89.50 is reasonable value and an essential reference for any laboratory undertaking rotavirus research."- Microbiology Today

• Rotaviruses: Basic Facts.- Electron Cryomicroscopy and Computer Image Processing Techniques.- Virus Replication.- Rotavirus Entry into Tissue Culture Cells.- Mixed Infections with Rotaviruses.- Pathogenesis and Animal Models.- Immunologic Methods and Correlates of Protection.- In Vivo Study of Immunity to Rotaviruses.- Evaluation of Rotavirus Vaccines in Small Animal Models.- Methods of Rotavirus Detection, Sero- and Genotyping, Sequencing, and Phylogenetic Analysis.- Epidemiology of Group A Rotaviruses Surveillance and Burden of Disease Studies.- Future Rotavirus Research.